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Protein Overview: SLM1

General Information:
Name(s) found: SLM1 / YIL105C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: TORC2 complex [IPILink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of cell growth [IGILink to PubMed article][IPILink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IPILink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: phosphoinositide binding [IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNNTMTSA VSDMLSQQQL NLQHLHNLQQ HTRSMTSADH ANVLQQQQQQ QQQQQQQQQQ  60
   61 QQQSASFQNG SLTSDINQQS YLNGQPVPST SNSTFQNNRT LTMNSGGLQG IISNGSPNID 120
  121 SNTNVTIAVP DPNNNNGKQL QGKNSLTNTS ILSRARSSLQ RQRLAQQQQQ QQDPRSPLVI 180
  181 LVPTAAQPTD ILAARFSAWR NVIKSVIVYL TEIASIQDEI VRQQLRLSHA VQFPFFSIEN 240
  241 QYQPSSQEDK SVQKFFLPLG NGSIQDLPTI LNQYHESLAS SASKASRELT NDVIPRLEDL 300
  301 RRDLIVKIKE IKSLQSDFKN SCSKELQQTK QAMKQFQESL KDARYSVPKQ DPFLTKLALD 360
  361 RQIKKQLQEE NFLHEAFDNL ETSGAELEKI VVMEIQNSLT IYARLLGQEA QLVFDILISK 420
  421 LDSGFFNVDP QFEWDNFISR DPNFLLPNLP MRTFKEIVYK YQFDPLTYEI KSGFLERRSK 480
  481 FLKSYSKGYY VLTPNFLHEF KTADRKKDLV PVMSLALSEC TVTEHSRKNS TSSPNSTGSD 540
  541 AKFVLHAKQN GIIRRGHNWV FKADSYESMM SWFDNLKILT STSNIQDKYK FITQKLNLNS 600
  601 DGKPKLTNNH TSINKYQLSN ANSTMVENDE NDDINSNYVG STVTPKLDNQ TNTNTSMSSL 660
  661 PDTNDSELQD QVPNIYIQTP INDFKS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABP1 BSP1 CRN1 INP52 LSP1 NOP53 RVS161 SLM1
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Ho Y, et al. (2002) MCK1 PNT1 SLM1 TRM3
    View Details Qiu et al. (2008) AVO2 BIT61 LST8 SLM1 SLM2 TOR2 TSC11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..254] ab initio 8.56 No description for 1itwA was found.
    3 View Details [255..409] ab initio 8.56 No description for 1itwA was found.
    4 View Details [410..467] ab initio 8.59 No description for 1i5pA was found.
    5 View Details [468..592] PSI-BLAST 30.39794 Grp1
    6 View Details [593..686] MSA 1.253996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle