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Protein Overview: SLM2

General Information:
Name(s) found: SLM2 / YNL047C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 656 amino acids

    Gene Ontology:
    Cellular Component: TORC2 complex [IPILink to PubMed article]
    plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of cell growth [IGILink to PubMed article][IPILink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IPILink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: phosphoinositide binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYQRNSARA SLDLRSQYQQ LEGRMRSEHF NPAYQQQQQK GQNIPLSLPS SLAQRNPIPY  60
   61 PIDAVTSDPT IPAQLNVYDH DRQNSIVDAA AGTNTTHSLN SNNIPSSQNN NINNNNINNV 120
  121 GSFTDPSMLT LPKMSLHSHQ KQYDSNQNDP RSPLAILIPT SAQPTDVLSA RFSAWRNVIR 180
  181 AILVYLSETA SIQDEIVRQQ LRLSHAVQFP FFSIENQYQP VSNEDKSMQK FFLPLGSGSV 240
  241 QDLPTMLTKY HDNLASLASK SSKELTSEII PRLEDLRRDL LVKIKEIKAL QSDFKNSCNK 300
  301 ELQQTKHLMK LFNESLKECK LGTPKSDPFL IKLQLEKQIK RQLVEENYLH EAFDNLQNSG 360
  361 AQLESVIVME IQNGLTSYAR ILGKEAQVVF DSVISKLDST ILNKNTNLEW DSFILRNISN 420
  421 FVPPNLPMRR FKEISYSNQN DPFTFEVKSG FLEKRSKFLK SYSRGFYVLT PSFLHEFKTP 480
  481 DKHKFSTPLM SIPLVECTVT EHSKKTKSNS EQGKNKFILR TNSNGLIHRG HNWVFKVDSY 540
  541 DDMIEWFGNI KALSSLPNYD DKCKYVSKVA KLSKEKAKSN ENTTESVTPQ VTNEQHTRYD 600
  601 DVSSSNFPLN SIPKLDNLTI TNTTSSIPET NDSQIQNRVP EFYIENVDSP RKSNQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) FAS1 FAS2 SLM2
    View Details Qiu et al. (2008) AVO2 LST8 SLM1 SLM2 TOR2 TSC11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] deduced N/A No confident structure predictions are available.
    2 View Details [122..289] ab initio 8.2 No description for 1i84S was found.
    3 View Details [290..404] ab initio 8.2 No description for 1i84S was found.
    4 View Details [405..595] PSI-BLAST 48.594777 Grp1
    5 View Details [596..656] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle