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View Structure Prediction Details

Protein: SAC6
Organism: Saccharomyces cerevisiae
Length: 642 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAC6.

Description E-value Query
Range
Subject
Range
SAC6 - Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and...
FIMB_YEAST - Fimbrin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAC6 PE=1 SV=1
0.0 [1..642] [1..642]
PLS3 - plastin 3
0.0 [11..638] [4..620]
PLST_MOUSE - Plastin-3 OS=Mus musculus GN=Pls3 PE=1 SV=3
0.0 [11..638] [7..623]
PLST_CRIGR - Plastin-3 OS=Cricetulus griseus GN=PLS3 PE=2 SV=2
0.0 [11..638] [4..620]
PLST_RAT - Plastin-3 OS=Rattus norvegicus GN=Pls3 PE=2 SV=1
0.0 [11..638] [4..620]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIVKLQRKF PILTQEDLFS TIEKFRAIDL DDKGWVEKQQ ALEAVSKDGD ATYDEARETL  60
   61 KHVGVDASGR VELDDYVGLV AKLRESKTGA APQTTFNVAP NSTPIVSTAA TGLQHKGKGT 120
  121 Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.045757
Match: 1a29__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.96919556235483 bayes_pls_golite062009
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
structural constituent of muscle 3.12414907235012 bayes_pls_golite062009
microfilament motor activity 2.9702957313812 bayes_pls_golite062009
binding 2.74623080162785 bayes_pls_golite062009
motor activity 2.57627414053278 bayes_pls_golite062009
actin filament binding 2.35534489389161 bayes_pls_golite062009
myosin binding 2.34125070430971 bayes_pls_golite062009
actin-dependent ATPase activity 2.06646671333275 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
ion binding 1.36376383271837 bayes_pls_golite062009
metal ion binding 1.34827363853601 bayes_pls_golite062009
cation binding 1.34827363853601 bayes_pls_golite062009
protein binding 1.16246005294206 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
actin monomer binding 0.9954841049256 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
transcription regulator activity 0.841197898920128 bayes_pls_golite062009
structural molecule activity 0.800850121197479 bayes_pls_golite062009
S100 beta binding 0.761814775111873 bayes_pls_golite062009
tubulin binding 0.710693016758742 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
myosin heavy chain binding 0.61866037435065 bayes_pls_golite062009
nucleic acid binding 0.582813108431922 bayes_pls_golite062009
DNA binding 0.50926539916695 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
myosin II binding 0.311147527050891 bayes_pls_golite062009
microtubule binding 0.278596514315141 bayes_pls_golite062009
molecular transducer activity 0.267701820661496 bayes_pls_golite062009
signal transducer activity 0.267701820661496 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
transcription repressor activity 0.168674124705245 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [122-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKIIVAGSQT GTTHTINEEE RREFTKHINS VLAGDQDIGD LLPFPTDTFQ LFDECRDGLV  60
   61 LSKLINDSVP DTIDTRVLNW PKKGKELNNF QASENANIVI NSAKAIGCVV VNVHSEDIIE 120
  121 GREHLILGLI WQIIRRGLLS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 693.450636
Match: 1aoa__
Description: N-terminal actin-crosslinking domain from fimbrin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.50245214720686 bayes_pls_golite062009
cytoskeletal protein binding 6.48140000563569 bayes_pls_golite062009
actin filament binding 5.47084878097979 bayes_pls_golite062009
tubulin binding 4.22039137964246 bayes_pls_golite062009
microtubule binding 4.15537672860167 bayes_pls_golite062009
binding 2.8655705697659 bayes_pls_golite062009
structural constituent of cytoskeleton 2.57886434162184 bayes_pls_golite062009
protein binding 2.36488136094907 bayes_pls_golite062009
microtubule plus-end binding 2.0465241878708 bayes_pls_golite062009
structural constituent of muscle 1.32485442580942 bayes_pls_golite062009
structural molecule activity 1.00964022808548 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [262-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIDIKLHPEL YRLLEDDETL EQFLRLPPEQ ILLRWFNYHL KQANWNRRVT NFSKDVSDGE  60
   61 NYTILLNQLD PALCSKAPLQ TTDLMERAEQ VLQNAEKLDC RKYLTPSSLV AGNPKLNLAF 120
  121 VAHLFNTHPG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 693.450636
Match: 1aoa__
Description: N-terminal actin-crosslinking domain from fimbrin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [392-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEPIQEEEKP EIEEFDAEGE REARVFTLWL NSLDVDPPVI SLFDDLKDGL ILLQAYEKVM  60
   61 PGAVDFKHVN KRPASGAEIS RFKALENTNY AVDLGRAKGF SLVGIEGSDI VDGNKLLTLG 120
  121 LVWQLMRRNI SITMKTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1g8xA_
Description: Genetically engineered molecular motor
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [529-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGRDMSDS QILKWAQDQV TKGGKNSTIR SFKDQALSNA HFLLDVLNGI APGYVDYDLV  60
   61 TPGNTEEERY ANARLAISIA RKLGALIWLV PEDINEVRAR LIITFIASLM TLNK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.99
Match: 1bkrA
Description: beta-spectrin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle