Protein Overview: FAP7

General Information:
Name(s) found:	FAP7 / YDL166C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6831740\|sp\|Q12055.1\|KAD6_YEAST RecName: Full=Putative adenylate kinase FAP7; AltName: Full=ATP-AMP transphosphorylase FAP7; AltName: Full=POS9-activating factor 7 [NCBI NR] gi\|6320035\|ref\|NP_010115.1\| Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for si [NCBI NR] pir\|\|S61047 hypothetical protein YDL166c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1431264\|emb\|CAA98740.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1061273\|emb\|CAA91580.1\| putative protein [Saccharomyces cerevisiae] [NCBI NR] Putative adenylate kinase FAP7 OS=Saccharomyces cerevisiae GN=FAP7 PE=1 SV=1 [Swiss-Prot] POS9-activating factor FAP7 OS=Saccharomyces cerevisiae GN=FAP7 PE=1 SV=1 [Swiss-Prot] FAP7 Protein involved in the oxidative stress response [mips] Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D [SGD] YDL166C, Chr IV from 163450-164043, reverse complement [yeast_orfs2] Chr IV from 163450-164043, reverse complement [yeastorf3.fasta] Chr IV from 164043-163450, reverse complement [yeastorf5.fasta] (Q12055) Hypothetical 22.7 kDa protein in CDC36-NRP1 intergenic region [4932.FASTACCERV.txt] FAP7 SGDID:S0002325, Chr IV from 164043-163450, reverse complement, Verified ORF [yeastflysequest.fasta] Essential nuclear protein, involved in the oxidative stress response [Saccharomyces cerevisiae]gi\|1431264\|emb\|CAA98740.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1061273\|emb\|CAA91580.1\| putative protein [Saccharomyces cerevisiae]gi\|6831740 [nrdb_11152004_Chlamydomonas] (Q12055) POS9-activating factor FAP7 [cerv4932.FASTAC] FAP7 SGDID:S000002325, Chr IV from 164043-163450, reverse complement, Verified ORF, "Essential nuclear protein, involved in the oxidative stress response" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] FAP7 SGDID:S000002325, Chr IV from 164043-163450, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43 [yeast-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; Fap7p [Saccharomyces c [nr-271106-contam.fasta] putative protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] POS9-activating factor FAP7 [nr-271106-contam.fasta] FAP7 SGDID:S000002325, Chr IV from 164043-163450, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Putative adenylate kinase FAP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAP7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] FAP7 SGDID:S000002325, Chr IV from 164042-163449, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D" [yeast-030211-contam.fasta] Adenylate kinase isoenzyme 6 homolog FAP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAP7 PE=1 SV=1 [YEAST.fasta.20131015] FAP7 SGDID:S000002325, Chr IV from 164042-163449, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes" [20141208_orf_trans.fasta] YDL166C SGDID:S000002325, Chr IV from 164042-163449, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	197 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IMP] [NOT]preribosome [IPI]
Biological Process:	[NOT]ribosomal small subunit export from nucleus [IMP] response to oxidative stress [IMP] maturation of SSU-rRNA [IMP ][IPI]
Molecular Function:	nucleoside-triphosphatase activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEARRYGPNI IVTGTPGCGK SSTCEFLKNK LKDYKYYNIS DFAKDNDCFE GYDEGRKSHI  60
   61 VDEDKLLDML EPLLRQGNSI VDWHVNDVFP ERLIDLVVVL RCDNSNLYSR LHARGYHDSK 120
  121 IEENLDAEIM GVVKQDAVES YEPHIVVELQ SDTKEDMVSN VSRIVAWEKM WLEQHPDGVT 180
  181 NEYQGPRSDD EDDEDSE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 GCN1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP14 NOP56 NOP58 NOP6 PNO1 PRE6 PRE9 PRP43 PWP2 RCL1 RML2 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RPS14A	FAP7	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	FAP7	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..197]	PSI-BLAST	28.0	Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.47805400577115	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.46449952222453	bayes_pls_golite062009
histone acetyltransferase activity	5.46449952222453	bayes_pls_golite062009
N-acetyltransferase activity	4.25864282850521	bayes_pls_golite062009
N-acyltransferase activity	4.00838185080866	bayes_pls_golite062009
acetyltransferase activity	3.73766943057668	bayes_pls_golite062009
acyltransferase activity	3.24721386513202	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.21286388740986	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.04795936672801	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.09956015274464	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
DNA binding	1.87765278833074	bayes_pls_golite062009
RNA helicase activity	1.42791449104435	bayes_pls_golite062009
RNA-dependent ATPase activity	1.39335733374328	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.36724390116598	bayes_pls_golite062009
purine ribonucleotide binding	1.2935968641033	bayes_pls_golite062009
ribonucleotide binding	1.2935353851804	bayes_pls_golite062009
purine nucleotide binding	1.29138695385133	bayes_pls_golite062009
nucleotide binding	1.28669586915546	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
transcription elongation regulator activity	1.11383295816593	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
transcription factor activity	0.682439846757997	bayes_pls_golite062009
motor activity	0.677658554107	bayes_pls_golite062009
helicase activity	0.6191010101321	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
	0.442119153778711	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.29664013896754	bayes_pls_golite062009
ATP-dependent helicase activity	0.29664013896754	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
nucleotidyltransferase activity	0.181509771587324	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
pyrophosphatase activity	0.133017653323467	bayes_pls_golite062009
microtubule motor activity	0.11674780318211	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009
RNA binding	0.0261282189186349	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2