Protein Overview: TEL1

General Information:
Name(s) found:	TEL1 / YBL088C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319383\|ref\|NP_009465.1\| Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene; Tel1 [NCBI NR] gi\|1870083\|emb\|CAA84909.1\| TEL1 [Saccharomyces cerevisiae] [NCBI NR] gi\|114152775\|sp\|P38110.2\|ATM_YEAST RecName: Full=Serine/threonine-protein kinase TEL1; AltName: Full=DNA-damage checkpoint kinase TEL1; AltName: Full=Telomere length regulation protein 1; AltName: Full=ATM homolog [NCBI NR] Serine/threonine-protein kinase TEL1 OS=Saccharomyces cerevisiae GN=TEL1 PE=1 SV=2 [Swiss-Prot] TEL1 Telomere length control protein [mips] Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene [SGD] TEL1, Chr II from 51013-59376, reverse complement [yeast_orfs2] Chr II from 51013-59376, reverse complement [yeastorf3.fasta] Chr II from 59376-51013, reverse complement [yeastorf5.fasta] TEL1 SGDID:S0000184, Chr II from 59379-51016, reverse complement, Verified ORF [yeastflysequest.fasta] Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene [Saccharomyces cerevisiae]gi\|18 [nrdb_11152004_Chlamydomonas] TEL1 SGDID:S000000184, Chr II from 59379-51016, reverse complement, Verified ORF, "Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TEL1 SGDID:S000000184, Chr II from 59379-51016, reverse complement, Verified ORF, "Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; [yeast-contam.fasta] Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene; Tel1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TEL1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Serine/threonine-protein kinase TEL1 (DNA-damage checkpoint kinase TEL1) (Telomere length regulation protein 1) (ATM homolog) [nr-271106-contam.fasta] TEL1 SGDID:S000000184, Chr II from 59379-51016, reverse complement, Verified ORF, "Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene" [yeast-bovrabprots.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	2787 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC ][TAS] mitochondrion [IDA ]
Biological Process:	DNA double-strand break processing [IGI][IMP] telomere maintenance [IMP] telomere maintenance via telomerase [IMP] phosphorylation [IMP] response to DNA damage stimulus [IMP]
Molecular Function:	protein kinase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA LVELLASEHT  60
   61 KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE RFKVKTLKLL LAVVPELMVK 120
  121 DGSKSLLDAV SVHLSFALDA LIKSDPFKLK FMIHQWISLV DKICEYFQSQ MKLSMVDKTL 180
  181 TNFISILLNL LALDTVGIFQ VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF 240
  241 SVIDTLMLIK EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR 300
  301 SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR LRDRGGRSVW 360
  361 LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL RISDDMDTFL IHLLEENSSH 420
  421 EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL LFSKFEKIQC FNWVCFSFIP LLSQKECELS 480
  481 NGDMARLFKV CLPLVKSNES CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP 540
  541 ILVTNESFML WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW 600
  601 LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE KSECFNTPFF 660
  661 NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK LIQIVDNLCG DSTFSEFIAA 720
  721 YKRTTLITIP QLSFDSQNSY QSFFEEVLSI RTINVDHLVL DKINMKEIVN DFIRMQKNKS 780
  781 QTGTSAINYF EASSEDTTQN NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA 840
  841 ILEFSDCVST DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA 900
  901 MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV NLSMLLLSLL 960
  961 QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI SSYMAQVSYK NQSIIFYEIK1020
 1021 SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS LVFSLEDMMT YSGFNHTRAF IQQALNKITV1080
 1081 AFRYQNLTEL FEYCKFDLIM YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA1140
 1141 IYFSQGFNQK WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT1200
 1201 TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS VSMRYQYPLH1260
 1261 IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST YIGKLRCARE LKYLFVLYEN1320
 1321 VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY1380
 1381 LRENKQLSPS FQQAIKLLEH RDLIKIKTWK YFLDAIFGNI VQDDIYENTE LLDASDCGVD1440
 1441 DVVLVSLLFS YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ1500
 1501 EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE VFFISECILT1560
 1561 YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY PLANNFGMES FICDTYLSVN1620
 1621 EPYNCWLSKF ARSLIHQISF NIPPIVCLYP LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN1680
 1681 WSNRIFTQIA MLLHVKDSEI KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL1740
 1741 KIKEFKFGYL LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI1800
 1801 DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL SGSSDVYKWN1860
 1861 LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE KSLLTIFDSR QHFISQTEWM1920
 1921 DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM KADKERLNTI DFYDHKTTLK SRHTLMNVLS1980
 1981 RNSLDENVKC SKYLRLGSII QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS2040
 2041 VVSQIEKLAS FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ2100
 2101 IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD EQAQKLRSNG2160
 2161 EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY NRVLLQYNRD SEVLKALLLQ2220
 2221 KEKFLWHALH FYLNTLVFSN RYDNDIIDKF CGLWFENDDN SKINQLLYKE IGTIPSWKFL2280
 2281 PWVNQIASKI SMEENEFQKP LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI2340
 2341 QAVKKILLEL QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL2400
 2401 KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV TFNISDGTTQ2460
 2461 KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG IRTYKVVPLG PKAGIIEFVA2520
 2521 NSTSLHQILS KLHTNDKITF DQARKGMKAV QTKSNEERLK AYLKITNEIK PQLRNFFFDS2580
 2581 FPDPLDWFEA KKTYTKGVAA SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK2640
 2641 LLPIPELVPF RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY2700
 2701 SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE KLMGNGLSVE2760
 2761 SSVQDLIQQA TDPSNLSVIY MGWSPFY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		BDF2 CDC55 CKB1 DYN1 ECM5 FUN30 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
View Details	Ho Y, et al. (2002)		GDE1 TEL1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	KIP3	No Comments	Cheeseman IM, et al. (2002)
View Run	RBA50	No Comments	Hazbun TR, et al. (2003)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TEL1	RUD3	2	Unpublished Fields Lab Data
View Screen	TEL1	YJL114W	2	Unpublished Fields Lab Data
View Screen	TEL1	PET494	2	Unpublished Fields Lab Data
View Screen	TEL1	PET494	2	Unpublished Fields Lab Data
View Screen	TEL1	TRP1	1	Unpublished Fields Lab Data
View Screen	TEL1	ARG81	1	Unpublished Fields Lab Data
View Screen	TEL1	PHM6	1	Unpublished Fields Lab Data
View Screen	TEL1	ATP25	1	Unpublished Fields Lab Data
View Screen	TEL1	EAF1	1	Unpublished Fields Lab Data
View Screen	TEL1	SWP1	1	Unpublished Fields Lab Data
View Screen	TEL1	YER084W	1	Unpublished Fields Lab Data
View Screen	TEL1	SPS18	1	Unpublished Fields Lab Data
View Screen	TEL1	TUB2	1	Unpublished Fields Lab Data
View Screen	TEL1	YIF1	1	Unpublished Fields Lab Data
View Screen	TEL1	NPY1	1	Unpublished Fields Lab Data
View Screen	TEL1	LCB4	1	Unpublished Fields Lab Data
View Screen	TEL1	AYR1	1	Unpublished Fields Lab Data
View Screen	TEL1	ASG1	1	Unpublished Fields Lab Data
View Screen	TEL1	MPD1	1	Unpublished Fields Lab Data
View Screen	TEL1	NUP82	1	Unpublished Fields Lab Data
View Screen	TEL1	FRT1	1	Unpublished Fields Lab Data
View Screen	TEL1	ICS3	1	Unpublished Fields Lab Data
View Screen	TEL1	SPO19	1	Unpublished Fields Lab Data
View Screen	TEL1	YDR262W	1	Unpublished Fields Lab Data
View Screen	TEL1	AIR1	1	Unpublished Fields Lab Data
View Screen	TEL1	URA3	1	Unpublished Fields Lab Data
View Screen	TEL1	YJR011C	1	Unpublished Fields Lab Data
View Screen	TEL1	YIL092W	1	Unpublished Fields Lab Data
View Screen	TEL1	BFA1	1	Unpublished Fields Lab Data
View Screen	TEL1	MMS4	1	Unpublished Fields Lab Data
View Screen	TEL1	TPK3	1	Unpublished Fields Lab Data
View Screen	RAD51	TEL1	1	Unpublished Fields Lab Data
View Screen	TEL1	ROT2	1	Unpublished Fields Lab Data
View Screen	TEL1	MRPL20	1	Unpublished Fields Lab Data
View Screen	RAD6	TEL1	1	Unpublished Fields Lab Data
View Screen	TEL1	CDC10	1	Unpublished Fields Lab Data
View Screen	TEL1	YML6	1	Unpublished Fields Lab Data
View Screen	NUP2	TEL1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..1325]	MSA	1.002001	View MSA. No confident structure predictions are available.
2	View Details	[1326..1719]	deduced	N/A	No confident structure predictions are available.
3	View Details	[1720..2102]	Pfam	12.537602	FAT domain No confident structure predictions are available.
4	View Details	[2103..2754]	PSI-BLAST	167.980454	Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
5	View Details	[2755..2787]	Pfam	15.920819	FATC domain No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
protein kinase activity	5.4586557943719	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.04467222534257	bayes_pls_golite062009
kinase activity	4.85903980916957	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.63692708178478	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.26787750561728	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
calcium-dependent phospholipid binding	1.06635493706319	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.684204466593894	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
nucleic acid binding	0.444972929276369	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
clathrin binding	0.35775052108553	bayes_pls_golite062009
neurexin binding	0.27749877320051	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
transcription regulator activity	0.222474717779546	bayes_pls_golite062009
DNA binding	0.198054762876122	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.196560862858137	bayes_pls_golite062009
SNARE binding	0.102282725391911	bayes_pls_golite062009
nuclear localization sequence binding	0.0935103343162811	bayes_pls_golite062009
transcription factor activity	0.026050048647416	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.75

Source: Reynolds et al. (2008)

TMHMM	pre 2.0c	PSIPRED	pre v2.61
SignalP	pre 3.0	COILS	1999
DISOPRED	pre v0.2	NCBI nr	circa 2005
PSI-BLAST	~2.2.10	FFAS	ffas
PDB	~2005	Pfam	16
HMMER	2.3.1