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Protein Overview: MPD1

General Information:
Name(s) found: MPD1 / YOR288C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 318 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: protein folding [IGILink to PubMed article]
    Molecular Function: protein disulfide isomerase activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    protein disulfide oxidoreductase activity [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFLNIIKLL LGLFIMNEVK AQNFYDSDPH ISELTPKSFD KAIHNTNYTS LVEFYAPWCG  60
   61 HCKKLSSTFR KAAKRLDGVV QVAAVNCDLN KNKALCAKYD VNGFPTLMVF RPPKIDLSKP 120
  121 IDNAKKSFSA HANEVYSGAR TLAPIVDFSL SRIRSYVKKF VRIDTLGSLL RKSPKLSVVL 180
  181 FSKQDKISPV YKSIALDWLG KFDFYSISNK KLKQLTDMNP TYEKTPEIFK YLQKVIPEQR 240
  241 QSDKSKLVVF DADKDKFWEY EGNSINKNDI SKFLRDTFSI TPNEGPFSRR SEYIAYLKTG 300
  301 KKPIKKNHSS SGNKHDEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CHL4 No Comments Cheeseman IM, et al. (2002)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MPD1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] PSI-BLAST 129.154902 Protein disulfide isomerase, PDI
    2 View Details [157..318] PSI-BLAST 12.154902 Protein disulfide isomerase, PDI


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle