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Protein Overview: SSA1

General Information:
Name(s) found: SSA1 / YAL005C [SGD]
Description(s) found:
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  • gi|6319314|ref|NP_009396.1| ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and [NCBI NR]
  • gi|349747|gb|AAC04952.1| Ssa1p: Heat shock protein of HSP70 family [Saccharomyces cerevisiae] [NCBI NR]
  • pir||HHBYA1 dnaK-type molecular chaperone SSA1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • SSA1 Heat shock protein of HSP70 family, cytosolic [mips]
  • ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall [SGD]
  • SSA1, Chr I from 139501-141429, reverse complement [yeast_orfs2]
  • Chr I from 139501-141429, reverse complement [yeastorf3.fasta]
  • Chr I from 139505-141433, reverse complement [yeastorf4.fasta]
  • Chr I from 141433-139505, reverse complement [yeastorf5.fasta]
  • SSA1 SGDID:S0000004, Chr I from 141435-139507, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SSA1 SGDID:S0000004, Chr I from 141433-139505, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Ssa1p [Saccharomyces cerevisiae]gi|319952|pir||HHBYA1 dnaK-type molecular chaperone SSA1 - yeast (Saccharomyces cerevisiae)gi|349747|gb|AAC04952.1| Ssa1p: Heat shock protein of HSP70 family [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • SSA1 SGDID:S000000004, Chr I from 141433-139505, reverse complement, Verified ORF, "ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone comp [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ssa1p: Heat shock protein of HSP70 family [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall; Ssa1p [Saccharom [nr-271106-contam.fasta]
  • SSA1 SGDID:S000000004, Chr I from 141433-139505, reverse complement, Verified ORF, "ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall" [yeast-contam_custom.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    chaperonin-containing T-complex [IPILink to PubMed article]
    fungal-type cell wall [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: protein targeting to mitochondrion [IMPLink to PubMed article]
    SRP-dependent cotranslational protein targeting to membrane, translocation [IDALink to PubMed article]
    protein import into nucleus, translocation [IDALink to PubMed article]
    protein folding [IDALink to PubMed article]
    protein refolding [IDALink to PubMed article]
    response to stress [IMPLink to PubMed article]
    translation [IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    unfolded protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAVGIDLG TTYSCVAHFA NDRVDIIAND QGNRTTPSFV AFTDTERLIG DAAKNQAAMN  60
   61 PSNTVFDAKR LIGRNFNDPE VQADMKHFPF KLIDVDGKPQ IQVEFKGETK NFTPEQISSM 120
  121 VLGKMKETAE SYLGAKVNDA VVTVPAYFND SQRQATKDAG TIAGLNVLRI INEPTAAAIA 180
  181 YGLDKKGKEE HVLIFDLGGG TFDVSLLFIE DGIFEVKATA GDTHLGGEDF DNRLVNHFIQ 240
  241 EFKRKNKKDL STNQRALRRL RTACERAKRT LSSSAQTSVE IDSLFEGIDF YTSITRARFE 300
  301 ELCADLFRST LDPVEKVLRD AKLDKSQVDE IVLVGGSTRI PKVQKLVTDY FNGKEPNRSI 360
  361 NPDEAVAYGA AVQAAILTGD ESSKTQDLLL LDVAPLSLGI ETAGGVMTKL IPRNSTISTK 420
  421 KFEIFSTYAD NQPGVLIQVF EGERAKTKDN NLLGKFELSG IPPAPRGVPQ IEVTFDVDSN 480
  481 GILNVSAVEK GTGKSNKITI TNDKGRLSKE DIEKMVAEAE KFKEEDEKES QRIASKNQLE 540
  541 SIAYSLKNTI SEAGDKLEQA DKDTVTKKAE ETISWLDSNT TASKEEFDDK LKELQDIANP 600
  601 IMSKLYQAGG APGGAAGGAP GGFPGGAPPA PEAEGPTVEE VD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIM1 No Comments Cheeseman IM, et al. (2002)
    View Run CHL4 No Comments Cheeseman IM, et al. (2002)
    View Run MCM16 No Comments Cheeseman IM, et al. (2002)
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run STU1 No Comments Cheeseman IM, et al. (2002)
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ASF1 sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant) Green EM, et al (2005)
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run VAM3 sample: hx2 Hao Xu, et al. (2010)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #01 Alpha factor Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #09 Alpha Factor Prep4-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172]
    [364..382]    		 PSI-BLAST 2770.0 Heat shock protein 70kDa, ATPase fragment
    2 View Details [173..228]
    [304..363]    		 PSI-BLAST 2770.0 Heat shock protein 70kDa, ATPase fragment
    3 View Details [229..303] PSI-BLAST 2770.0 Heat shock protein 70kDa, ATPase fragment
    4 View Details [383..540] PSI-BLAST 734.0 DnaK
    5 View Details [541..642] ORFEUS 8.94 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.97191512372019 bayes_pls_golite062009
  • structural molecule activity
    		•  3.59589495899762 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • hydrolase activity
    		•  1.88613511243568 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.53527958884988 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.186218331473028 bayes_pls_golite062009
  • chromatin binding
    		•  0.155140608043269 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle