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A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. A process by which a protein is transported to, or maintained in, a location within an organelle. The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. The directed movement of substances within a cell. The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane. The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. The import of proteins into the space between the inner and outer mitochondrial membranes. A process by which a protein is transported to, or maintained in, a location within the mitochondrion. The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. The directed movement of proteins into a cell or organelle. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. Transport of substances into, out of or within a mitochondrion.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein targeting to mitochondrion
Acc: GO:0006626
Aspect: Biological Process
Desc: The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
Synonyms:
  • protein-mitochondrial targeting
  • protein import into mitochondrion
  • protein targeting to mitochondria
  • GO:0043681
  • mitochondrial protein import
  • mitochondrial translocation
Proteins in PDR annotated with:
   This term: 94 [Search]
   Term or descendants: 248 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006626 - protein targeting to mitochondrion (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle