YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	54 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CSI1	signalosome	protein deneddylation adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	molecular_function
CSN9	signalosome	protein deneddylation adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	molecular_function
ERV46	integral to Golgi membrane integral to endoplasmic reticulum membrane ER to Golgi transport vesicle	ER to Golgi vesicle-mediated transport	molecular_function
FPR2	endoplasmic reticulum membrane	biological_process	peptidyl-prolyl cis-trans isomerase activity
HUL5	nucleus cytoplasm	protein polyubiquitination protein monoubiquitination	ubiquitin-protein ligase activity
IQG1	cellular bud neck contractile ring	response to osmotic stress cytokinesis actin filament organization	cytoskeletal protein binding
MOT1	mitochondrion nuclear chromosome nuclear outer membrane	transcription of nuclear rRNA large RNA polymerase I transcript regulation of RNA polymerase II transcriptional preinitiation complex assembly regulation of transcription from RNA polymerase II promoter	ATPase activity rDNA binding TATA-binding protein binding
MPT5	cytoplasm	protein targeting loss of chromatin silencing involved in replicative cell aging cellular cell wall organization replicative cell aging nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay re-entry into mitotic cell cycle after pheromone arrest	mRNA binding
NAS6	proteasome regulatory particle	proteolysis	molecular_function
NMD3	cytosol	ribosomal large subunit export from nucleus ribosome biogenesis ribosomal large subunit assembly	RNA binding protein binding
NPT1	nucleus	chromatin silencing at rDNA replicative cell aging chromatin silencing at telomere nicotinate nucleotide salvage	nicotinate phosphoribosyltransferase activity
PCI8	signalosome	protein deneddylation	molecular_function
PEP1	Golgi apparatus	vacuolar transport protein targeting to vacuole	signal sequence binding
PST1	fungal-type cell wall plasma membrane	response to acid cellular cell wall organization	molecular_function
PUS9	nucleus cytoplasm mitochondrion	tRNA pseudouridine synthesis	RNA binding pseudouridine synthase activity isomerase activity
RPN1	nucleus proteasome regulatory particle, base subcomplex cytoplasm endoplasmic reticulum	ubiquitin-dependent protein catabolic process	endopeptidase activity protein binding, bridging
RPN10	proteasome regulatory particle, base subcomplex proteasome complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN11	nucleus proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN12	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN13	proteasome regulatory particle, lid subcomplex	proteolysis	endopeptidase activity
RPN14	cytoplasm proteasome regulatory particle	proteolysis ubiquitin-dependent protein catabolic process	molecular_function
RPN2	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity protein binding, bridging
RPN5	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN6	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPN7	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPN8	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN9	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPT1	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT2	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT3	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT4	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT5	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT6	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RRI1	signalosome	protein deneddylation adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	metalloendopeptidase activity
RRI2	signalosome	protein deneddylation adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	molecular_function
SEC18	cytoplasm extrinsic to plasma membrane	vacuole inheritance ER to Golgi vesicle-mediated transport vacuole fusion, non-autophagic	ATPase activity
SEM1	nucleus microsome cytosol proteasome regulatory particle, lid subcomplex	filamentous growth proteasomal ubiquitin-dependent protein catabolic process telomere maintenance exocytosis ubiquitin-dependent protein catabolic process	molecular_function
SKP1	RAVE complex nucleus cytoplasm CBF3 complex SCF ubiquitin ligase complex kinetochore	G2/M transition of mitotic cell cycle protein complex assembly regulation of exit from mitosis G1/S transition of mitotic cell cycle cytokinesis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of protein complex assembly protein neddylation kinetochore assembly vacuolar acidification protein ubiquitination during ubiquitin-dependent protein catabolic process	DNA replication origin binding ubiquitin-protein ligase activity protein binding
SPG5	cellular_component	biological_process	molecular_function
SPO77	intracellular	ascospore formation ascospore wall assembly	molecular_function
SQT1	cytoplasm cytosol	ribosome biogenesis ribosomal large subunit assembly	molecular_function
SWA2	endoplasmic reticulum membrane	telomere maintenance endoplasmic reticulum organization	protein binding
TCB2	cellular bud	biological_process	molecular_function
TIP41	nucleus cytoplasm	signal transduction	molecular_function
TOD6	nucleus cytoplasm	ribosome biogenesis	molecular_function
TOR2	TORC2 complex mitochondrion extrinsic to internal side of plasma membrane vacuolar membrane TORC1 complex plasma membrane	cytoskeleton organization regulation of cell growth signal transduction G1 phase of mitotic cell cycle ribosome biogenesis Rho protein signal transduction endocytosis actin filament reorganization involved in cell cycle establishment or maintenance of actin cytoskeleton polarity	protein binding protein serine/threonine kinase activity 1-phosphatidylinositol-3-kinase activity
TSR4	cytoplasm	biological_process	molecular_function
UBP6	proteasome regulatory particle	protein deubiquitination	ubiquitin-specific protease activity
YEN1	nucleus	biological_process	single-stranded DNA specific endodeoxyribonuclease activity
YKL027W	mitochondrion mitochondrial outer membrane	biological_process	molecular_function
YMR258C	nucleus cytoplasm	biological_process	molecular_function
YNL022C	nucleus	ribosome biogenesis	molecular_function
YPR003C	endoplasmic reticulum	biological_process	molecular_function
YPT52	late endosome	endocytosis protein targeting to vacuole	GTPase activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteasome accessory complex	1.157E-43	54	23	21	6292
proteasome regulatory particle	1.157E-43	54	23	21	6292
proteasome complex	8.995E-33	54	48	21	6292
proteasome regulatory particle, base subcomplex	1.2557E-19	54	9	9	6292
proteasome regulatory particle, lid subcomplex	1.2476E-18	54	10	9	6292
signalosome	7.9895E-10	54	7	5	6292
protein complex	1.7224E-8	54	1137	28	6292
macromolecular complex	4.0936E-5	54	1635	28	6292
intracellular	1.7296E-3	54	4975	51	6292
cell part	2.4381E-3	54	5397	53	6292
cell	2.4818E-3	54	5399	53	6292
intracellular part	4.8902E-3	54	4938	50	6292
extrinsic to plasma membrane	9.0541E-3	54	17	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteolysis	6.921E-19	54	188	21	6292
modification-dependent protein catabolic process	8.9721E-18	54	156	19	6292
ubiquitin-dependent protein catabolic process	8.9721E-18	54	156	19	6292
proteolysis involved in cellular protein catabolic process	1.2965E-17	54	159	19	6292
modification-dependent macromolecule catabolic process	2.3546E-17	54	164	19	6292
cellular protein catabolic process	5.2522E-17	54	171	19	6292
protein catabolic process	3.533E-16	54	189	19	6292
cellular macromolecule catabolic process	1.3477E-14	54	265	20	6292
macromolecule catabolic process	9.9135E-14	54	294	20	6292
cellular catabolic process	6.1665E-11	54	415	20	6292
protein deneddylation	2.2976E-10	54	6	5	6292
catabolic process	1.5079E-9	54	496	20	6292
protein metabolic process	1.6881E-8	54	1136	28	6292
adaptation of signaling pathway	7.2771E-8	54	14	5	6292
adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	7.2771E-8	54	14	5	6292
cellular protein metabolic process	1.1756E-7	54	1074	26	6292
protein modification by small protein removal	1.227E-7	54	29	6	6292
regulation of signaling pathway	3.2612E-6	54	28	5	6292
protein modification by small protein conjugation or removal	4.716E-6	54	114	8	6292
macromolecule metabolic process	3.1527E-4	54	2349	33	6292
response to pheromone involved in conjugation with cellular fusion	4.4878E-4	54	76	5	6292
cellular macromolecule metabolic process	1.226E-3	54	2285	31	6292
response to pheromone	1.3663E-3	54	97	5	6292
cellular response to chemical stimulus	2.1125E-3	54	107	5	6292
regulation of protein complex assembly	3.7842E-3	54	11	2	6292
conjugation with cellular fusion	4.1485E-3	54	125	5	6292
conjugation	4.2921E-3	54	126	5	6292
signaling pathway	4.6396E-3	54	184	6	6292
signaling	5.3832E-3	54	252	7	6292
response to organic substance	6.1152E-3	54	137	5	6292
multi-organism process	7.3121E-3	54	143	5	6292
regulation of RNA polymerase II transcriptional preinitiation complex assembly	8.5823E-3	54	1	1	6292
regulation of transcription initiation from RNA polymerase II promoter	8.5823E-3	54	1	1	6292
RNA polymerase II transcriptional preinitiation complex assembly	8.5823E-3	54	1	1	6292
transcription of nuclear rRNA large RNA polymerase I transcript	8.5823E-3	54	1	1	6292
transcriptional preinitiation complex assembly	8.5823E-3	54	1	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
endopeptidase activity	2.4893E-16	54	54	13	6292
peptidase activity, acting on L-amino acid peptides	2.3689E-14	54	95	14	6292
peptidase activity	4.2052E-10	54	192	14	6292
hydrolase activity	3.6971E-4	54	911	18	6292
ATPase activity	3.8562E-4	54	211	8	6292
nucleoside-triphosphatase activity	1.7268E-3	54	329	9	6292
hydrolase activity, acting on acid anhydrides	2.7984E-3	54	353	9	6292
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.7984E-3	54	353	9	6292
pyrophosphatase activity	2.7984E-3	54	353	9	6292
nicotinate phosphoribosyltransferase activity	8.5823E-3	54	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis