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Protein Overview: CTR9

General Information:
Name(s) found: CTR9 / YOL145C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1077 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    transcription elongation factor complex [IPILink to PubMed article]
    Cdc73/Paf1 complex [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: histone methylation [IMPLink to PubMed article]
    transcription from RNA polymerase II promoter [IPILink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: RNA polymerase II transcription elongation factor activity [IPILink to PubMed article]
    triplex DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNAMKVEGY PSMEWPTSLD IPLKASEELV GIDLETDLPD DPTDLKTLLV EENSEKEHWL  60
   61 TIALAYCNHG KTNEGIKLIE MALDVFQNSE RASLHTFLTW AHLNLAKGQS LSVETKEHEL 120
  121 TQAELNLKDA IGFDPTWIGN MLATVELYYQ RGHYDKALET SDLFVKSIHA EDHRSGRQSK 180
  181 PNCLFLLLRA KLLYQKENYM ASLKIFQELL VINPVLQPDP RIGIGLCFWQ LKDSKMAIKS 240
  241 WQRALQLNPK NTSASILVLL GEFRESFTNS TNDKTFKEAF TKALSDLNNI FSENQHNPVL 300
  301 LTLLQTYYYF KGDYQTVLDI YHHRILKMSP MIAKIVLSES SFWCGRAHYA LGDYRKSFIM 360
  361 FQESLKKNED NLLAKLGLGQ TQIKNNLLEE SIITFENLYK TNESLQELNY ILGMLYAGKA 420
  421 FDAKTAKNTS AKEQSNLNEK ALKYLERYLK LTLATKNQLV ISRAYLVISQ LYELQNQYKT 480
  481 SLDYLSKALE EMEFIKKEIP LEVLNNLACY HFINGDFIKA DDLFKQAKAK VSDKDESVNI 540
  541 TLEYNIARTN EKNDCEKSES IYSQVTSLHP AYIAARIRNL YLKFAQSKIE DSDMSTEMNK 600
  601 LLDLNKSDLE IRSFYGWYLK NSKERKNNEK STTHNKETLV KYNSHDAYAL ISLANLYVTI 660
  661 ARDGKKSRNP KEQGKSKHSY LKAIQLYQKV LQVDPFNIFA AQGLAIIFAE SKRLGPALEI 720
  721 LRKVRDSLDN EDVQLNLAHC YLEMREYGKA IENYELVLKK FDNEKTRPHI LNLLGRAWYA 780
  781 RAIKETSVNF YQKALENAKT ALDLFVKESS KSKFIHSVKF NIALLHFQIA ETLRRSNPKF 840
  841 RTVQQIKDSL EGLKEGLELF RELNDLKEFN MIPKEELEQR IQLGETTMKS ALERSLNEQE 900
  901 EFKKEQRAKI DEARKILEEN ELKEQGWMKQ EEEARRLKLE KQAEEYRKLQ DEAQKIFQVR 960
  961 EAMAISEHNV KDDSDLSDKD NEYDEEQPRQ KRKRSTKTKN SGESKRRKAA KKTLSDSDED1020
 1021 DDDVVKKPSH NKGKKSQLSN EFIEDSDEEE AQMSGSEQNK NDDNDENNDN DDNDGLF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC73 CKA1 CKA2 CKB1 CKB2 CTR9 LEO1 PAF1 POB3 RTF1 SPT16
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W
    View Details Gavin AC, et al. (2002) AVO1 BEM2 CDC73 CEG1 CET1 CKA1 CKA2 CKB1 CKB2 CLU1 CMD1 CSL4 CTR9 DIS3 ECM16 GCN1 HHF1, HHF2 IML1 LEO1 LSM12 LYS12 MAM33 MLC1 MTR3 MYO2 NIP1 NMD5 NOP1 PAF1 PDB1 POB3 PRP43 RPG1 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 RTF1 SAM1 SHE4 SKI6 SKI7 SPT16 SRP1 SSA3 SSA4 TOP2 UTP10 VPS1
    View Details Qiu et al. (2008) CDC73 CTR9 ELC1 LEO1 PAF1 SPN1 SPT4 SPT6 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRE2 CTR9 2 Unpublished Fields Lab Data
    View Screen HMT1 CTR9 1 Unpublished Fields Lab Data
    View Screen PRP42 CTR9 1 Unpublished Fields Lab Data
    View Screen RAD6 CTR9 1 Unpublished Fields Lab Data
    View Screen RCY1 CTR9 1 Unpublished Fields Lab Data
    View Screen COF1 CTR9 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CTR9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] PSI-BLAST 2.39794 Hop
    2 View Details [129..266] PSI-BLAST 33.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [267..352] PSI-BLAST 33.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [353..491] PSI-BLAST 33.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [492..543] deduced N/A No confident structure predictions are available.
    6 View Details [544..629] PSI-BLAST 2.30103 Protein farnesyltransferase alpha-subunit
    7 View Details [630..688] PSI-BLAST 2.30103 Protein farnesyltransferase alpha-subunit
    8 View Details [689..810] PSI-BLAST 4.221849 Heavy meromyosin subfragment
    9 View Details [811..1077] PSI-BLAST 4.221849 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription elongation regulator activity
    		•  5.39627565324437 bayes_pls_golite062009
  • RNA polymerase II transcription elongation factor activity
    		•  3.27203876848788 bayes_pls_golite062009
  • binding
    		•  2.45002000313605 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36976362065221 bayes_pls_golite062009
  • DNA binding
    		•  1.72247907299633 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63537681687141 bayes_pls_golite062009
  • protein binding
    		•  1.41340296563325 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0205750374806 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.597017459591015 bayes_pls_golite062009
  • transcription factor binding
    		•  0.447234745044969 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.36489074781643 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.201108481303385 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0645101607447045 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0514451541233234 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.0217632433282022 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle