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Protein Overview: IMD4

General Information:
Name(s) found: IMD4 / YML056C [SGD]
Description(s) found:
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  • gi|6323585|ref|NP_013656.1| Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; Imd4p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|577140|emb|CAA86719.1| putative inosine-5'-monophoshate dehydrogenase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1708478|sp|P50094.1|IMDH4_YEAST RecName: Full=Probable inosine-5'-monophosphate dehydrogenase IMD4; Short=IMP dehydrogenase; Short=IMPDH; Short=IMPD [NCBI NR]
  • pir||S50890 IMP dehydrogenase (EC 1.1.1.205) YML056c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Probable inosine-5'-monophosphate dehydrogenase IMD4 OS=Saccharomyces cerevisiae GN=IMD4 PE=1 SV=1 [Swiss-Prot]
  • (P50094) Probable inosine-5'-monophosphate dehydrogenase IMD4 (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD) [Swiss-Prot]
  • IMD4 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis [mips]
  • Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [SGD]
  • IMD4, Chr XIII from 162194-162653,163062-164176, reverse complement [yeast_orfs2]
  • Chr XIII from 162194-162653,163062-164176, reverse complement [yeastorf3.fasta]
  • Chr XIII from 164176-163717,163308-162194, reverse complement [yeastorf5.fasta]
  • IMD4 SGDID:S0004520, Chr XIII from 164176-163717,163308-162194, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Imd4p [Saccharomyces cerevisiae]gi|577140|emb|CAA86719.1| putative inosine-5'-monophoshate dehydrogenase [Saccharomyces cerevisiae]gi|1708478|sp|P50094|IMD4_YEAST Probable inosine-5'-monophosphate dehydrogenase IMD4 (IMP dehydrogenase) (IMPDH) (IMPD)gi [nrdb_11152004_Chlamydomonas]
  • IMD4 SGDID:S000004520, Chr XIII from 164176-163717,163308-162194, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Probable inosine-5'-monophosphate dehydrogenase IMD4 (IMP dehydrogenase) (IMPDH) (IMPD) [nr-271106-contam.fasta]
  • putative inosine-5'-monophoshate dehydrogenase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; Imd4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • IMD4 SGDID:S000004520, Chr XIII from 164176-163717,163308-162194, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Inosine-5'-monophosphate dehydrogenase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IMD4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • IMD4 SGDID:S000004520, Chr XIII from 163308-162194,164176-163717, Genome Release 64-1-1, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed" [yeast-030211-contam.fasta]
  • IMD4 SGDID:S000004520, Chr XIII from 163308-162194,164176-163717, Genome Release 64-2-1, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YML056C SGDID:S000004520, Chr XIII from 163308-162194,164176-163717, Genome Release 64-1-1, reverse complement, Verified ORF, "Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 524 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: IMP dehydrogenase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAPLDYKK ALEHLKTYSS KDGLSVQELM DSTTRGGLTY NDFLVLPGLV NFPSSAVSLQ  60
   61 TKLTKKITLN TPFVSSPMDT VTEADMAIYM ALLGGIGFIH HNCTPKEQAS MVKKVKMFEN 120
  121 GFINSPIVIS PTTTVGEVKV MKRKFGFSGF PVTEDGKCPG KLVGLVTSRD IQFLEDDSLV 180
  181 VSEVMTKNPV TGIKGITLKE GNEILKQTKK GKLLIVDDNG NLVSMLSRAD LMKNQNYPLA 240
  241 SKSATTKQLL CGAAIGTIEA DKERLRLLVE AGLDVVILDS SQGNSVFQLN MIKWIKETFP 300
  301 DLEIIAGNVA TREQAANLIA AGADGLRIGM GSGSICITQE VMACGRPQGT AVYNVCQFAN 360
  361 QFGVPCMADG GVQNIGHITK ALALGSSTVM MGGMLAGTTE SPGEYFYKDG KRLKAYRGMG 420
  421 SIDAMQKTGN KGNASTSRYF SESDSVLVAQ GVSGAVVDKG SIKKFIPYLY NGLQHSCQDI 480
  481 GCESLTSLKE NVQNGEVRFE FRTASAQLEG GVHNLHSYEK RLYN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 IMD1 IMD2 IMD3 IMD4 KEM1 KRE33 RPL15A RPL20B RPS11A, RPS11B RPS24A, RPS24B RPS4B, RPS4A RPS8B, RPS8A SRO9 STM1 UTP22 YAR075W
    View Details Krogan NJ, et al. (2006) COX18 IMD1 IMD2 IMD3 IMD4 PDE2 YAR075W
    View Details Gavin AC, et al. (2006) IMD4 TDH1
    View Details Ho Y, et al. (2002) AAC3 AI1 AIM46 AIR1 AIR2 ARE1 BCP1 BUD32 CAR2 CDC12 CDC33 CPR6 CRM1 CYS4 DED1 DIA4 DOG1 DOG2 EBP2 ELA1 FET4 FUN12 GRS1 GRX3 GRX4 GUS1 HAS1 HEF3 HHF1, HHF2 HHO1 HRB1 IDP2 IMD1 IMD2 IMD3 IMD4 KAE1 KRE33 KRI1 MAG1 MAG2 MET6 MGM101 MKK2 MPH1 MSC3 MSH2 MSK1 MSS116 MTR4 NAP1 NOC2 NOG1 NOP1 NOP12 NOP4 NOP53 NOP56 NOP7 NPA3 NPL3 OYE2 PAP2 PDC6 PET127 PHO81 POL30 PSE1 PUF6 PWP1 PYC1 RET1 RGD1 RKM1 RNH202 RPC82 RPF2 RPL23B, RPL23A RPN1 RPN5 RPN6 RPT1 RRP12 SEC18 SEC23 SEC53 SGO1 SMC6 SRP1 TIF4631 TIF4632 TIS11 TMA19 TMA29 URA7 UTP22 VMA22 YER077C YHR033W YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IMD4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..524] PSI-BLAST 10146.0 Inosine monophosphate dehydrogenase (IMPDH)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP dehydrogenase activity
    		•  2.02048863053452 bayes_pls_golite062009
  • binding
    		•  0.964202692685807 bayes_pls_golite062009
  • transporter activity
    		•  0.961062314616209 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.807029018941177 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.640881170978843 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.525366315833255 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.440262824681055 bayes_pls_golite062009
  • protein binding
    		•  0.22179604283012 bayes_pls_golite062009
  • catalytic activity
    		•  0.181756622780318 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.0973526732376297 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle