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Protein Overview: YSH1

General Information:
Name(s) found: YSH1 / YLR277C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 779 amino acids

    Gene Ontology:
    Cellular Component: mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed articleLink to PubMed article]
    mRNA cleavage factor complex [IPILink to PubMed article]
    Biological Process: mRNA polyadenylation [IDALink to PubMed article][TASLink to PubMed article]
    mRNA cleavage [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: RNA binding [ICLink to PubMed article]
    endoribonuclease activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERTNTTTFK FFSLGGSNEV GRSCHILQYK GKTVMLDAGI HPAYQGLASL PFYDEFDLSK  60
   61 VDILLISHFH LDHAASLPYV MQRTNFQGRV FMTHPTKAIY RWLLRDFVRV TSIGSSSSSM 120
  121 GTKDEGLFSD EDLVDSFDKI ETVDYHSTVD VNGIKFTAFH AGHVLGAAMF QIEIAGLRVL 180
  181 FTGDYSREVD RHLNSAEVPP LSSNVLIVES TFGTATHEPR LNRERKLTQL IHSTVMRGGR 240
  241 VLLPVFALGR AQEIMLILDE YWSQHADELG GGQVPIFYAS NLAKKCMSVF QTYVNMMNDD 300
  301 IRKKFRDSQT NPFIFKNISY LRNLEDFQDF GPSVMLASPG MLQSGLSRDL LERWCPEDKN 360
  361 LVLITGYSIE GTMAKFIMLE PDTIPSINNP EITIPRRCQV EEISFAAHVD FQENLEFIEK 420
  421 ISAPNIILVH GEANPMGRLK SALLSNFASL KGTDNEVHVF NPRNCVEVDL EFQGVKVAKA 480
  481 VGNIVNEIYK EENVEIKEEI AAKIEPIKEE NEDNLDSQAE KGLVDEEEHK DIVVSGILVS 540
  541 DDKNFELDFL SLSDLREHHP DLSTTILRER QSVRVNCKKE LIYWHILQMF GEAEVLQDDD 600
  601 RVTNQEPKVK EESKDNLTNT GKLILQIMGD IKLTIVNTLA VVEWTQDLMN DTVADSIIAI 660
  661 LMNVDSAPAS VKLSSHSCDD HDHNNVQSNA QGKIDEVERV KQISRLFKEQ FGDCFTLFLN 720
  721 KDEYASNKEE TITGVVTIGK STAKIDFNNM KILECNSNPL KGRVESLLNI GGNLVTPLC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PCF11 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 YSH1 YTH1
    View Details (MIPS) Mewes HW, et al. (2004) CFT1 CFT2 FIP1 PTA1 YSH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2006) CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Qiu et al. (2008) CFT1 CFT2 CLP1 HRP1 PAP1 PFS2 PTA1 REF2 RNA14 RNA15 SSU72 SWD2 YSH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 YSH1 1 Unpublished Fields Lab Data
    View Screen CTF13 YSH1 1 Unpublished Fields Lab Data
    View Screen SWI5 YSH1 1 Unpublished Fields Lab Data
    View Screen SPE1 YSH1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YSH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 14.522879 Zn metallo-beta-lactamase
    2 View Details [171..431] MSA 4.502993 View MSA. No confident structure predictions are available.
    3 View Details [432..529] MSA 1.114992 View MSA. No confident structure predictions are available.
    4 View Details [530..779] MSA 2.052967 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle