Protein Overview: VPS13

General Information:
Name(s) found:	VPS13 / YLL040C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322988\|ref\|NP_013060.1\| Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention; Vps13p [S [NCBI NR] gi\|2499125\|sp\|Q07878.1\|VPS13_YEAST RecName: Full=Vacuolar protein sorting-associated protein 13; AltName: Full=Suppression of the onset of impotence protein 1; AltName: Full=Vacuolar protein-targeting protein 2 [NCBI NR] gi\|2155302\|gb\|AAC08284.1\| Soi1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64791 VPS13 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1360233\|emb\|CAA97491.1\| VPS13 [Saccharomyces cerevisiae] [NCBI NR] Vacuolar protein sorting-associated protein 13 OS=Saccharomyces cerevisiae GN=VPS13 PE=1 SV=1 [Swiss-Prot] (Q07878) Vacuolar protein sorting-associated protein VPS13 [Swiss-Prot] VPS13 Protein involved in regulating membrane traffic [mips] Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention [SGD] VPS13, Chr XII from 54210-63644, reverse complement [yeast_orfs2] Chr XII from 54210-63644, reverse complement [yeastorf3.fasta] Chr XII from 63644-54210, reverse complement [yeastorf5.fasta] VPS13 SGDID:S0003963, Chr XII from 63644-54210, reverse complement, Verified ORF [yeastflysequest.fasta] Vps13p [Saccharomyces cerevisiae]gi\|1360233\|emb\|CAA97491.1\| VPS13 [Saccharomyces cerevisiae]gi\|2132654\|pir\|\|S64791 VPS13 protein - yeast (Saccharomyces cerevisiae)gi\|2155302\|gb\|AAC08284.1\| Soi1p [Saccharomyces cerevisiae]gi\|2499125\|sp\|Q07878\|VP13_YEAS [nrdb_11152004_Chlamydomonas] VPS13 SGDID:S000003963, Chr XII from 63644-54210, reverse complement, Verified ORF, "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuol [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Vacuolar protein sorting-associated protein 13 (Suppression of the onset of impotence protein 1) (Vacuolar protein-targeting protein 2) [nr-271106-contam.fasta] Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention; Vps13p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Soi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] VPS13 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] VPS13 SGDID:S000003963, Chr XII from 63644-54210, reverse complement, Verified ORF, "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Vacuolar protein sorting-associated protein 13 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS13 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] VPS13 SGDID:S000003963, Chr XII from 63645-54211, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention" [yeast-030211-contam.fasta] VPS13 SGDID:S000003963, Chr XII from 63645-54211, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein involved in prospore membrane morphogenesis; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulatoin, and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively" [20141208_orf_trans.fasta] YLL040C SGDID:S000003963, Chr XII from 63645-54211, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	3144 amino acids
Gene Ontology:
Cellular Component:	endosome [IDA] mitochondrion [IDA ] extrinsic to membrane [IDA]
Biological Process:	ascospore formation [IMP] protein retention in Golgi apparatus [IMP] late endosome to vacuole transport [IGI][IMP] vacuolar protein catabolic process [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLESLAANLL NRLLGSYVEN FDPNQLNVGI WSGDVKLKNL KLRKDCLDSL NLPIDVKSGI  60
   61 LGDLVLTVPW SSLKNKPVKI IIEDCYLLCS PRSEDHENDE EMIKRAFRLK MRKVSEWELT 120
  121 NQARILSTQS ENKTSSSSSE KNNAGFMQSL TTKIIDNLQV TIKNIHLRYE DMDGIFTTGP 180
  181 SSVGLTLNEL SAVSTDSNWA PSFIDITQNI THKLLTLNSL CLYWNTDSPP LISDDDQDRS 240
  241 LENFVRGFKD MIASKNSTAP KHQYILKPVS GLGKLSINKL GSTEEQPHID LQMFYDEFGL 300
  301 ELDDTEYNDI LHVLSSIQLR QITKKFKKAR PSFAVSENPT EWFKYIAACV INEIHEKNKM 360
  361 WTWESMKEKC EQRRLYTKLW VEKLKLKNLE APLRDPIQEA QLSELHKDLT YDEIILFRSV 420
  421 AKRQYAQYKL GMTEDSPTPT ASSNIEPQTS NKSATKNNGS WLSSWWNGKP TEEVDEDLIM 480
  481 TEEQRQELYD AIEFDENEDK GPVLQVPRER VELRVTSLLK KGSFTIRKKK QNLNLGSIIF 540
  541 ENCKVDFAQR PDSFLSSFQL NKFSLEDGSP NALYKHIISV RNSSKDQSSI DNHATGEEEE 600
  601 EDEPLLRASF ELNPLDGLAD SNLNIKLLGM TVFYHVHFIT EVHKFFKASN QHMETIGNIV 660
  661 NAAEATVEGW TTQTRMGIES LLEDHKTVNV SLDLQAPLII LPLDPHDWDT PCAIIDAGHM 720
  721 SILSDLVPKE KIKEIKELSP EEYDKIDGNE INRLMFDRFQ ILSQDTQIFV GPDIQSTIGK 780
  781 INTASSTNDF RILDKMKLEL TVDLSILPKA YKLPTIRVFG HLPRLSLSIN DIQYKTIMNL 840
  841 IANSIPSMID DEENNGDYVN YSSGSEKEMK KQIQLQLKNT LKALENMQPL QIEQKFLELH 900
  901 FDIDQAKIAF FQCIKNDSRN SEKLVDILCQ RLNFNFDKRA KEMNLDLRVH SLDVEDYIEL 960
  961 TDNKEFKNLI SSGVEKVTRS QKDLFTLKYK RVQRIVPHND TLIELFDQDI VMHMSELQLV1020
 1021 LTPRSVLTLM NYAMLTFTDP NAPEMPADVL RHNKEDRDDA PQKINMKIKM EAVNVIFNDD1080
 1081 SIKLATLVLS AGEFTMVLLP ERYNINLKLG GLELTDETNE SFSRDSVFRK IIQMKGQELV1140
 1141 ELSYESFDPA TNTKDYDSFL KYSTGSMHVN FIESAVNRMV NFFAKFQKSK VSFDRARLAA1200
 1201 YNQAPSIDAV NNMKMDIVIK APIIQFPKLV GTQENNYDTM RFYLGEFFIE NKFSVIDESH1260
 1261 KINHIKLGVR EGQLSSNLNF DGSSQQLYLV ENIGLLFNID RDPLPQDDTP ELKVTSNFES1320
 1321 FALDLTENQL TYLLEISNKV SSAFNITDEN SGESGGKGEI KSPSPDPASL SSESERTATP1380
 1381 QSLQGSNKSN IKNPEQKYLD FSFKAPKIAL TLYNKTKGVT SLNDCGLTRI MFQDIGCSLG1440
 1441 LKNDGTVDGQ AHVAAFRIED VRNIKDNKHT ELIPKSKNKE YQFVANISRK NLEVGRLLNI1500
 1501 SMTMDSPKMI LAMDYLVSLK EFFDAIMSKS HENNLYYPEN TNQKPENKAI VESVQEGGDV1560
 1561 TKIQYSVNII ETALILLADP CDMNSEAISF KIGQFLVTDQ NIMTVAANNV GIFLFKMNSS1620
 1621 EEKLRLLDDF SSSLTIDKRN STPQTLMTNI QLSVQPLLMR ISLRDIRLAM LIFKRVTTLL1680
 1681 NKMTEKEDNG EEEESTDKIQ FSHEFERKLA VLDPSILGER SRASQSSDSE SIEVPTAILK1740
 1741 NETFNADLGG LRFILIGDVH EMPILDMNVN EITASAKDWS TDFEALASLE TYVNIFNYSR1800
 1801 SSWEPLLEMI PITFHLSKGH SEMDPAFSFD ILTQRIAEIT LSARSIAMLS HIPASLTEEL1860
 1861 PLASRVSQKP YQLVNDTELD FDVWIQDKTT EDNKNEVVLL KANTSLPWEF EDWRSIREKL1920
 1921 DIDKSKNILG VCVSGQNYKT IMNIDATTEG ENLHVLSPPR NNVHNRIVCE ARCDENNVKI1980
 1981 ITFRSTLVIE NTTSTEIELL VDSKDPNKPS LKYAIKPHQS KSVPVEYAYD SDIRIRPASE2040
 2041 DIYDWSQQTL SWKSLLSNQM SIFCSSKEDS NQRFHFEIGA KYDEREPLAK IFPHMKIVVS2100
 2101 ASMTIENLLP ADINFSIFDK REEKRTDFLK TGESMEVHHI SLDSFLLMSV QPLQDEASAS2160
 2161 KPSIVNTPHK SPLNPEDSLS LTLSGGQNLL LKLDYKNIDG TRSKVIRIYS PYIIMNSTDR2220
 2221 ELYIQSSLLN IAQSKILLEN EKRYTIPKMF SFDKEDDKSN RARIRFKESE WSSKLSFDAI2280
 2281 GQSFDASVRI KNKEQESNLG INISEGKGKY LLSKVIEIAP RYIISNTLDI PIEVCETGSM2340
 2341 DVQQIESNIT KPLYRMRNIV DKQLVLKFLG GDSNWSQPFF IKNVGVTYLK VLKNSRHKLL2400
 2401 KIEILLDKAT IFIRIKDGGD RWPFSIRNFS DHDFIFYQRD PRKVSDPYKD DQSNESSSRS2460
 2461 FKPIFYRIPS KSIMPYAWDF PTAKEKYLVL ESGTRTREVR LAEIGELPPL RLDKRSKDKP2520
 2521 APIVGLHVVA DDDMQALVIV NYKANVGLYK LKTASATTTS SVSVNSSVTD GFVQKDEDEK2580
 2581 VNTQIVVSFK GVGISLINGR LQELLYINMR GIELRYNESK AYQTFSWKMK WMQIDNQLFS2640
 2641 GNYSNILYPT EIPYTEKEIE NHPVISGSIS KVNDSLQAVP YFKHVTLLIQ EFSIQLDEDM2700
 2701 LYAMMDFIKF PGSPWIMDSR DYKYDEEIQL PDVSELKTAG DIYFEIFHIQ PTVLHLSFIR2760
 2761 SDEISPGLAE ETEESFSSSL YYVHMFAMTL GNINEAPVKV NSLFMDNVRV PLPILMDHIE2820
 2821 RHYTTQFVYQ IHKILGSADC FGNPVGLFNT ISSGVWDLFY EPYQGYMMND RPQEIGIHLA2880
 2881 KGGLSFAKKT VFGLSDSMSK FTGSMAKGLS VTQDLEFQRV RRLQQRINKN NRNALANSAQ2940
 2941 SFASTLGSGL SGIALDPYKA MQKEGAAGFL KGLGKGIVGL PTKTAIGFLD LTSNLSQGVK3000
 3001 STTTVLDMQK GCRVRLPRYV DHDQIIKPYD LREAQGQYWL KTVNGGVFMN DEYLSHVILP3060
 3061 GKELAVIVSM QHIAEVQMAT QELMWSTGYP SIQGITLERS GLQIKLKSQS EYFIPISDPE3120
 3121 ERRSLYRNIA IAVREYNKYC EAIL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		MUM2 VPS13
View Details	Gavin AC, et al. (2002)		CTF18 CTF8 DPB2 ELG1 OLA1 POL2 RFC1 RFC2 RFC3 RFC4 RFC5 TOP2 VPS13 YMR181C
View Details	Ho Y, et al. (2002)		ADR1 BBC1 BCY1 CDC39 CDC53 CMD1 CMK2 CMP2 COF1 CPR1 CRM1 DUR1,2 ECM29 ECM33 EDE1 FAA4 FET4 GAL3 GCN1 HCH1 HRT1 HYP2 ILS1 IPP1 MDN1 MKT1 MMS1 MYO2 MYO4 MYO5 PFK1 PGM2 PMA2 PST2 RIM15 RPA190 RPN1 SHE3 SOD1 TCP1 TPK1 TPK2 TPK3 TPS1 UBA1 UBI4 VAS1 VPS13 YAR009C YGP1 YLR035C-A YNK1 YPT35

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	KOG1	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	PAN1	No Comments	Toshima J, et al (2006)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#02 Alpha Factor Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	VPS13 and SNF7	Huh WK, et al. (2003)
View Data	VPS13	Huh WK, et al. (2003)

TMHMM	pre 2.0c	PSIPRED	pre v2.61
SignalP	pre 3.0	COILS	1999
DISOPRED	pre v0.2	NCBI nr	circa 2005
PSI-BLAST	~2.2.10	FFAS	ffas
PDB	~2005	Pfam	16
HMMER	2.3.1

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..394]	MSA	5.024958	View MSA. No confident structure predictions are available.
2	View Details	[395..473]	deduced	N/A	No confident structure predictions are available.
3	View Details	[474..863]	MSA	1.016912	View MSA. No confident structure predictions are available.
4	View Details	[864..1227]	deduced	N/A	No confident structure predictions are available.
5	View Details	[1228..1353]	MSA	1.015977	View MSA. No confident structure predictions are available.
6	View Details	[1354..1739]	deduced	N/A	No confident structure predictions are available.
7	View Details	[1740..1864]	MSA	1.015982	View MSA. No confident structure predictions are available.
8	View Details	[1865..2169]	deduced	N/A	No confident structure predictions are available.
9	View Details	[2170..2278]	MSA	2.019983	View MSA. No confident structure predictions are available.
10	View Details	[2279..2541]	MSA	1.020955	View MSA. No confident structure predictions are available.
11	View Details	[2542..2619]	deduced	N/A	Confident ab initio structure predictions are available.
12	View Details	[2620..3021]	MSA	4.033932	View MSA. No confident structure predictions are available.
13	View Details	[3022..3144]	deduced	N/A	Confident ab initio structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: VPS13

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: