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Protein Overview: GCN5

General Information:
Name(s) found: GCN5 / YGR252W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 439 amino acids

    Gene Ontology:
    Cellular Component: SLIK (SAGA-like) complex [IPILink to PubMed article]
    Ada2/Gcn5/Ada3 transcription activator complex [IPILink to PubMed article]
    SAGA complex [IDALink to PubMed article]
    Biological Process: chromatin modification [TASLink to PubMed article]
    histone acetylation [IMPLink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IDALink to PubMed article]
    transcription coactivator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTKHQIEED HLDGATTDPE VKRVKLENNV EEIQPEQAET NKQEGTDKEN KGKFEKETER  60
   61 IGGSEVVTDV EKGIVKFEFD GVEYTFKERP SVVEENEGKI EFRVVNNDNT KENMMVLTGL 120
  121 KNIFQKQLPK MPKEYIARLV YDRSHLSMAV IRKPLTVVGG ITYRPFDKRE FAEIVFCAIS 180
  181 STEQVRGYGA HLMNHLKDYV RNTSNIKYFL TYADNYAIGY FKKQGFTKEI TLDKSIWMGY 240
  241 IKDYEGGTLM QCSMLPRIRY LDAGKILLLQ EAALRRKIRT ISKSHIVRPG LEQFKDLNNI 300
  301 KPIDPMTIPG LKEAGWTPEM DALAQRPKRG PHDAAIQNIL TELQNHAAAW PFLQPVNKEE 360
  361 VPDYYDFIKE PMDLSTMEIK LESNKYQKME DFIYDARLVF NNCRMYNGEN TSYYKYANRL 420
  421 EKFFNNKVKE IPEYSHLID

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF5 TAF6 TAF9 TRA1 UBP8
    View Details (MIPS) Mewes HW, et al. (2004) ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 COG3 CSE2 ENO2 FAB1 FBA1 FUN19 GAL11 GCN5 HEM13 HFI1 KAP114 KAP123 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MES1 MLP1 MNN4 MOT1 MRPL6 MYO1 MYO4 NGG1 NOP1 NUT1 NUT2 PFK2 PGD1 PGK1 PSK1 PTC1 PUF6 RGR1 ROX3 RPB2 RPG1 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TIF1, TIF2 UBP8 VAS1 VPS1 YIL077C
    View Details Ho Y, et al. (2002) ADA2 FET4 GCN5 HFI1 SGF29 SPT7 TAF6 TRA1 UBP8
    View Details Qiu et al. (2008) ADA2 AHC1 ARP4 CHD1 EPL1 ESA1 GCN5 HFI1 NGG1 SAS3 SGF29 SGF73 SIN4 SPT20 SPT3 SPT7 SPT8 TAF10 TAF11 TAF12 TAF13 TAF14 TAF3 TAF5 TAF6 TAF9 TRA1 UBP8 YNG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT2 GCN5 1 Unpublished Fields Lab Data
    View Screen RRB1 GCN5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCN5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] deduced N/A No confident structure predictions are available.
    2 View Details [71..162]
    [176..191]    		 PSI-BLAST 993.045757 Catalytic domain of GCN5 histone acetyltransferase
    3 View Details [163..175]
    [192..234]    		 PSI-BLAST 993.045757 Catalytic domain of GCN5 histone acetyltransferase
    4 View Details [235..319] deduced N/A No confident structure predictions are available.
    5 View Details [320..439] PSI-BLAST 655.66807 GCN5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  10.330867741687 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  10.2097972775096 bayes_pls_golite062009
  • acetyltransferase activity
    		•  9.5414870492393 bayes_pls_golite062009
  • acyltransferase activity
    		•  8.84144467104026 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  8.80032457938662 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  8.58458341779614 bayes_pls_golite062009
    		• 7.30820970670781 bayes_pls_golite062009
  • H3 histone acetyltransferase activity
    		•  6.1481916320934 bayes_pls_golite062009
    		• 3.86052919290021 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.07485575332112 bayes_pls_golite062009
  • transferase activity
    		•  2.87429355361226 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.24760844790231 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13750665291344 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • binding
    		•  1.22537494136129 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.2180007740195 bayes_pls_golite062009
  • transcription factor binding
    		•  1.13174003342838 bayes_pls_golite062009
  • transcription activator activity
    		•  0.891911076312861 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.605899196605446 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.31196049232138 bayes_pls_golite062009
  • protein binding
    		•  0.075825416385311 bayes_pls_golite062009
  • RNA polymerase II transcription mediator activity
    		•  0.0178952175491798 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • histone acetyltransferase activity
    		•  9.91927576220387 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  9.91927576220387 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  7.57346092874507 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  7.12398761720889 bayes_pls_golite062009
  • acetyltransferase activity
    		•  6.51488433263281 bayes_pls_golite062009
  • acyltransferase activity
    		•  5.44980261163837 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  5.38368530556466 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  5.26899007107713 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  5.06705016462047 bayes_pls_golite062009
    		• 4.94702795409425 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.81944587687526 bayes_pls_golite062009
  • DNA binding
    		•  3.34863990009219 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.25178464591722 bayes_pls_golite062009
  • binding
    		•  3.24233563871512 bayes_pls_golite062009
  • histone binding
    		•  2.93206976627622 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.58609800997327 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.37993162280856 bayes_pls_golite062009
  • transcription factor binding
    		•  2.33866683789609 bayes_pls_golite062009
  • transcription activator activity
    		•  1.99519727421308 bayes_pls_golite062009
  • MyoD binding
    		•  1.89625280750577 bayes_pls_golite062009
  • MRF binding
    		•  1.89625280750577 bayes_pls_golite062009
  • chromatin binding
    		•  1.85568770971367 bayes_pls_golite062009
  • protein binding
    		•  1.82955314054861 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.82747962293997 bayes_pls_golite062009
  • protein kinase activity
    		•  1.63512839295568 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.60584871002187 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30026489619787 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.15145628425168 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.08961199627679 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.07760436003896 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.96034823197127 bayes_pls_golite062009
  • kinase activity
    		•  0.890638513095454 bayes_pls_golite062009
  • peroxisome proliferator activated receptor binding
    		•  0.547697825358481 bayes_pls_golite062009
  • structural molecule activity
    		•  0.398844600914114 bayes_pls_golite062009
  • transferase activity
    		•  0.321534577277088 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0167144924052265 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle