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View Structure Prediction Details

Protein: GCN5
Organism: Saccharomyces cerevisiae
Length: 439 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCN5.

Description E-value Query
Range		 Subject
Range
gi|207344919 - gi|207344919|gb|EDZ71903.1| YGR252Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GCN5_YEAST - Histone acetyltransferase GCN5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCN5 PE=1...
gi|190406742 - gi|190406742|gb|EDV10009.1| histone acetyltransferase [Saccharomyces cerevisiae RM11-1a]
GCN5 - Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit o...
 0.0 [1..439] [1..439]
gi|17017400, gi|... - gi|223949013|gb|ACN28590.1| unknown [Zea mays], gi|18447805|emb|CAD22097.1| histone acetyltransferas...
 0.0 [9..428] [64..504]
GCN5_ARATH - Histone acetyltransferase GCN5 OS=Arabidopsis thaliana GN=HAG1 PE=1 SV=1
 0.0 [1..429] [74..558]
gi|14317910 - gi|14317910|dbj|BAB59138.1| PCAF [Gallus gallus]
 0.0 [29..430] [335..754]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [26..430] [48..470]
GCN5L2 - GCN5 general control of amino-acid synthesis 5-like 2 (yeast)
 0.0 [26..430] [409..831]

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Predicted Domain #1
Region A:
Residues: [1-70] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTKHQIEED HLDGATTDPE VKRVKLENNV EEIQPEQAET NKQEGTDKEN KGKFEKETER  60
   61 IGGSEVVTDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [71-162] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKGIVKFEFD GVEYTFKERP SVVEENEGKI EFRVVNNDNT KENMMVLTGL KNIFQKQLPK  60
   61 MPKEYIARLV YDRSHLSMAV IRKPLTVVGG IT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [176-191] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FCAISSTEQV RGYGAH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 993.045757
Match: 1yghA_
Description: Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
N-acetyltransferase activity 10.330867741687 bayes_pls_golite062009
histone acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
lysine N-acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
N-acyltransferase activity 10.2097972775096 bayes_pls_golite062009
acetyltransferase activity 9.5414870492393 bayes_pls_golite062009
acyltransferase activity 8.84144467104026 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 8.80032457938662 bayes_pls_golite062009
transferase activity, transferring acyl groups 8.58458341779614 bayes_pls_golite062009
7.30820970670781 bayes_pls_golite062009
H3 histone acetyltransferase activity 6.1481916320934 bayes_pls_golite062009
3.86052919290021 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.07485575332112 bayes_pls_golite062009
transferase activity 2.87429355361226 bayes_pls_golite062009
transcription regulator activity 2.24760844790231 bayes_pls_golite062009
nucleic acid binding 2.13750665291344 bayes_pls_golite062009
catalytic activity 1.97933499002461 bayes_pls_golite062009
binding 1.22537494136129 bayes_pls_golite062009
transcription coactivator activity 1.2180007740195 bayes_pls_golite062009
transcription factor binding 1.13174003342838 bayes_pls_golite062009
transcription activator activity 0.891911076312861 bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity 0.774009286200155 bayes_pls_golite062009
myristoyltransferase activity 0.774009286200155 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.605899196605446 bayes_pls_golite062009
histone binding 0.582104626133107 bayes_pls_golite062009
transcription cofactor activity 0.31196049232138 bayes_pls_golite062009
protein binding 0.075825416385311 bayes_pls_golite062009
RNA polymerase II transcription mediator activity 0.0178952175491798 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [163-175] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRPFDKREFA EIV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [192-234] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMNHLKDYVR NTSNIKYFLT YADNYAIGYF KKQGFTKEIT LDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 993.045757
Match: 1yghA_
Description: Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [235-319] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIWMGYIKDY EGGTLMQCSM LPRIRYLDAG KILLLQEAAL RRKIRTISKS HIVRPGLEQF  60
   61 KDLNNIKPID PMTIPGLKEA GWTPE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone acetyltransferase activity 9.91927576220387 bayes_pls_golite062009
lysine N-acetyltransferase activity 9.91927576220387 bayes_pls_golite062009
N-acetyltransferase activity 7.57346092874507 bayes_pls_golite062009
N-acyltransferase activity 7.12398761720889 bayes_pls_golite062009
acetyltransferase activity 6.51488433263281 bayes_pls_golite062009
acyltransferase activity 5.44980261163837 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 5.38368530556466 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.26899007107713 bayes_pls_golite062009
transferase activity, transferring acyl groups 5.06705016462047 bayes_pls_golite062009
4.94702795409425 bayes_pls_golite062009
transcription regulator activity 3.81944587687526 bayes_pls_golite062009
DNA binding 3.34863990009219 bayes_pls_golite062009
nucleic acid binding 3.25178464591722 bayes_pls_golite062009
binding 3.24233563871512 bayes_pls_golite062009
histone binding 2.93206976627622 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.58609800997327 bayes_pls_golite062009
transcription coactivator activity 2.37993162280856 bayes_pls_golite062009
transcription factor binding 2.33866683789609 bayes_pls_golite062009
transcription activator activity 1.99519727421308 bayes_pls_golite062009
MyoD binding 1.89625280750577 bayes_pls_golite062009
MRF binding 1.89625280750577 bayes_pls_golite062009
chromatin binding 1.85568770971367 bayes_pls_golite062009
protein binding 1.82955314054861 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.82747962293997 bayes_pls_golite062009
protein kinase activity 1.63512839295568 bayes_pls_golite062009
transcription cofactor activity 1.60584871002187 bayes_pls_golite062009
transcription factor activity 1.30026489619787 bayes_pls_golite062009
protein serine/threonine kinase activity 1.15145628425168 bayes_pls_golite062009
sequence-specific DNA binding 1.08961199627679 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.07760436003896 bayes_pls_golite062009
transcription initiation factor activity 0.96034823197127 bayes_pls_golite062009
kinase activity 0.890638513095454 bayes_pls_golite062009
peroxisome proliferator activated receptor binding 0.547697825358481 bayes_pls_golite062009
structural molecule activity 0.398844600914114 bayes_pls_golite062009
transferase activity 0.321534577277088 bayes_pls_golite062009
transcription repressor activity 0.0167144924052265 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [320-439] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDALAQRPKR GPHDAAIQNI LTELQNHAAA WPFLQPVNKE EVPDYYDFIK EPMDLSTMEI  60
   61 KLESNKYQKM EDFIYDARLV FNNCRMYNGE NTSYYKYANR LEKFFNNKVK EIPEYSHLID 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 655.66807
Match: 1e6iA_
Description: GCN5
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle