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Protein Overview: REG1

General Information:
Name(s) found: REG1 / YDR028C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1014 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 1 complex [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    regulation of carbohydrate metabolic process [IGILink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    glycogen metabolic process [TASLink to PubMed article]
    vacuolar protein catabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein phosphatase type 1 regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNLANYFA GKKDIENEHV NRNASHESNS KSDVKISGND NDNDEDMGPS VSMAVQAKND  60
   61 DDFHKSTFNL KRTRSMGLLD EYIDPTKKLL GRSDDLYDND NEYYDNSSNN SSSNSSDDDY 120
  121 DDGYQEHSTS VSPPPADNDS YLIPQDDNDV VVEPERHVDY LSHEWKESEI SNSWKYIILK 180
  181 KKKRDVDLVN AARLENASWR TWAKARNNLK TVSPEVVNWS KDSDVTWLYG PIVRDSEGNA 240
  241 QSEEEHDLER GYGSDDENSK RISMPTKNSK SIAAAPKPIL KKRTVTEIIE DNALWKLNEA 300
  301 RKHMTEMKHA SVIMDPNGNK NVHDDFDALA AQVNAQYYHY PKESNSSVSL KSQHSDKKDN 360
  361 STIPNPVGEN SNGGGDKGEE DLHLKSALHV QNNRSTAQSN KSILENSTND RKANLDQNLN 420
  421 SPDNNRFPSS TSSSNRDNEN NSMGLSSILT SNPSEKSNKP TKNRHIHFND RVEQCMALRY 480
  481 PASQSEDDES DDENKQYVDV NNNANVTTIN NNRTPLLAIQ HKSIPINSAT EHLNKNTSDD 540
  541 DTSSQSSSSS HSDDEEHGGL YINARFSRRS DSGVHSPITD NSSVASSTTS RAHVRPIIKL 600
  601 LPDTTLNYGS DEESDNGEFN GYGNAVSHNV NTSRGYDYIY DYNSVYTGDT SSFLPVDSCD 660
  661 IVDVPEGMDL QTAIADDNAS NYEFNNAVES KEKHVPQLHK ASANNTTRQH GSHMLLYDDD 720
  721 NYSSSSDSEQ QFIEDSQYNS SDDEEEEDDD DQEVDDNHDE GLSLRRTLSL GKSGSTNSLY 780
  781 DLAQPSLSSA TPQQKNPTNF TGGKTDVDKD AQLAVRPYPL KRNSSSGNFI FNSDSEEESS 840
  841 SEEEQRPLPA NSQLVNRSVL KGSVTPANIS SQKKKALPKQ PKASDSSQSF RIVNNTPSPA 900
  901 EVGASDVAIE GYFSPRNESI KSVVSGGNMM DHQDHSEMDT LAKGFENCHI NNASKLKDKK 960
  961 VDSVQTTRKE ASLTDSSNES LHKVVQNARG MASKYLHSWK KSDVKPQENG NDSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMH1 GAL83 GLC7 GLC8 REG1 SDS22 SNF1 SNF4
    View Details (MIPS) Mewes HW, et al. (2004) GAC1 GIP2 GLC7 GLC8 REG1 SDS22
    View Details Krogan NJ, et al. (2006) ASK10 ATG1 BMH2 KIC1 NTH1 PIK1 REG1 RFX1 SOG2 UBP11 YDR348C YNR014W
    View Details Gavin AC, et al. (2006) GAL83 REG1 SIP1 SNF1 SNF4
    View Details Gavin AC, et al. (2002) BMH1 BNI1 CDC48 CKA1 CKB1 CTR3 DAL3 DOA1 GAL83 GLN1 GTO3 IML1 MCM2 MKS1 MRPS28 NPL4 PDC1 RAI1 REG1 RPA135 RPA190 RPO31 SAK1 SHP1 SIP1 SIP2 SNF1 SNF4 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 UFD1 YDR049W YIL177C
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CFT1 CIC1 CLU1 CSR2 CYK3 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 GSY1 GSY2 HER1 HXT6 KCS1 KEL1 KOG1 MHP1 NET1 NOP6 NOP7 NSA1 NSR1 NTH1 PMA1 PMA2 PPZ2 REG1 RRP17 RSE1 RVB1 SCD5 SDS22 SEN1 SNF4 SOK1 SPB1 STU1 SUI2 SUI3 SVL3 YFR017C YGR130C YIL028W YTM1
    View Details Qiu et al. (2008) GAC1 GIP1 GIP2 PIG1 REG1 REG2 TPS1 TPS3 TSL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data REG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..354] MSA 2.004977 View MSA. No confident structure predictions are available.
    3 View Details [355..774] deduced N/A No confident structure predictions are available.
    4 View Details [775..1014] MSA 1.002892 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle