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Protein Overview: USO1

General Information:
Name(s) found: USO1 / YDL058W [SGD]
Description(s) found:
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  • gi|6320145|ref|NP_010225.1| Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex; Uso1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|56757595|sp|P25386.2|USO1_YEAST RecName: Full=Intracellular protein transport protein USO1; Short=Int-1 [NCBI NR]
  • pir||S67593 transport protein USO1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431059|emb|CAA98621.1| USO1 [Saccharomyces cerevisiae] [NCBI NR]
  • Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae GN=USO1 PE=1 SV=2 [Swiss-Prot]
  • USO1 Intracellular protein transport protein [mips]
  • Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex [SGD]
  • USO1, Chr IV from 345664-351036 [yeast_orfs2]
  • Chr IV from 345664-351036 [yeastorf3.fasta]
  • >Q07380 (Q07380) Hypothetical protein YDL058W [4932.FASTACCERV.txt]
  • USO1 SGDID:S0002216, Chr IV from 345665-351037, Verified ORF [yeastflysequest.fasta]
  • Uso1p [Saccharomyces cerevisiae]gi|1431059|emb|CAA98621.1| USO1 [Saccharomyces cerevisiae]gi|2133190|pir||S67593 transport protein USO1 - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • USO1 SGDID:S000002216, Chr IV from 345665-351037, Verified ORF, "Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Intracellular protein transport protein USO1 (Int-1) [nr-271106-contam.fasta]
  • Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex; Uso1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • USO1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • USO1 SGDID:S000002216, Chr IV from 345665-351037, Genome Release 64-1-1, Verified ORF, "Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex" [yeast-030211-contam.fasta]
  • USO1 SGDID:S000002216, Chr IV from 345665-351037, Genome Release 64-2-1, Verified ORF, "Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex" [20141208_orf_trans.fasta]
  • YDL058W SGDID:S000002216, Chr IV from 345665-351037, Genome Release 64-1-1, Verified ORF, "Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1790 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    protein complex assembly [IDALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIIQGLIQQ PKIQSVDETI PTLCDRVENS TLISDRRSAV LGLKAFSRQY RESVIASGLK  60
   61 PLLNTLKRDY MDEDSVKAIL ETILILFIRG DGHDDLTRGW ISQQSRLQNG KYPSPLVMKQ 120
  121 EKEQVDQFSL WIADALTQSE DLIHLLVEFW EIDNFHIRLY TIQLLEAVMA TRPLKARSAL 180
  181 ISLPTSISTM VSLLDDMHEP IRDEAILLLM AVVNDSPHVQ KLVAFENIFE RLFSIIEEEG 240
  241 GLRGSLVVND CLSLINNILK YNTSNQTLFL ETGNLPKLAH LLSEPISQDE VFFWNDQRIV 300
  301 NINTALDIVS LTVEPGNTVT TKHQNALLDS SVLMVVLRLA FFHNIPKKVR PVALLTAANM 360
  361 VRSNEHAQLE FSKIDVPYFD PSLPVNSTAN GGPIKLIPVV SILINWMLYA NSVHTFDTRV 420
  421 ACSRLLKAYF MDNFDLQRDF LLKQVQLCNN STNNVGDNAK ENGGSNKSDK ESDSDKDTDG 480
  481 KDGTEYEGSF KANLFEVLLN YDAELNLNPF KLFFTTDIFM FFFQQDHKYS EELREITRNV 540
  541 TTGNDLEDEE PLKAIQTISE LLTTSLTAAD IRIPISYLTF LIYWLFGDFK ATNDFLSDKS 600
  601 VIKSLLSFSY QIQDEDVTIK CLVTMLLGVA YEFSSKESPF PRKEYFEFIT KTLGKDNYAS 660
  661 RIKQFKKDSY FSKVDMNEDS ILTPELDETG LPKVYFSTYF IQLFNENIYR IRTALSHDPD 720
  721 EEPINKISFE EVEKLQRQCT KLKGEITSLQ TETESTHENL TEKLIALTNE HKELDEKYQI 780
  781 LNSSHSSLKE NFSILETELK NVRDSLDEMT QLRDVLETKD KENQTALLEY KSTIHKQEDS 840
  841 IKTLEKGLET ILSQKKKAED GINKMGKDLF ALSREMQAVE ENCKNLQKEK DKSNVNHQKE 900
  901 TKSLKEDIAA KITEIKAINE NLEEMKIQCN NLSKEKEHIS KELVEYKSRF QSHDNLVAKL 960
  961 TEKLKSLANN YKDMQAENES LIKAVEESKN ESSIQLSNLQ NKIDSMSQEK ENFQIERGSI1020
 1021 EKNIEQLKKT ISDLEQTKEE IISKSDSSKD EYESQISLLK EKLETATTAN DENVNKISEL1080
 1081 TKTREELEAE LAAYKNLKNE LETKLETSEK ALKEVKENEE HLKEEKIQLE KEATETKQQL1140
 1141 NSLRANLESL EKEHEDLAAQ LKKYEEQIAN KERQYNEEIS QLNDEITSTQ QENESIKKKN1200
 1201 DELEGEVKAM KSTSEEQSNL KKSEIDALNL QIKELKKKNE TNEASLLESI KSVESETVKI1260
 1261 KELQDECNFK EKEVSELEDK LKASEDKNSK YLELQKESEK IKEELDAKTT ELKIQLEKIT1320
 1321 NLSKAKEKSE SELSRLKKTS SEERKNAEEQ LEKLKNEIQI KNQAFEKERK LLNEGSSTIT1380
 1381 QEYSEKINTL EDELIRLQNE NELKAKEIDN TRSELEKVSL SNDELLEEKQ NTIKSLQDEI1440
 1441 LSYKDKITRN DEKLLSIERD NKRDLESLKE QLRAAQESKA KVEEGLKKLE EESSKEKAEL1500
 1501 EKSKEMMKKL ESTIESNETE LKSSMETIRK SDEKLEQSKK SAEEDIKNLQ HEKSDLISRI1560
 1561 NESEKDIEEL KSKLRIEAKS GSELETVKQE LNNAQEKIRI NAEENTVLKS KLEDIERELK1620
 1621 DKQAEIKSNQ EEKELLTSRL KELEQELDST QQKAQKSEEE RRAEVRKFQV EKSQLDEKAM1680
 1681 LLETKYNDLV NKEQAWKRDE DTVKKTTDSQ RQEIEKLAKE LDNLKAENSK LKEANEDRSE1740
 1741 IDDLMLLVTD LDEKNAKYRS KLKDLGVEIS SDEEDDEEDD EEDEEEGQVA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GLN4 USO1
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 CLU1 CRN1 DYN1 ECM29 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MEC1 MIP6 MIS1 MRPL23 MSB1 NAB3 NAB6 NIP1 NMD5 NRD1 PFK1 POL1 POL12 PRI1 PRI2 PRO1 PRT1 PSD2 PSE1 PSH1 RFC1 RFC3 RFC4 RFC5 ROM2 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 SEN54 SUI3 SUP35 SUP45 TAO3 TEL1 TSC11 USO1 UTP20 VAC14 VPS5 VTH2 YFR006W YJL017W YPR077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data USO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] ORFEUS 14.86 beta-Catenin
    2 View Details [187..288] ORFEUS 14.86 beta-Catenin
    3 View Details [289..372] ORFEUS 14.86 beta-Catenin
    4 View Details [373..628] PSI-BLAST 137.201249 Heavy meromyosin subfragment
    5 View Details [629..1013] PSI-BLAST 137.201249 Heavy meromyosin subfragment
    6 View Details [1014..1124] PSI-BLAST 9.09691 Tropomyosin
    7 View Details [1125..1207] PSI-BLAST 9.09691 Tropomyosin
    8 View Details [1208..1269] PSI-BLAST 9.09691 Tropomyosin
    9 View Details [1270..1349] PSI-BLAST 9.09691 Tropomyosin
    10 View Details [1350..1474] ORFEUS 11.85 Heavy meromyosin subfragment
    11 View Details [1475..1790] ORFEUS 11.85 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.54751411727402 bayes_pls_golite062009
  • clathrin binding
    		•  3.06219301699422 bayes_pls_golite062009
  • binding
    		•  2.38363524631144 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87445049214426 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.29496918547173 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.80477645195818 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0128158555898987 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.00672548245940896 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle