YRC Public Data Repository - Protein Structure Prediction

Protein:	USO1
Organism:	Saccharomyces cerevisiae
Length:	1790 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for USO1.

Description	E-value	Query Range	Subject Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1	0.0	[390..1743]	[636..1927]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1	0.0	[390..1743]	[639..1930]
gi\|9800488, gi\|1... - gi\|9800488\|gb\|AAF99315.1\|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi\|165973976\|...	0.0	[390..1743]	[639..1930]
gi\|179508, gi\|10... - sp\|P12883\|MYH7_HUMAN Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta), gi\|4557773\|ref\|NP...	0.0	[388..1743]	[632..1925]
MYH7_MOUSE - Myosin-7 OS=Mus musculus GN=Myh7 PE=1 SV=1	0.0	[391..1743]	[635..1925]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[390..1743]	[636..1927]

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Predicted Domain #1

Region A:
Residues: [1-186]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIIQGLIQQ PKIQSVDETI PTLCDRVENS TLISDRRSAV LGLKAFSRQY RESVIASGLK  60
   61 PLLNTLKRDY MDEDSVKAIL ETILILFIRG DGHDDLTRGW ISQQSRLQNG KYPSPLVMKQ 120
  121 EKEQVDQFSL WIADALTQSE DLIHLLVEFW EIDNFHIRLY TIQLLEAVMA TRPLKARSAL 180
  181 ISLPTS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.86
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	3.54751411727402	bayes_pls_golite062009
clathrin binding	3.06219301699422	bayes_pls_golite062009
binding	2.38363524631144	bayes_pls_golite062009
transporter activity	2.3766833486706	bayes_pls_golite062009
substrate-specific transporter activity	1.87445049214426	bayes_pls_golite062009
protein binding	1.81870125631028	bayes_pls_golite062009
protein transmembrane transporter activity	1.29496918547173	bayes_pls_golite062009
transmembrane transporter activity	1.2724388835449	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.80477645195818	bayes_pls_golite062009
active transmembrane transporter activity	0.260663498540354	bayes_pls_golite062009
primary active transmembrane transporter activity	0.0128158555898987	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.00672548245940896	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [187-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISTMVSLLDD MHEPIRDEAI LLLMAVVNDS PHVQKLVAFE NIFERLFSII EEEGGLRGSL  60
   61 VVNDCLSLIN NILKYNTSNQ TLFLETGNLP KLAHLLSEPI SQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.86
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [289-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEVFFWNDQR IVNINTALDI VSLTVEPGNT VTTKHQNALL DSSVLMVVLR LAFFHNIPKK  60
   61 VRPVALLTAA NMVRSNEHAQ LEFS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.86
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [373-628]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIDVPYFDPS LPVNSTANGG PIKLIPVVSI LINWMLYANS VHTFDTRVAC SRLLKAYFMD  60
   61 NFDLQRDFLL KQVQLCNNST NNVGDNAKEN GGSNKSDKES DSDKDTDGKD GTEYEGSFKA 120
  121 NLFEVLLNYD AELNLNPFKL FFTTDIFMFF FQQDHKYSEE LREITRNVTT GNDLEDEEPL 180
  181 KAIQTISELL TTSLTAADIR IPISYLTFLI YWLFGDFKAT NDFLSDKSVI KSLLSFSYQI 240
  241 QDEDVTIKCL VTMLLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	137.201249
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [629-1013]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAYEFSSKES PFPRKEYFEF ITKTLGKDNY ASRIKQFKKD SYFSKVDMNE DSILTPELDE  60
   61 TGLPKVYFST YFIQLFNENI YRIRTALSHD PDEEPINKIS FEEVEKLQRQ CTKLKGEITS 120
  121 LQTETESTHE NLTEKLIALT NEHKELDEKY QILNSSHSSL KENFSILETE LKNVRDSLDE 180
  181 MTQLRDVLET KDKENQTALL EYKSTIHKQE DSIKTLEKGL ETILSQKKKA EDGINKMGKD 240
  241 LFALSREMQA VEENCKNLQK EKDKSNVNHQ KETKSLKEDI AAKITEIKAI NENLEEMKIQ 300
  301 CNNLSKEKEH ISKELVEYKS RFQSHDNLVA KLTEKLKSLA NNYKDMQAEN ESLIKAVEES 360
  361 KNESSIQLSN LQNKIDSMSQ EKENF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	137.201249
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [1014-1124]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIERGSIEKN IEQLKKTISD LEQTKEEIIS KSDSSKDEYE SQISLLKEKL ETATTANDEN  60
   61 VNKISELTKT REELEAELAA YKNLKNELET KLETSEKALK EVKENEEHLK E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.09691
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [1125-1207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKIQLEKEAT ETKQQLNSLR ANLESLEKEH EDLAAQLKKY EEQIANKERQ YNEEISQLND  60
   61 EITSTQQENE SIKKKNDELE GEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.09691
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [1208-1269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAMKSTSEEQ SNLKKSEIDA LNLQIKELKK KNETNEASLL ESIKSVESET VKIKELQDEC  60
   61 NF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.09691
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1270-1349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEKEVSELED KLKASEDKNS KYLELQKESE KIKEELDAKT TELKIQLEKI TNLSKAKEKS  60
   61 ESELSRLKKT SSEERKNAEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.09691
Match:	2tmaA_
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [1350-1474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLEKLKNEIQ IKNQAFEKER KLLNEGSSTI TQEYSEKINT LEDELIRLQN ENELKAKEID  60
   61 NTRSELEKVS LSNDELLEEK QNTIKSLQDE ILSYKDKITR NDEKLLSIER DNKRDLESLK 120
  121 EQLRA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.85
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #11

Region A:
Residues: [1475-1790]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQESKAKVEE GLKKLEEESS KEKAELEKSK EMMKKLESTI ESNETELKSS METIRKSDEK  60
   61 LEQSKKSAEE DIKNLQHEKS DLISRINESE KDIEELKSKL RIEAKSGSEL ETVKQELNNA 120
  121 QEKIRINAEE NTVLKSKLED IERELKDKQA EIKSNQEEKE LLTSRLKELE QELDSTQQKA 180
  181 QKSEEERRAE VRKFQVEKSQ LDEKAMLLET KYNDLVNKEQ AWKRDEDTVK KTTDSQRQEI 240
  241 EKLAKELDNL KAENSKLKEA NEDRSEIDDL MLLVTDLDEK NAKYRSKLKD LGVEISSDEE 300
  301 DDEEDDEEDE EEGQVA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.85
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: