YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	36 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ACT1	cellular bud neck contractile ring NuA4 histone acetyltransferase complex Swr1 complex Ino80 complex actin filament actin cortical patch histone acetyltransferase complex	DNA repair contractile ring contraction involved in cell cycle cytokinesis vesicle transport along actin filament response to osmotic stress cellular cell wall organization cytokinesis endocytosis exocytosis protein secretion chronological cell aging regulation of transcription from RNA polymerase II promoter mitochondrion inheritance ascospore formation vacuole inheritance establishment of mitotic spindle orientation response to oxidative stress budding cell isotropic bud growth histone acetylation actin filament reorganization involved in cell cycle	structural constituent of cytoskeleton
AIM31	mitochondrion	biological_process	molecular_function
CFT1	mRNA cleavage and polyadenylation specificity factor complex mitochondrion mRNA cleavage factor complex	termination of RNA polymerase II transcription mRNA polyadenylation mRNA cleavage	RNA binding
CFT2	mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex	mRNA polyadenylation mRNA cleavage	RNA binding
CKA1	protein kinase CK2 complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle flocculation via cell wall protein-carbohydrate interaction protein amino acid phosphorylation response to DNA damage stimulus regulation of transcription from RNA polymerase III promoter regulation of transcription from RNA polymerase I promoter cellular ion homeostasis	protein kinase CK2 activity
CLP1	mRNA cleavage factor complex	mRNA 3'-end processing mRNA polyadenylation mRNA cleavage	RNA binding
ENO2	soluble fraction mitochondrion phosphopyruvate hydratase complex vacuole	gluconeogenesis regulation of vacuole fusion, non-autophagic glycolysis	phosphopyruvate hydratase activity
FIP1	mRNA cleavage and polyadenylation specificity factor complex	mRNA polyadenylation mRNA cleavage	RNA binding protein binding
GLC7	protein phosphatase type 1 complex mRNA cleavage and polyadenylation specificity factor complex cellular bud neck spindle pole body nuclear outer membrane nucleolus mating projection base	mitotic cell cycle spindle assembly checkpoint cell morphogenesis during vegetative growth protein amino acid dephosphorylation chromosome segregation cell budding cellular ion homeostasis meiosis regulation of carbohydrate metabolic process ascospore formation response to heat termination of RNA polymerase II transcription, poly(A)-coupled glycogen metabolic process termination of RNA polymerase II transcription, poly(A)-independent histone dephosphorylation	protein serine/threonine phosphatase activity phosphoprotein phosphatase activity RNA binding metal ion binding hydrolase activity
HHF1, HHF2	nucleus nucleoplasm part nuclear nucleosome chromosome replication fork protection complex chromatin remodeling complex nucleosome histone acetyltransferase complex nucleoplasm	histone H3-K79 methylation DNA repair negative regulation of transcription chromatin assembly or disassembly positive regulation of transcription nucleosome assembly	DNA binding
HTA1	nuclear nucleosome	DNA repair chromatin assembly or disassembly	DNA binding
MPE1	mRNA cleavage and polyadenylation specificity factor complex	mRNA polyadenylation mRNA cleavage	RNA binding
PAP1	mRNA cleavage and polyadenylation specificity factor complex nucleoplasm	mRNA export from nucleus mRNA polyadenylation	polynucleotide adenylyltransferase activity
PCF11	mRNA cleavage factor complex	termination of RNA polymerase II transcription mRNA polyadenylation mRNA cleavage	protein binding
PFK1	6-phosphofructokinase complex cytoplasm mitochondrion	glycolysis	6-phosphofructokinase activity
PFS2	mRNA cleavage and polyadenylation specificity factor complex	mRNA polyadenylation mRNA cleavage	RNA binding
PTA1	mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex	termination of RNA polymerase II transcription, poly(A)-coupled tRNA processing termination of RNA polymerase II transcription, poly(A)-independent mRNA polyadenylation mRNA cleavage	RNA binding
PTI1	nucleus mRNA cleavage and polyadenylation specificity factor complex	termination of RNA polymerase II transcription, poly(A)-coupled termination of RNA polymerase II transcription, poly(A)-independent mRNA polyadenylation mRNA cleavage snoRNA 3'-end processing	RNA binding
REF2	nucleus mRNA cleavage and polyadenylation specificity factor complex	termination of RNA polymerase II transcription, poly(A)-coupled termination of RNA polymerase II transcription, poly(A)-independent telomere maintenance mRNA processing snoRNA 3'-end processing	DNA binding RNA binding
RNA14	nucleus mitochondrion mRNA cleavage factor complex	mRNA polyadenylation mRNA cleavage	RNA binding protein heterodimerization activity
RNA15	mRNA cleavage factor complex	mRNA polyadenylation mRNA cleavage	RNA binding protein heterodimerization activity
RSA3	nucleolus preribosome, large subunit precursor	ribosomal large subunit assembly	molecular_function
SEC13	cytoplasm extrinsic to membrane COPII vesicle coat nuclear pore	ER to Golgi vesicle-mediated transport membrane budding nuclear pore organization ER-associated protein catabolic process	structural molecule activity
SEC31	COPII vesicle coat	ER to Golgi vesicle-mediated transport	structural molecule activity
SSA3	cytosol	SRP-dependent cotranslational protein targeting to membrane, translocation protein folding response to stress	ATPase activity unfolded protein binding
SSU72	nucleus mRNA cleavage and polyadenylation specificity factor complex nuclear outer membrane	termination of RNA polymerase II transcription, poly(A)-coupled termination of RNA polymerase II transcription, poly(A)-independent snoRNA transcription termination of RNA polymerase II transcription transcription initiation from RNA polymerase II promoter	phosphoprotein phosphatase activity RNA binding protein tyrosine phosphatase activity phosphoric ester hydrolase activity
SYC1	nucleus mRNA cleavage and polyadenylation specificity factor complex	termination of RNA polymerase II transcription, poly(A)-coupled termination of RNA polymerase II transcription, poly(A)-independent	RNA binding
TAF6	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
TIF4632	eukaryotic translation initiation factor 4F complex ribosome	translational initiation	translation initiation factor activity
TYE7	nucleus	transcription regulation of transcription involved in G1/S-phase of mitotic cell cycle positive regulation of glycolysis	transcription factor activity
VID24	cytoplasmic membrane-bounded vesicle extrinsic to membrane	vesicle-mediated transport negative regulation of gluconeogenesis	molecular_function
VMR1	mitochondrion integral to membrane ribosome	transport	ATPase activity, coupled to transmembrane movement of substances
VPS53	GARP complex cytoplasm Golgi apparatus	retrograde transport, endosome to Golgi Golgi to vacuole transport	protein binding
YCL046W
YSH1	mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex	mRNA polyadenylation mRNA cleavage	RNA binding endoribonuclease activity
YTH1	mRNA cleavage and polyadenylation specificity factor complex	mRNA polyadenylation mRNA cleavage	RNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mRNA cleavage factor complex	4.7093E-41	36	20	18	6292
mRNA cleavage and polyadenylation specificity factor complex	3.2937E-32	36	15	14	6292
nucleoplasm part	3.5393E-21	36	245	21	6292
nucleoplasm	1.7334E-20	36	264	21	6292
nuclear lumen	6.5692E-17	36	453	22	6292
protein complex	8.0462E-15	36	1137	28	6292
macromolecular complex	5.2675E-14	36	1635	31	6292
organelle lumen	1.8876E-13	36	660	22	6292
intracellular organelle lumen	1.8876E-13	36	660	22	6292
membrane-enclosed lumen	6.3948E-13	36	700	22	6292
nuclear part	8.2728E-11	36	1103	24	6292
nucleus	5.6238E-6	36	2041	25	6292
intracellular organelle part	1.1779E-5	36	2282	26	6292
organelle part	1.1779E-5	36	2282	26	6292
membrane-bounded organelle	1.3587E-4	36	3771	32	6292
intracellular membrane-bounded organelle	1.3587E-4	36	3771	32	6292
intracellular organelle	2.0501E-4	36	4070	33	6292
organelle	2.0643E-4	36	4071	33	6292
COPII vesicle coat	8.7221E-4	36	8	2	6292
ER to Golgi transport vesicle membrane	8.7221E-4	36	8	2	6292
cytoplasmic vesicle part	1.3649E-3	36	39	3	6292
intracellular part	1.732E-3	36	4938	35	6292
histone acetyltransferase complex	1.9395E-3	36	44	3	6292
nuclear nucleosome	2.0265E-3	36	12	2	6292
nucleosome	2.0265E-3	36	12	2	6292
intracellular	2.1969E-3	36	4975	35	6292
membrane-bounded vesicle	3.0638E-3	36	107	4	6292
cytoplasmic vesicle	3.0638E-3	36	107	4	6292
cytoplasmic membrane-bounded vesicle	3.0638E-3	36	107	4	6292
transport vesicle membrane	3.1894E-3	36	15	2	6292
vesicle	3.386E-3	36	110	4	6292
nuclear chromatin	8.1316E-3	36	73	3	6292
chromatin	9.4157E-3	36	77	3	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mRNA polyadenylation	2.52E-29	36	19	14	6292
RNA polyadenylation	2.0455E-26	36	26	14	6292
mRNA 3'-end processing	5.5251E-25	36	31	14	6292
RNA 3'-end processing	6.9969E-25	36	42	15	6292
mRNA cleavage	3.0022E-24	36	25	13	6292
nucleic acid phosphodiester bond hydrolysis	5.4682E-20	36	46	13	6292
mRNA processing	1.4857E-15	36	156	15	6292
termination of RNA polymerase II transcription	3.6097E-14	36	19	8	6292
transcription termination	9.6415E-14	36	21	8	6292
mRNA metabolic process	1.599E-13	36	213	15	6292
termination of RNA polymerase II transcription, poly(A)-independent	1.8798E-12	36	9	6	6292
termination of RNA polymerase II transcription, poly(A)-coupled	4.6803E-12	36	10	6	6292
cellular protein complex disassembly	2.7137E-11	36	39	8	6292
protein complex disassembly	2.7137E-11	36	39	8	6292
macromolecular complex disassembly	3.3786E-11	36	40	8	6292
cellular macromolecular complex disassembly	3.3786E-11	36	40	8	6292
cellular component disassembly	7.6633E-11	36	44	8	6292
RNA metabolic process	3.426E-10	36	954	22	6292
RNA processing	6.8473E-10	36	380	15	6292
gene expression	2.1598E-9	36	1283	24	6292
nucleic acid metabolic process	1.7078E-8	36	1415	24	6292
cellular macromolecular complex subunit organization	1.1195E-7	36	259	11	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.3902E-7	36	1566	24	6292
macromolecular complex subunit organization	3.359E-7	36	357	12	6292
transcription from RNA polymerase II promoter	1.4955E-6	36	335	11	6292
cellular nitrogen compound metabolic process	1.6308E-6	36	1770	24	6292
nitrogen compound metabolic process	2.0578E-6	36	1791	24	6292
cellular macromolecule metabolic process	2.4523E-6	36	2285	27	6292
primary metabolic process	4.2049E-6	36	2896	30	6292
macromolecule metabolic process	4.5329E-6	36	2349	27	6292
transcription	5.5169E-6	36	552	13	6292
transcription, DNA-dependent	1.2604E-5	36	503	12	6292
cellular metabolic process	1.3452E-5	36	3033	30	6292
RNA biosynthetic process	1.3946E-5	36	508	12	6292
metabolic process	3.6249E-5	36	3157	30	6292
snoRNA metabolic process	1.3235E-4	36	18	3	6292
snoRNA 3'-end processing	3.1489E-4	36	5	2	6292
glucose metabolic process	3.4971E-4	36	109	5	6292
glycolysis	3.6291E-4	36	25	3	6292
hexose metabolic process	6.3355E-4	36	124	5	6292
snoRNA processing	6.5652E-4	36	7	2	6292
monosaccharide metabolic process	9.3233E-4	36	135	5	6292
regulation of carbohydrate metabolic process	1.079E-3	36	36	3	6292
covalent chromatin modification	1.4955E-3	36	88	4	6292
histone modification	1.4955E-3	36	88	4	6292
glucose catabolic process	1.9395E-3	36	44	3	6292
ncRNA 3'-end processing	2.0265E-3	36	12	2	6292
cellular process	2.0511E-3	36	4426	33	6292
hexose catabolic process	2.6458E-3	36	49	3	6292
monosaccharide catabolic process	3.4929E-3	36	54	3	6292
cellular macromolecule biosynthetic process	3.9906E-3	36	1187	14	6292
macromolecule biosynthetic process	4.055E-3	36	1189	14	6292
alcohol catabolic process	4.0723E-3	36	57	3	6292
chromatin organization	5.5546E-3	36	203	5	6292
histone H3-K79 methylation	5.7216E-3	36	1	1	6292
snoRNA transcription	5.7216E-3	36	1	1	6292
alcohol metabolic process	7.7724E-3	36	220	5	6292
cellular carbohydrate catabolic process	7.8279E-3	36	72	3	6292
cellular biosynthetic process	8.0893E-3	36	1567	16	6292
carbohydrate catabolic process	8.7597E-3	36	75	3	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA binding	3.2556E-11	36	367	16	6292
nucleic acid binding	3.3783E-11	36	666	20	6292
binding	1.9094E-8	36	1294	23	6292
protein heterodimerization activity	1.8962E-4	36	4	2	6292
protein dimerization activity	4.7064E-4	36	6	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis