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Protein Overview: FPR1

General Information:
Name(s) found: FPR1 / YNL135C [SGD]
Description(s) found:
Found 39 descriptions.
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  • Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 114 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: chromatin organization [IGILink to PubMed article]
    homoserine metabolic process [IGILink to PubMed article]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVIEGNVK IDRISPGDGA TFPKTGDLVT IHYTGTLENG QKFDSSVDRG SPFQCNIGVG  60
   61 QVIKGWDVGI PKLSVGEKAR LTIPGPYAYG PRGFPGLIPP NSTLVFDVEL LKVN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FAP1 FPR1 HOM3
    View Details Krogan NJ, et al. (2006) FAP1 FPR1 MRP2 YIL161W
    View Details Gavin AC, et al. (2002) CCL1 DCS2 FAP1 FPR1 KAP95 KIN28 MRPS28 SPT7 SSL1 TFA1 TFB1 TFB3 TFB4 TIF6
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ADE3 AFR1 AHP1 ALA1 ARC1 ARF1 ASR1 ATP3 CAR2 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FAP1 FPR1 FRS2 GDI1 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 HOM3 HSH49 KRS1 LRO1 LSP1 MET6 MLP2 NTF2 OLA1 OYE2 PFK1 PFK2 PIL1 PRM2 RNR2 RPB11 RPB3 RPB9 RPO21 RSN1 SAC6 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 SSZ1 TEF4 THS1 TIF1, TIF2 TMA19 TRP5 TSA2 UBA1 URA1 VMA4 VMA5 WTM1 YDR131C YDR341C YMR315W YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FPR1 YMR087W 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FPR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] PSI-BLAST 606.68867 Calcineurin (FKBP12.6)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.85589011277711 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.780499202755666 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • activin binding
    		•  0.33489895389042 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle