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Protein Overview: TSC11

General Information:
Name(s) found: TSC11 / YER093C [SGD]
Description(s) found:
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  • gi|731493|sp|P40061.1|TSC11_YEAST RecName: Full=Target of rapamycin complex 2 subunit TSC11; Short=TORC2 subunit TSC11; AltName: Full=Adheres voraciously to TOR2 protein 3; AltName: Full=Temperature-sensitive CSG2 suppressor protein 11 [NCBI NR]
  • gi|6320939|ref|NP_011018.1| Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a R [NCBI NR]
  • gi|603331|gb|AAB64648.1| Yer093cp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50596 hypothetical protein YER093c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (P40061) Uncharacterized protein YER093C [Swiss-Prot]
  • Target of rapamycin complex 2 subunit TSC11 OS=Saccharomyces cerevisiae GN=TSC11 PE=1 SV=1 [Swiss-Prot]
  • TSC11 Lipid biosynthesis, binding of TOR [mips]
  • Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain [SGD]
  • YER093C, Chr V from 343316-347608, reverse complement [yeast_orfs2]
  • Chr V from 343316-347608, reverse complement [yeastorf3.fasta]
  • Chr V from 347608-343316, reverse complement [yeastorf5.fasta]
  • (P40061) Hypothetical 164.4 kDa protein in MET6-PUP3 intergenic region [4932.FASTACCERV.txt]
  • TSC11 SGDID:S0000895, Chr V from 347608-343316, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Binding Protein of TOR; Protein required for cell viability [Saccharomyces cerevisiae]gi|731493|sp|P40061|YES3_YEAST Hypothetical 164.4 kDa protein in MET6-PUP3 intergenic regiongi|1077685|pir||S50596 hypothetical protein YER093c - yeast (Saccharomyces [nrdb_11152004_Chlamydomonas]
  • TSC11 SGDID:S000000895, Chr V from 347608-343316, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall int [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; Tsc11p [Sacch [nr-271106-contam.fasta]
  • Uncharacterized protein YER093C [nr-271106-contam.fasta]
  • Yer093cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TSC11 SGDID:S000000895, Chr V from 347608-343316, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Target of rapamycin complex 2 subunit TSC11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSC11 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TSC11 SGDID:S000000895, Chr V from 347612-343320, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" [yeast-030211-contam.fasta]
  • TSC11 SGDID:S000000895, Chr V from 347612-343320, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" [20141208_orf_trans.fasta]
  • YER093C SGDID:S000000895, Chr V from 347612-343320, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1430 amino acids

    Gene Ontology:
    Cellular Component: TORC2 complex [IPILink to PubMed article]
    Biological Process: regulation of cell growth [IPILink to PubMed article]
    cellular cell wall organization [IGILink to PubMed article][IMPLink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IMPLink to PubMed article][IPILink to PubMed article]
    sphingolipid biosynthetic process [IGILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPHSAKQS SPLSSRRRSV TNTTPLLTPR HSRDNSSTQI SSAKNITSSS PSTITNESSK  60
   61 RNKQNLVLST SFISTKRLEN SAPSPTSPLM ARRTRSTMTK ALLNLKAEIN NQYQELARLR 120
  121 KKKDDIEHLR DSTISDIYSG SYSTNHLQKH SMRIRANTQL REIDNSIKRV EKHIFDLKQQ 180
  181 FDKKRQRSLT TSSSIKADVG SIRNDDGQNN DSEELGDHDS LTDQVTLDDE YLTTPTSGTE 240
  241 RNSQQNLNRN STVNSRNNEN HSTLSIPDLD GSNKVNLTGD TEKDLGDLEN ENQIFTSTTT 300
  301 EAATWLVSDY MQSFQEKNVN PDFIAQKANG LVTLLKEHSE IRKDLVLTSF MSSIQNLLLN 360
  361 GNKLIAASAY RVCRYLINSS IFIDELLELR LDAFIIISLA KDNSFQIERE QALKMVRRFI 420
  421 EYNNGVTQGI MQAIISCVEK PEDSLRHMAL ETLLELCFVA PEMVKECRGM RVIEGFLQDY 480
  481 TSFSLASVIL DTILQLMATH KTRQHFLEDF NVSVLTTVFS DTNTKSNVNV EKMQNASTLI 540
  541 SITLNSYNGF MLFSNNNFKP LKQLVSFFQI PICAQYLIDI FLDVLKIKPL PYKPRGRHSH 600
  601 SFKPIPSQYY KECMSVNQRL ALIVLILENS EFVPHLLELL NEEDRDDHLV AKGRYLLTEY 660
  661 FNLRMNLVDK KYTSVSKPIY KENFTYVNET FQFKKIAYKM NRNRNTIGMS GIDYAQNIKS 720
  721 FSKNIKENTL LREVDDFRFR RMVYDSKVLQ TKDFTRWNWN IINELLEGPL LNKKQLEELV 780
  781 KSTKFIRRLL VFYRPLRLRF SNVNKGAKLS QKYVQVGCQF FKTLTATPEG MKILMDDTKI 840
  841 IPQLASLMFR AMEGNISGNI FNKNKLREKI IFGYFKFIGI LTQSKNGVHI LTRWNFFTVI 900
  901 YKMFQFESKL GLEFLLLTIP ELDLKYSSHC RVIIGKALVV ANEKVRIEAT KHIGDKLKEL 960
  961 LSTKESDLKL KANKVKLQQF KMEMLTRQLY DLSPSVVAVA DQALYECIVA GNGSEELGTS1020
 1021 FRMFLNQMVF IRSPILFELL SRPYGFQLLN EINFVKEERD SWLSKKNIEY VHIVEEFLKK1080
 1081 NESINAKSLT FQQKSRLPLH FYESLTKTED GILLLSQTGD LVTFMNVIKK YVNGNNMATV1140
 1141 ENAKEILDLK AALWCVGFIG STELGIGLLD NYSLVEDIIE VAYNASVTSV RFTAFYVLGL1200
 1201 ISMTREGCEI LDEMGWNCCV SVQDEPIGIA LPNRLDRFLS YNEHKWSAFG EYSDEMIVFN1260
 1261 KSDGDLIEKC LPIEFDLDKL LKEKDTAENP LNEKIITNKY DNDITSQTIT VSGENSSLFA1320
 1321 NEGLSSPYVT QYRNDDDSIE SKVLHIVSQL GNHILSNHAV KEITEINNKY GPRLFENEKM1380
 1381 FFKVFNMMSK YRFKPHVRKF LCGLFINNRA LENVIRHDNK RDKRPANFTR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
    View Details Ho Y, et al. (2002) AVO1 BEM3 CCT2 CYS4 DIG1 DIG2 GUS1 KSS1 NPA3 PIM1 RPA135 RPN6 RVB1 STE11 STE12 TEC1 TSC11
    View Details Qiu et al. (2008) AVO1 AVO2 BIT61 LST8 SLM1 SLM2 TOR2 TSC11

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT21 TSC11 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..52] PSI-BLAST 44.09691 Heavy meromyosin subfragment
    2 View Details [53..72]
    [152..180]    		 PSI-BLAST 5.154902 Colicin Ia; Colicin Ia, N-terminal domain
    3 View Details [73..151]
    [181..211]    		 PSI-BLAST 5.154902 Colicin Ia; Colicin Ia, N-terminal domain
    4 View Details [212..467] PSI-BLAST 5.154902 Colicin Ia; Colicin Ia, N-terminal domain
    5 View Details [468..588] ORFEUS 7.18 Son of sevenless protein homolog 1 (sos-1)
    6 View Details [589..906] deduced N/A No confident structure predictions are available.
    7 View Details [907..1282] MSA 1.007917 View MSA. No confident structure predictions are available.
    8 View Details [1283..1430] deduced N/A No confident structure predictions are available.
    9 View Details [1225..1299] deduced N/A No confident structure predictions are available.
    10 View Details [1300..1430] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle