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View Structure Prediction Details

Protein: TSC11
Organism: Saccharomyces cerevisiae
Length: 1430 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TSC11.

Description E-value Query
Range
Subject
Range
TSC11_YEAST - Target of rapamycin complex 2 subunit TSC11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
TSC11 - Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates...
0.0 [1..1430] [1..1430]
RICTR_SCHPO - Target of rapamycin complex 2 subunit ste20 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
ste20 - sterility protein Ste20
0.0 [108..1429] [14..1306]
gi|60470688, gi|... - gi|66817522|ref|XP_642614.1| cytosolic regulator of adenylyl cyclase [Dictyostelium discoideum AX4],...
PIAA_DICDI - Protein pianissimo A OS=Dictyostelium discoideum GN=piaA PE=1 SV=1
0.0 [288..1405] [32..1134]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [288..1405] [32..1134]
gi|18605769 - gi|18605769|gb|AAH22906.1| 4921505C17Rik protein [Mus musculus]
0.0 [411..1156] [1..786]
gi|3668187 - gi|3668187|dbj|BAA33452.1| myosin heavy chain [Theragra chalcogramma]
4.0E-69 [2..416] [878..1283]

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Predicted Domain #1
Region A:
Residues: [1-52]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPHSAKQS SPLSSRRRSV TNTTPLLTPR HSRDNSSTQI SSAKNITSSS PS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.09691
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [53-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TITNESSKRN KQNLVLSTSF 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [152-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIRANTQLR EIDNSIKRVE KHIFDLKQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [73-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISTKRLENSA PSPTSPLMAR RTRSTMTKAL LNLKAEINNQ YQELARLRKK KDDIEHLRDS  60
   61 TISDIYSGSY STNHLQKHS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [181-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDKKRQRSLT TSSSIKADVG SIRNDDGQNN D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [212-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEELGDHDSL TDQVTLDDEY LTTPTSGTER NSQQNLNRNS TVNSRNNENH STLSIPDLDG  60
   61 SNKVNLTGDT EKDLGDLENE NQIFTSTTTE AATWLVSDYM QSFQEKNVNP DFIAQKANGL 120
  121 VTLLKEHSEI RKDLVLTSFM SSIQNLLLNG NKLIAASAYR VCRYLINSSI FIDELLELRL 180
  181 DAFIIISLAK DNSFQIEREQ ALKMVRRFIE YNNGVTQGIM QAIISCVEKP EDSLRHMALE 240
  241 TLLELCFVAP EMVKEC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [468-588]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGMRVIEGFL QDYTSFSLAS VILDTILQLM ATHKTRQHFL EDFNVSVLTT VFSDTNTKSN  60
   61 VNVEKMQNAS TLISITLNSY NGFMLFSNNN FKPLKQLVSF FQIPICAQYL IDIFLDVLKI 120
  121 K

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.18
Match: 1bkdS
Description: Son of sevenless protein homolog 1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [589-906]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLPYKPRGRH SHSFKPIPSQ YYKECMSVNQ RLALIVLILE NSEFVPHLLE LLNEEDRDDH  60
   61 LVAKGRYLLT EYFNLRMNLV DKKYTSVSKP IYKENFTYVN ETFQFKKIAY KMNRNRNTIG 120
  121 MSGIDYAQNI KSFSKNIKEN TLLREVDDFR FRRMVYDSKV LQTKDFTRWN WNIINELLEG 180
  181 PLLNKKQLEE LVKSTKFIRR LLVFYRPLRL RFSNVNKGAK LSQKYVQVGC QFFKTLTATP 240
  241 EGMKILMDDT KIIPQLASLM FRAMEGNISG NIFNKNKLRE KIIFGYFKFI GILTQSKNGV 300
  301 HILTRWNFFT VIYKMFQF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [907-1282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESKLGLEFLL LTIPELDLKY SSHCRVIIGK ALVVANEKVR IEATKHIGDK LKELLSTKES  60
   61 DLKLKANKVK LQQFKMEMLT RQLYDLSPSV VAVADQALYE CIVAGNGSEE LGTSFRMFLN 120
  121 QMVFIRSPIL FELLSRPYGF QLLNEINFVK EERDSWLSKK NIEYVHIVEE FLKKNESINA 180
  181 KSLTFQQKSR LPLHFYESLT KTEDGILLLS QTGDLVTFMN VIKKYVNGNN MATVENAKEI 240
  241 LDLKAALWCV GFIGSTELGI GLLDNYSLVE DIIEVAYNAS VTSVRFTAFY VLGLISMTRE 300
  301 GCEILDEMGW NCCVSVQDEP IGIALPNRLD RFLSYNEHKW SAFGEYSDEM IVFNKSDGDL 360
  361 IEKCLPIEFD LDKLLK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1283-1430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKDTAENPLN EKIITNKYDN DITSQTITVS GENSSLFANE GLSSPYVTQY RNDDDSIESK  60
   61 VLHIVSQLGN HILSNHAVKE ITEINNKYGP RLFENEKMFF KVFNMMSKYR FKPHVRKFLC 120
  121 GLFINNRALE NVIRHDNKRD KRPANFTR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1225-1299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPIGIALPNR LDRFLSYNEH KWSAFGEYSD EMIVFNKSDG DLIEKCLPIE FDLDKLLKEK  60
   61 DTAENPLNEK IITNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1300-1430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDNDITSQTI TVSGENSSLF ANEGLSSPYV TQYRNDDDSI ESKVLHIVSQ LGNHILSNHA  60
   61 VKEITEINNK YGPRLFENEK MFFKVFNMMS KYRFKPHVRK FLCGLFINNR ALENVIRHDN 120
  121 KRDKRPANFT R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle