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Protein Overview: PRO1

General Information:
Name(s) found: PRO1 / YDR300C [SGD]
Description(s) found:
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  • gi|849219|gb|AAB64736.1| Pro1p: Glutamate 5-kinase (Swiss Prot. accession number P32264) [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6320506|ref|NP_010586.1| Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis; Pro1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S61186 glutamate 5-kinase (EC 2.7.2.11) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1709785|sp|P32264.2|PROB_YEAST RecName: Full=Glutamate 5-kinase; Short=GK; AltName: Full=Gamma-glutamyl kinase [NCBI NR]
  • Glutamate 5-kinase OS=Saccharomyces cerevisiae GN=PRO1 PE=1 SV=2 [Swiss-Prot]
  • PRO1 Glutamate 5-kinase [mips]
  • Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis [SGD]
  • PRO1, Chr IV from 1061496-1062782, reverse complement [yeast_orfs2]
  • Chr IV from 1061496-1062782, reverse complement [yeastorf3.fasta]
  • Chr IV from 1062782-1061496, reverse complement [yeastorf5.fasta]
  • (P32264) Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) [4932.FASTACCERV.txt]
  • PRO1 SGDID:S0002708, Chr IV from 1062783-1061497, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PRO1 SGDID:S0002708, Chr IV from 1062785-1061499, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Gamma-glutamyl kinase, catalyzes the first step in proline biosythesis [Saccharomyces cerevisiae]gi|849219|gb|AAB64736.1| Pro1p: Glutamate 5-kinase (Swiss Prot. accession number P32264) [Saccharomyces cerevisiae]gi|2117897|pir||S61186 glutamate 5-kinase [nrdb_11152004_Chlamydomonas]
  • PRO1 SGDID:S000002708, Chr IV from 1062785-1061499, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PRO1 SGDID:S000002708, Chr IV from 1062787-1061501, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" [yeast-contam.fasta]
  • PRO1 SGDID:S000002708, Chr IV from 1062788-1061502, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Glutamate 5-kinase (Gamma-glutamyl kinase) (GK) [nr-271106-contam.fasta]
  • Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis; Pro1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Pro1p: Glutamate 5-kinase (Swiss Prot. accession number P32264) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Glutamate 5-kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRO1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PRO1 SGDID:S000002708, Chr IV from 1062791-1061505, Genome Release 64-1-1, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" [yeast-030211-contam.fasta]
  • PRO1 SGDID:S000002708, Chr IV from 1062791-1061505, Genome Release 64-2-1, reverse complement, Verified ORF, "Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR300C SGDID:S000002708, Chr IV from 1062791-1061505, Genome Release 64-1-1, reverse complement, Verified ORF, "Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 428 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    proline biosynthetic process [IDALink to PubMed article]
    Molecular Function: glutamate 5-kinase activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDANESKSY TIVIKLGSSS LVDEKTKEPK LAIMSLIVET VVKLRRMGHK VIIVSSGGIA  60
   61 VGLRTMRMNK RPKHLAEVQA IAAIGQGRLI GRWDLLFSQF DQRIAQILLT RNDILDWTQY 120
  121 KNAQNTINEL LNMGVIPIVN ENDTLSVREI KFGDNDTLSA ITSALIHADY LFLLTDVDCL 180
  181 YTDNPRTNPD AMPILVVPDL SKGLPGVNTA GGSGSDVGTG GMETKLVAAD LATNAGVHTL 240
  241 IMKSDTPANI GRIVEYMQTL ELDDENKVKQ AYNGDLTDLQ KREFEKLKAL NVPLHTKFIA 300
  301 NDNKHHLKNR EFWILHGLVS KGAVVIDQGA YAALTRKNKA GLLPAGVIDV QGTFHELECV 360
  361 DIKVGKKLPD GTLDPDFPLQ TVGKARCNYT SSELTKIKGL HSDQIEEELG YNDSEYVAHR 420
  421 ENLAFPPR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DNA2 HSP12 PRO1 RFA1 RFA2 RFA3
    View Details Gavin AC, et al. (2006) DUR1,2 MRPL22 PRO1 XKS1
    View Details Gavin AC, et al. (2002) BDF2 CCT4 CDC55 CHC1 CKB1 COG8 DYN1 ECM5 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GLE2 GLY1 GUT1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 IST1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PDC1 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RRP40 RRP46 RSC3 SAM1 SUI2 SUI3 TEL1 TSC11 USO1 UTP20 VTH2 XKS1 YFR006W YPR077C
    View Details Ho Y, et al. (2002) ARC1 AVO1 CPR1 FUM1 NOP58 PRO1 RAD1 RAD10 RNR2 RRP9 RRT6 SAH1 TFP1 TIF1, TIF2 UTP20

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..292] PSI-BLAST 29.045757 Carbamate kinase
    2 View Details [293..428] Pfam 22.200659 PUA domain No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle