YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	35 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ARP4	nucleus nuclear chromatin NuA4 histone acetyltransferase complex Swr1 complex Ino80 complex	DNA repair chromatin remodeling regulation of transcription, DNA-dependent histone acetylation chromatin organization regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity ATP-dependent 5'-3' DNA helicase activity chromatin binding
ARP5	nucleus Ino80 complex	chromatin remodeling protein targeting to vacuole	ATP-dependent 5'-3' DNA helicase activity
ARP6	cytoplasm Swr1 complex	chromatin remodeling histone exchange protein targeting to vacuole	nucleosome binding
ARP8	nucleus Ino80 complex	biological_process	ATP-dependent 5'-3' DNA helicase activity
CCA1	nucleus cytoplasm mitochondrial matrix mitochondrion	tRNA modification	tRNA adenylyltransferase activity
EAF1	NuA4 histone acetyltransferase complex histone acetyltransferase complex	chromatin modification DNA repair	molecular_function
EAF5	nucleus NuA4 histone acetyltransferase complex	DNA repair	molecular_function
EAF6	nucleus NuA4 histone acetyltransferase complex	DNA repair	molecular_function
EAF7	nucleus NuA4 histone acetyltransferase complex histone acetyltransferase complex	DNA repair histone acetylation regulation of transcription from RNA polymerase II promoter	molecular_function
EPL1	NuA4 histone acetyltransferase complex Piccolo NuA4 histone acetyltransferase complex histone acetyltransferase complex	DNA repair histone acetylation regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity
ESA1	NuA4 histone acetyltransferase complex Piccolo NuA4 histone acetyltransferase complex histone acetyltransferase complex	DNA repair RNA elongation histone acetylation regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity
IES1	nucleus Ino80 complex	chromatin remodeling	molecular_function
IES2	nucleus	biological_process	molecular_function
IES3	nucleus Ino80 complex	chromatin remodeling	molecular_function
IES4	nucleus	biological_process	molecular_function
IES5	nucleus	biological_process	molecular_function
IES6	nucleus	metabolic process	molecular_function
INO80	Ino80 complex	DNA repair chromatin remodeling transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
NHP10	nucleus Ino80 complex	chromatin remodeling	molecular_function
NTO1	nucleus cytoplasm	biological_process	molecular_function
PIH1	nucleus cytoplasm small nucleolar ribonucleoprotein complex	regulation of cell size rRNA processing protein folding	molecular_function
RVB1	nucleus Swr1 complex Ino80 complex chromatin remodeling complex	chromatin remodeling regulation of transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
RVB2	nucleus Swr1 complex Ino80 complex nuclear outer membrane chromatin remodeling complex	chromatin remodeling snoRNA metabolic process regulation of transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
SAS3	nuclear nucleosome histone acetyltransferase complex	chromatin modification chromatin silencing at silent mating-type cassette chromatin silencing at telomere	histone acetyltransferase activity acetyltransferase activity
SWC3	nucleus mitochondrion Swr1 complex	chromatin remodeling response to drug histone exchange endoplasmic reticulum organization	molecular_function
SWC4	nucleus NuA4 histone acetyltransferase complex Swr1 complex histone acetyltransferase complex	chromatin modification DNA repair chromatin remodeling histone exchange histone acetylation	DNA binding
SWC5	nucleus Swr1 complex	chromatin remodeling histone exchange	molecular_function
SWC7	nucleus Swr1 complex	chromatin remodeling	molecular_function
SWR1	nucleus Swr1 complex	chromatin remodeling histone exchange	structural molecule activity
TAH1	nucleus cytoplasm	protein folding	chaperone binding
TRA1	NuA4 histone acetyltransferase complex SLIK (SAGA-like) complex SAGA complex histone acetyltransferase complex	DNA repair histone acetylation regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity
VPS71	nucleus Swr1 complex	chromatin remodeling histone exchange protein targeting to vacuole	nucleosome binding
VPS72	nucleus cytoplasm Swr1 complex	chromatin remodeling histone exchange protein targeting to vacuole	histone binding
YAF9	nucleus NuA4 histone acetyltransferase complex cytoplasm Swr1 complex	DNA repair chromatin remodeling histone exchange chromatin silencing at telomere	molecular_function
YNG2	nucleus NuA4 histone acetyltransferase complex Piccolo NuA4 histone acetyltransferase complex histone acetyltransferase complex	chromatin modification DNA repair histone acetylation	enzyme activator activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear chromatin	4.7123E-29	35	73	19	6292
chromatin	1.4884E-28	35	77	19	6292
Swr1 complex	4.7253E-26	35	15	12	6292
chromatin remodeling complex	2.5412E-24	35	99	18	6292
H4/H2A histone acetyltransferase complex	9.8896E-24	35	14	11	6292
NuA4 histone acetyltransferase complex	9.8896E-24	35	14	11	6292
nuclear chromosome part	1.4224E-20	35	190	19	6292
DNA helicase complex	9.1017E-20	35	11	9	6292
Ino80 complex	9.1017E-20	35	11	9	6292
nuclear chromosome	4.8483E-19	35	228	19	6292
chromosomal part	1.0194E-18	35	237	19	6292
histone acetyltransferase complex	1.985E-18	35	44	12	6292
nucleus	6.32E-18	35	2041	35	6292
chromosome	1.6199E-17	35	274	19	6292
nuclear part	1.6222E-14	35	1103	27	6292
protein complex	3.5357E-14	35	1137	27	6292
macromolecular complex	3.1676E-11	35	1635	28	6292
nucleoplasm part	3.4979E-9	35	245	12	6292
nucleoplasm	8.1832E-9	35	264	12	6292
membrane-bounded organelle	1.5516E-8	35	3771	35	6292
intracellular membrane-bounded organelle	1.5516E-8	35	3771	35	6292
non-membrane-bounded organelle	9.0248E-8	35	959	19	6292
intracellular non-membrane-bounded organelle	9.0248E-8	35	959	19	6292
intracellular organelle part	1.4231E-7	35	2282	28	6292
organelle part	1.4231E-7	35	2282	28	6292
Piccolo NuA4 histone acetyltransferase complex	1.5773E-7	35	3	3	6292
intracellular organelle	2.2682E-7	35	4070	35	6292
organelle	2.2878E-7	35	4071	35	6292
nuclear lumen	3.0386E-6	35	453	12	6292
organelle lumen	2.7323E-5	35	660	13	6292
intracellular organelle lumen	2.7323E-5	35	660	13	6292
membrane-enclosed lumen	5.1267E-5	35	700	13	6292
intracellular part	2.0201E-4	35	4938	35	6292
intracellular	2.6256E-4	35	4975	35	6292
cell part	4.5803E-3	35	5397	35	6292
cell	4.6403E-3	35	5399	35	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
chromatin modification	1.0472E-30	35	168	24	6292
chromatin organization	1.2615E-28	35	203	24	6292
chromatin remodeling	1.6995E-25	35	68	17	6292
chromosome organization	5.0958E-18	35	555	24	6292
histone exchange	1.7329E-17	35	10	8	6292
ATP-dependent chromatin remodeling	5.6584E-13	35	26	8	6292
nucleosome organization	1.5368E-12	35	29	8	6292
organelle organization	5.3026E-11	35	1127	24	6292
DNA repair	2.0891E-10	35	192	12	6292
histone acetylation	6.4914E-10	35	36	7	6292
response to DNA damage stimulus	2.2792E-9	35	236	12	6292
protein amino acid acetylation	4.0024E-9	35	46	7	6292
cellular response to stress	2.36E-8	35	290	12	6292
protein amino acid acylation	2.4243E-8	35	59	7	6292
cellular component organization	7.4788E-8	35	1582	24	6292
covalent chromatin modification	4.0258E-7	35	88	7	6292
histone modification	4.0258E-7	35	88	7	6292
cellular response to stimulus	4.5203E-7	35	379	12	6292
response to stress	7.9948E-6	35	497	12	6292
DNA metabolic process	4.1952E-5	35	585	12	6292
cellular macromolecular complex subunit organization	6.6126E-5	35	259	8	6292
regulation of transcription, DNA-dependent	1.0647E-4	35	358	9	6292
regulation of RNA metabolic process	1.1848E-4	35	363	9	6292
response to stimulus	1.3181E-4	35	766	13	6292
regulation of transcription	1.822E-4	35	384	9	6292
regulation of transcription from RNA polymerase II promoter	2.1123E-4	35	228	7	6292
transcription, DNA-dependent	2.8678E-4	35	503	10	6292
RNA biosynthetic process	3.1087E-4	35	508	10	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.272E-4	35	415	9	6292
regulation of nitrogen compound metabolic process	3.3314E-4	35	416	9	6292
transcription from RNA polymerase II promoter	3.9407E-4	35	335	8	6292
protein targeting to vacuole	5.368E-4	35	69	4	6292
regulation of gene expression	5.4887E-4	35	445	9	6292
nucleic acid metabolic process	5.9594E-4	35	1415	17	6292
macromolecular complex subunit organization	6.0417E-4	35	357	8	6292
transcription	6.068E-4	35	552	10	6292
regulation of macromolecule biosynthetic process	6.5635E-4	35	456	9	6292
regulation of cellular biosynthetic process	8.4326E-4	35	472	9	6292
regulation of biosynthetic process	8.5627E-4	35	473	9	6292
regulation of macromolecule metabolic process	1.072E-3	35	488	9	6292
regulation of primary metabolic process	1.5504E-3	35	514	9	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	2.017E-3	35	1566	17	6292
regulation of cellular metabolic process	2.0797E-3	35	536	9	6292
regulation of metabolic process	2.3945E-3	35	547	9	6292
post-translational protein modification	3.0155E-3	35	357	7	6292
vacuolar transport	3.5816E-3	35	115	4	6292
RNA metabolic process	3.9195E-3	35	954	12	6292
cellular nitrogen compound metabolic process	7.9955E-3	35	1770	17	6292
nitrogen compound metabolic process	9.0737E-3	35	1791	17	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
ATP-dependent 5'-3' DNA helicase activity	1.3164E-13	35	7	6	6292
5'-3' DNA helicase activity	5.2446E-13	35	8	6	6292
ATP-dependent DNA helicase activity	3.3421E-10	35	18	6	6292
DNA helicase activity	2.2723E-8	35	34	6	6292
histone acetyltransferase activity	2.334E-8	35	17	5	6292
lysine N-acetyltransferase activity	2.334E-8	35	17	5	6292
ATP-dependent helicase activity	1.9613E-7	35	48	6	6292
purine NTP-dependent helicase activity	1.9613E-7	35	48	6	6292
DNA-dependent ATPase activity	4.5062E-7	35	55	6	6292
N-acetyltransferase activity	8.3988E-7	35	33	5	6292
N-acyltransferase activity	1.7412E-6	35	38	5	6292
helicase activity	5.2491E-6	35	83	6	6292
acetyltransferase activity	7.0065E-6	35	50	5	6292
nucleosome binding	3.0063E-5	35	2	2	6292
transferase activity, transferring acyl groups other than amino-acyl groups	1.3754E-4	35	92	5	6292
acyltransferase activity	1.3754E-4	35	92	5	6292
ATPase activity, coupled	1.4673E-4	35	149	6	6292
transferase activity, transferring acyl groups	2.8005E-4	35	107	5	6292
chromatin binding	7.6746E-4	35	33	3	6292
ATPase activity	9.5202E-4	35	211	6	6292
tRNA adenylyltransferase activity	5.5626E-3	35	1	1	6292
nucleoside-triphosphatase activity	8.7496E-3	35	329	6	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis