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Protein Overview: LEA1

General Information:
Name(s) found: LEA1 / YPL213W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    U2 snRNP [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: RNA binding [RCA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFTPSIVID APQYYVDHFN GKYNVDKCVI LRDLQLETDS ESMPSSLKHL TKPTHILDLT  60
   61 NNDLIMIPDL SRRDDIHTLL LGRNNIVEVD GRLLPMNVQN LTLSNNSIRR FEDLQRLRRA 120
  121 PRTLKNLTLI GNQVCHLANY REHVLRLVPH LETLDFQNVT AEERKSAMSF PRQADGDTLG 180
  181 PVNTAIRDNG SRDKTMEIMN LVVSKMTVER RNELKKQLAE ATSLEEIARL EKLLSGGV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CDC40 CLF1 CSN12 CUS1 CWC2 CWC23 DIB1 ECM2 HSH155 LEA1 MSL1 PRP11 PRP19 PRP21 PRP3 PRP31 PRP39 PRP4 PRP40 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SNT309 SNU114 SNU23 SNU66 SNU71 SPP382 STO1 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details Krogan NJ, et al. (2006) BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
    View Details Gavin AC, et al. (2006) BRR2 CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 RSE1 SMB1 SNU114 SNU23 SNU66 SPP381
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CDC40 CEF1 CLF1 CLU1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 KAP123 KGD1 KGD2 LEA1 LIN1 LPD1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SAM1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6 YMR31
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DIB1 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MSL1 MSL5 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP5 PRP6 PRP8 PRP9 RDS3 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 SUB2 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LEA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 63.751666 Splicesomal U2A' protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 5.06869554505412 bayes_pls_golite062009
  • RNA binding
    		•  2.76465666962243 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5631307925072 bayes_pls_golite062009
  • binding
    		•  1.28018794783241 bayes_pls_golite062009
  • mRNA binding
    		•  1.10345530526271 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.883701441647125 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle