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Protein Overview: MSH2

General Information:
Name(s) found: MSH2 / YOL090W [SGD]
Description(s) found:
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  • gi|6324482|ref|NP_014551.1| Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP [NCBI NR]
  • gi|600468|emb|CAA58189.1| orf 00935 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2506880|sp|P25847.2|MSH2_YEAST RecName: Full=DNA mismatch repair protein MSH2; AltName: Full=MutS protein homolog 2 [NCBI NR]
  • gi|1419934|emb|CAA99102.1| MSH2 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S57379 MSH2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • DNA mismatch repair protein MSH2 OS=Saccharomyces cerevisiae GN=MSH2 PE=1 SV=2 [Swiss-Prot]
  • MSH2 DNA mismatch repair protein [mips]
  • Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP [SGD]
  • (P25847) DNA mismatch repair protein MSH2 [4932.FASTACCERV.txt]
  • Chr XV from 147381-150275 [hmr_yeast5_DM3-1_pombe.fasta]
  • MSH2, Chr XV from 147381-150275 [yeast_orfs2]
  • MSH2 SGDID:S0005450, Chr XV from 147381-150275, Verified ORF [yeastflysequest.fasta]
  • Msh2p [Saccharomyces cerevisiae]gi|600468|emb|CAA58189.1| orf 00935 [Saccharomyces cerevisiae]gi|1419934|emb|CAA99102.1| MSH2 [Saccharomyces cerevisiae]gi|1362426|pir||S57379 MSH2 protein - yeast (Saccharomyces cerevisiae)gi|2506880|sp|P25847|MSH2_YEA [nrdb_11152004_Chlamydomonas]
  • MSH2 SGDID:S000005450, Chr XV from 147381-150275, Verified ORF, "Protein that forms heterodimers, with Msh3p and Msh6p, that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MSH2 SGDID:S000005450, Chr XV from 147382-150276, Verified ORF, "Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Ms [yeast-contam.fasta]
  • Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP; Msh2p [Saccharomyces cerev [nr-271106-contam.fasta]
  • DNA mismatch repair protein MSH2 [nr-271106-contam.fasta]
  • orf 00935 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MSH2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MSH2 SGDID:S000005450, Chr XV from 147382-150276, Verified ORF, "Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • DNA mismatch repair protein MSH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MSH2 SGDID:S000005450, Chr XV from 147382-150276, Genome Release 64-1-1, Verified ORF, "Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP" [yeast-030211-contam.fasta]
  • MSH2 SGDID:S000005450, Chr XV from 147382-150276, Genome Release 64-2-1, Verified ORF, "Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP" [20141208_orf_trans.fasta]
  • YOL090W SGDID:S000005450, Chr XV from 147382-150276, Genome Release 64-1-1, Verified ORF, "Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 964 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromosome [IDALink to PubMed article]
    Biological Process: removal of nonhomologous ends [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    meiotic gene conversion [IMPLink to PubMed article]
    meiotic mismatch repair [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mismatch repair [IMPLink to PubMed articleLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IGILink to PubMed article]
    mitotic recombination [IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    ATP binding [IDALink to PubMed article]
    double-strand/single-strand DNA junction binding [IDALink to PubMed article]
    DNA insertion or deletion binding [IDALink to PubMed article]
    loop DNA binding [IDALink to PubMed article]
    Y-form DNA binding [IDALink to PubMed article]
    four-way junction DNA binding [IDALink to PubMed articleLink to PubMed article]
    guanine/thymine mispair binding [IDALink to PubMed article]
    single base insertion or deletion binding [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTRPELKF SDVSEERNFY KKYTGLPKKP LKTIRLVDKG DYYTVIGSDA IFVADSVYHT  60
   61 QSVLKNCQLD PVTAKNFHEP TKYVTVSLQV LATLLKLCLL DLGYKVEIYD KGWKLIKSAS 120
  121 PGNIEQVNEL MNMNIDSSII IASLKVQWNS QDGNCIIGVA FIDTTAYKVG MLDIVDNEVY 180
  181 SNLESFLIQL GVKECLVQDL TSNSNSNAEM QKVINVIDRC GCVVTLLKNS EFSEKDVELD 240
  241 LTKLLGDDLA LSLPQKYSKL SMGACNALIG YLQLLSEQDQ VGKYELVEHK LKEFMKLDAS 300
  301 AIKALNLFPQ GPQNPFGSNN LAVSGFTSAG NSGKVTSLFQ LLNHCKTNAG VRLLNEWLKQ 360
  361 PLTNIDEINK RHDLVDYLID QIELRQMLTS EYLPMIPDIR RLTKKLNKRG NLEDVLKIYQ 420
  421 FSKRIPEIVQ VFTSFLEDDS PTEPVNELVR SVWLAPLSHH VEPLSKFEEM VETTVDLDAY 480
  481 EENNEFMIKV EFNEELGKIR SKLDTLRDEI HSIHLDSAED LGFDPDKKLK LENHHLHGWC 540
  541 MRLTRNDAKE LRKHKKYIEL STVKAGIFFS TKQLKSIANE TNILQKEYDK QQSALVREII 600
  601 NITLTYTPVF EKLSLVLAHL DVIASFAHTS SYAPIPYIRP KLHPMDSERR THLISSRHPV 660
  661 LEMQDDISFI SNDVTLESGK GDFLIITGPN MGGKSTYIRQ VGVISLMAQI GCFVPCEEAE 720
  721 IAIVDAILCR VGAGDSQLKG VSTFMVEILE TASILKNASK NSLIIVDELG RGTSTYDGFG 780
  781 LAWAIAEHIA SKIGCFALFA THFHELTELS EKLPNVKNMH VVAHIEKNLK EQKHDDEDIT 840
  841 LLYKVEPGIS DQSFGIHVAE VVQFPEKIVK MAKRKANELD DLKTNNEDLK KAKLSLQEVN 900
  901 EGNIRLKALL KEWIRKVKEE GLHDPSKITE EASQHKIQEL LRAIANEPEK ENDNYLKYIK 960
  961 ALLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MPH1 MSH2 MSH3 MSH6
    View Details (MIPS) Mewes HW, et al. (2004) MSH2 MSH3 MSH6 PMS1
    View Details Krogan NJ, et al. (2006) MSH2 MSH6
    View Details Gavin AC, et al. (2002) CMR1 DNA2 ECM29 HDA1 HDA2 HDA3 HSC82 KAP95 LCD1 MEC1 MGM101 MLH1 MPH1 MRPS28 MSH2 MSH3 MSH6 OLA1 PGK1 PMS1 PRO2 RAD16 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 RSC8 RVB2 SGS1 SHS1 SRO7 SSL1 TFA1 TFB1 TFB4 TIF1, TIF2 TOP3 VAS1 VPS1 YHR122W
    View Details Ho Y, et al. (2002) AI1 FUN12 HHO1 IMD2 IMD3 IMD4 MAG1 MPH1 MSH2 MSH6 NOP12 RET1 RPC82 TIF4631 TIF4632 UTP22
    View Details Qiu et al. (2008) MSH2 MSH6 PMS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 MSH2 1 Unpublished Fields Lab Data
    View Screen COG4 MSH2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MSH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] PSI-BLAST 1573.9794 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    2 View Details [119..292] PSI-BLAST 1573.9794 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    3 View Details [293..336]
    [631..883]    		 PSI-BLAST 1573.9794 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    4 View Details [337..503]
    [583..630]    		 PSI-BLAST 1573.9794 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    5 View Details [504..582] PSI-BLAST 1573.9794 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    6 View Details [884..964] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle