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Protein Overview: ILV2

General Information:
Name(s) found: ILV2 / YMR108W [SGD]
Description(s) found:
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  • gi|817866|emb|CAA89744.1| Ilv2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||YCBYI acetolactate synthase (EC 4.1.3.18) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6323755|ref|NP_013826.1| Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid [NCBI NR]
  • gi|51013441|gb|AAT93014.1| YMR108W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3825|emb|CAA26400.1| acetolactate synthase precursor [Saccharomyces cerevisiae] [NCBI NR]
  • gi|124376|sp|P07342.1|ILVB_YEAST RecName: Full=Acetolactate synthase catalytic subunit, mitochondrial; AltName: Full=Acetohydroxy-acid synthase catalytic subunit; Short=ALS; Short=AHAS; Flags: Precursor [NCBI NR]
  • Acetolactate synthase catalytic subunit, mitochondrial OS=Saccharomyces cerevisiae GN=ILV2 PE=1 SV=1 [Swiss-Prot]
  • ILV2 Acetolactate synthase [mips]
  • Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control [SGD]
  • ILV2, Chr XIII from 484083-486146 [yeast_orfs2]
  • Chr XIII from 484083-486146 [yeastorf3.fasta]
  • (P07342) Acetolactate synthase, mitochondrial precursor (EC 2.2.1.6) (Acetohydroxy-acid synthase) (ALS) (AHAS) [4932.FASTACCERV.txt]
  • ILV2 SGDID:S0004714, Chr XIII from 484083-486146, Verified ORF [yeastflysequest.fasta]
  • Acetolactate synthase, localizes in the mitochondria; expression of the gene is under general amino acid control [Saccharomyces cerevisiae]gi|51013441|gb|AAT93014.1| YMR108W [Saccharomyces cerevisiae]gi|3825|emb|CAA26400.1| acetolactate synthase precurs [nrdb_11152004_Chlamydomonas]
  • ILV2 SGDID:S000004714, Chr XIII from 484083-486146, Verified ORF, "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression o [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • acetolactate synthase precursor [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control; Ilv2p [Saccharomyce [nr-271106-contam.fasta]
  • Ilv2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Acetolactate synthase catalytic subunit, mitochondrial precursor (Acetohydroxy-acid synthase catalytic subunit) (ALS) (AHAS) [nr-271106-contam.fasta]
  • YMR108W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ILV2 SGDID:S000004714, Chr XIII from 484083-486146, Verified ORF, "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Acetolactate synthase catalytic subunit, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ILV2 SGDID:S000004714, Chr XIII from 484084-486147, Genome Release 64-1-1, Verified ORF, "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" [yeast-030211-contam.fasta]
  • ILV2 SGDID:S000004714, Chr XIII from 484084-486147, Genome Release 64-2-1, Verified ORF, "Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" [20141208_orf_trans.fasta]
  • TR5858|c0_g1_i1|g.4063 ORF TR5858|c0_g1_i1|g.4063 TR5858|c0_g1_i1|m.4063 type:complete len:688 (+) TR5858|c0_g1_i1:263-2326(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YMR108W SGDID:S000004714, Chr XIII from 484084-486147, Genome Release 64-1-1, Verified ORF, "Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_4342|g.3087 ORF asmbl_4342|g.3087 asmbl_4342|m.3087 type:complete len:688 (+) asmbl_4342:306-2369(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_4347|g.2508 ORF ID=asmbl_4347|g.2508 ID=asmbl_4347|m.2508 type:complete len:688 (+) ID=asmbl_4347:306-2369(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    acetolactate synthase complex [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: branched chain family amino acid biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: acetolactate synthase activity [IDALink to PubMed article][ISSLink to PubMed article]
    FAD binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRQSTLKNF AIKRCFQHIA YRNTPAMRSV ALAQRFYSSS SRYYSASPLP ASKRPEPAPS  60
   61 FNVDPLEQPA EPSKLAKKLR AEPDMDTSFV GLTGGQIFNE MMSRQNVDTV FGYPGGAILP 120
  121 VYDAIHNSDK FNFVLPKHEQ GAGHMAEGYA RASGKPGVVL VTSGPGATNV VTPMADAFAD 180
  181 GIPMVVFTGQ VPTSAIGTDA FQEADVVGIS RSCTKWNVMV KSVEELPLRI NEAFEIATSG 240
  241 RPGPVLVDLP KDVTAAILRN PIPTKTTLPS NALNQLTSRA QDEFVMQSIN KAADLINLAK 300
  301 KPVLYVGAGI LNHADGPRLL KELSDRAQIP VTTTLQGLGS FDQEDPKSLD MLGMHGCATA 360
  361 NLAVQNADLI IAVGARFDDR VTGNISKFAP EARRAAAEGR GGIIHFEVSP KNINKVVQTQ 420
  421 IAVEGDATTN LGKMMSKIFP VKERSEWFAQ INKWKKEYPY AYMEETPGSK IKPQTVIKKL 480
  481 SKVANDTGRH VIVTTGVGQH QMWAAQHWTW RNPHTFITSG GLGTMGYGLP AAIGAQVAKP 540
  541 ESLVIDIDGD ASFNMTLTEL SSAVQAGTPV KILILNNEEQ GMVTQWQSLF YEHRYSHTHQ 600
  601 LNPDFIKLAE AMGLKGLRVK KQEELDAKLK EFVSTKGPVL LEVEVDKKVP VLPMVAGGSG 660
  661 LDEFINFDPE VERQQTELRH KRTGGKH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ILV2 ILV6
    View Details Krogan NJ, et al. (2006) ILV2 PEX19 YDR053W YHR213W, YAR062W
    View Details Ho Y, et al. (2002) AAC3 AHA1 ATP3 AVO1 BEM2 CCT5 CLU1 DHH1 DPB2 ECM10 FUN12 GAL7 GCD11 GPH1 HOM3 HOR2 IDH1 ILV2 MET16 MKK2 MLH3 MLP2 NOG2 NPA3 OYE2 PDX1 PHO85 PIL1 PRB1 PTC3 PUF3 RAD52 RAD59 RHR2 RPN12 SEC27 SEC53 SIS1 SLX1 SRP54 STI1 TEF4 TEM1 TEP1 TFC7 UBA1 VMA8 YER077C YER138C YGR266W YKR051W YKU80 YLR271W YPR003C YPT31
    View Details Qiu et al. (2008) ILV2 ILV6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ILV2 Huh WK, et al. (2003)
    View Data ILV2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..274] PSI-BLAST 11000.0 Acetohydroxyacid synthase catalytic subunit
    2 View Details [275..460]
    [510..522]    		 PSI-BLAST 11000.0 Acetohydroxyacid synthase catalytic subunit
    3 View Details [461..509]
    [523..687]    		 PSI-BLAST 11000.0 Acetohydroxyacid synthase catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.51117258094456 bayes_pls_golite062009
  • transketolase activity
    		•  2.50501741089295 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • DNA binding
    		•  2.09930834951157 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  2.04735838056767 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00972611627502 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.91254869751164 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.90521776801103 bayes_pls_golite062009
  • thiamin pyrophosphate binding
    		•  1.87247313698582 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.85833680148029 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  1.65348126142808 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  1.20517690263403 bayes_pls_golite062009
  • binding
    		•  1.17940168894417 bayes_pls_golite062009
  • transcription factor binding
    		•  1.07103864164531 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0180828203704 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.98460927780383 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.982646671777 bayes_pls_golite062009
  • deacetylase activity
    		•  0.977680867213479 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • hydrolase activity
    		•  0.536729211484905 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.516307124442946 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.42635585193838 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.23414654967509 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle