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Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. Catalysis of the oxidative decarboxylation of pyruvate. Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: pyruvate dehydrogenase (acetyl-transferring) activity
Acc: GO:0004739
Aspect: Molecular Function
Desc: Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
Synonyms:
  • pyruvate dehydrogenase (lipoamide) activity
  • pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity
  • MtPDC (mitochondrial pyruvate dehydogenase complex) activity
  • PDH
  • pyruvate dehydrogenase complex activity
  • pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Proteins in PDR annotated with:
   This term: 49 [Search]
   Term or descendants: 49 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity (interactive image map)

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