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Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
Acc: GO:0003863
Aspect: Molecular Function
Desc: Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
Synonyms:
  • 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity
  • branched-chain (-2-oxoacid) dehydrogenase (BCD) activity
  • 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
  • BCKDH activity
  • branched-chain ketoacid dehydrogenase activity
  • branched-chain 2-keto acid dehydrogenase activity
  • BCOAD activity
  • branched-chain keto acid dehydrogenase activity
  • branched chain keto acid dehydrogenase activity
  • branched-chain alpha-keto acid dehydrogenase activity
  • 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity
  • alpha-keto-alpha-methylvalerate dehydrogenase activity
  • 2-oxoisocaproate dehydrogenase activity
  • 2-oxoisovalerate (lipoate) dehydrogenase activity
  • branched-chain alpha-oxo acid dehydrogenase activity
  • dehydrogenase, branched chain alpha-keto acid activity
  • alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity
  • alpha-oxoisocaproate dehydrogenase activity
  • alpha-ketoisovalerate dehydrogenase activity
  • dehydrogenase, 2-oxoisovalerate (lipoate) activity
  • alpha-ketoisocaproic dehydrogenase activity
  • alpha-ketoisocaproate dehydrogenase activity
  • branched-chain 2-oxo acid dehydrogenase activity
Proteins in PDR annotated with:
   This term: 16 [Search]
   Term or descendants: 16 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003863 - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity (interactive image map)

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Created and Maintained by: Michael Riffle