Protein Overview: ATG17

General Information:
Name(s) found:	ATG17 / YLR423C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|664879\|gb\|AAB67509.1\| Ylr423cp [Saccharomyces cerevisiae] [NCBI NR] gi\|6323455\|ref\|NP_013527.1\| Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway [NCBI NR] gi\|61211713\|sp\|Q06410.1\|ATG17_YEAST RecName: Full=Autophagy-related protein 17 [NCBI NR] pir\|\|S53410 hypothetical protein YLR423c - yeast (Saccharomyces cerevisiae) [NCBI NR] Autophagy-related protein 17 OS=Saccharomyces cerevisiae GN=ATG17 PE=1 SV=1 [Swiss-Prot] ATG17 Protein involved in authophagy [mips] Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity [SGD] APG17, Chr XII from 971912-973165, reverse complement [yeast_orfs2] Chr XII from 971912-973165, reverse complement [yeastorf3.fasta] Chr XII from 973165-971912, reverse complement [yeastorf5.fasta] >Q06410 (Q06410) SIMILARITY to cytokeratin 9 [4932.FASTACCERV.txt] ATG17 SGDID:S0004415, Chr XII from 973166-971913, reverse complement, Verified ORF [yeastflysequest.fasta] Atg17p [Saccharomyces cerevisiae]gi\|1078089\|pir\|\|S53410 hypothetical protein YLR423c - yeast (Saccharomyces cerevisiae)gi\|664879\|gb\|AAB67509.1\| Ylr423cp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] (Q06410) Ylr423cp [cerv4932.FASTAC] ATG17 SGDID:S000004415, Chr XII from 973166-971913, reverse complement, Verified ORF, "Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ATG17 SGDID:S000004415, Chr XII from 973167-971914, reverse complement, Verified ORF, "Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway" [yeast-contam.fasta] ATG17 SGDID:S000004415, Chr XII from 973167-971914, reverse complement, Verified ORF, "Scaffold protein responsible for pre-autophagosomal structure organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulat [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] ATG17 SGDID:S000004415, Chr XII from 973167-971914, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates A [yeast-200209-contam.fasta] Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway; Atg17p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ylr423cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Autophagy-related protein 17 [nr-271106-contam.fasta] ATG17 SGDID:S000004415, Chr XII from 973167-971914, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Autophagy-related protein 17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG17 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ATG17 SGDID:S000004415, Chr XII from 973170-971917, Genome Release 64-1-1, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells" [yeast-030211-contam.fasta] ATG17 SGDID:S000004415, Chr XII from 973170-971917, Genome Release 64-2-1, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells" [20141208_orf_trans.fasta] YLR423C SGDID:S000004415, Chr XII from 973170-971917, Genome Release 64-1-1, reverse complement, Verified ORF, "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	417 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	autophagy [IMP] telomere maintenance [IMP]
Molecular Function:	kinase activator activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEADVTKFV NNARKTLTDA QLLCSSANLR IVDIKKKLSS WQLSISKLNF LIVGLRQQGK  60
   61 FLYTILKEGI GTKLIQKQWN QAVLVVLVDE MKYWQYEITS KVQRLDGIVN ELSISEKDDT 120
  121 DPSKLGDYIS RDNVNLLNDK LKEVPVIERQ IENIKLQYEN MVRKVNKELI DTKLTDVTQK 180
  181 FQSKFGIDNL METNVAEQFS RELTDLEKDL AEIMNSLTQH FDKTLLLQDK KIDNDEREEL 240
  241 FKVVQGDDKE LYNIFKTLHE VIDDVDKTIL NLGQFLQAKI KEKTELHSEV SEIINDFNRN 300
  301 LEYLLIFKDI SNLIDSFKNS CTQDIQTTKE LCEFYDNFEE SYGNLVLEAK RRKDVANRMK 360
  361 TILKDCEKQL QNLDAQDQEE RQNFIAENGT YLPETIWPGK IDDFSSLYTL NYNVKNP

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ATG11 ATG17 ATG29 CIS1
View Details	Krogan NJ, et al. (2006)		ATG11 ATG17 ATG29 CIS1 THI11 YBR197C
View Details	Gavin AC, et al. (2006)		ATG11 ATG17 ATG29
View Details	Ho Y, et al. (2002)		AAC1 AAC3 ADE5,7 AHA1 ARC1 ARO1 ARP2 ARP4 ASA1 ATG11 ATG12 ATG17 ATG29 ATP3 CAR2 CDC33 CIC1 CIS1 CPA2 CPR6 CYS4 FET4 FOL2 GCD11 GFA1 GRH1 GUS1 HAP2 HAP5 HHF1, HHF2 IPI3 IPP1 LOC1 MAM33 MTQ1 NAP1 NMD5 NOP16 NSA2 POL5 PPX1 PRB1 PSE1 PTC7 Q0032 REP1 REX2 RHR2 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 SAH1 SAP190 SEC18 SPE3 SSK2 TCB1 TIF1, TIF2 TIF6 TYR1 YHR020W YHR033W YNL208W YRA1 YRA2 YTM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SAS3	ATG17	2	Unpublished Fields Lab Data
View Screen	ATG17	DAD2	2	Drees BL, et al. (2001)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ATG17	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..255]	PSI-BLAST	13.09691	Kinesin
2	View Details	[256..417]	ORFEUS	8.03	Heavy meromyosin subfragment

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	2.00548409930693	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.85030653553169	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.84811666933472	bayes_pls_golite062009
hydrolase activity	1.65763522573119	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.8469248456592	bayes_pls_golite062009
nucleic acid binding	0.836040413405389	bayes_pls_golite062009
DNA-dependent ATPase activity	0.70364355116614	bayes_pls_golite062009
motor activity	0.677658554107	bayes_pls_golite062009
kinase activity	0.641541011250583	bayes_pls_golite062009
pyrophosphatase activity	0.540750418412449	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.517457589081898	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.40876498215632	bayes_pls_golite062009
DNA binding	0.408392463724354	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.156278588350022	bayes_pls_golite062009
transcription regulator activity	0.117610930471173	bayes_pls_golite062009
microtubule motor activity	0.11674780318211	bayes_pls_golite062009
protein kinase activity	0.0646123847220056	bayes_pls_golite062009
helicase activity	0.0543669010112849	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.0223627159838333	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2