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Protein Overview: SOD1

General Information:
Name(s) found: SOD1 / YJR104C [SGD]
Description(s) found:
Found 50 descriptions.
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  • Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 154 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: age-dependent response to reactive oxygen species involved in chronological cell aging [TASLink to PubMed article]
    response to cold [IEPLink to PubMed article]
    superoxide metabolic process [IMPLink to PubMed article]
    cellular copper ion homeostasis [IGILink to PubMed article]
    response to drug [IMPLink to PubMed article]
    cellular zinc ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: antioxidant activity [IEA]
    metal ion binding [IEA]
    oxidoreductase activity [IEA]
    superoxide dismutase activity [IDA][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQAVAVLKG DAGVSGVVKF EQASESEPTT VSYEIAGNSP NAERGFHIHE FGDATNGCVS  60
   61 AGPHFNPFKK THGAPTDEVR HVGDMGNVKT DENGVAKGSF KDSLIKLIGP TSVVGRSVVI 120
  121 HAGQDDLGKG DTEESLKTGN AGPRPACGVI GLTN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCS1 CPR1 HYP2 SOD1
    View Details Krogan NJ, et al. (2006) CCS1 SOD1
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ACS2 ADE3 ADE6 ADH2 ADH4 ADO1 AFR1 AGX1 AHA1 AHP1 ALA1 APE2 ARA1 ARC1 ARF1 ATP3 BAT1 CAR2 CCT5 CDC10 CDC33 CLU1 CMD1 CMK2 CMP2 COF1 COR1 CPR1 CYR1 CYS3 CYS4 DED81 DPS1 DUN1 EDE1 EGD1 ERG10 ERG13 ERG20 ERG6 FOL2 FPR1 FRS2 GCD11 GCY1 GND1 GND2 GPH1 GRS1 GRX1 GUS1 HCH1 HEF3 HHF1, HHF2 HOM2 HYP2 ILS1 ILV5 IMD3 IPP1 KRS1 LRO1 LSP1 MDH3 MET6 MPC54 MYO2 MYO4 MYO5 NAP1 NMD3 NTF2 OLA1 OYE2 OYE3 PAB1 PDX3 PFK1 PFK2 PGM2 PHO81 PHO85 PIL1 PMI40 POR1 PRM2 PRP19 PRP6 PST2 PYC2 QCR2 RNR2 RSN1 SAC6 SAH1 SCP160 SEC53 SEN15 SES1 SHE3 SNU13 SOD1 SSZ1 TCP1 TEF4 THR4 THS1 TIF1, TIF2 TMA19 TMA29 TRR1 TSA2 UBA1 VAS1 VMA4 VMA5 VPS13 WTM1 YBL108W YCK1 YDL124W YHR112C YJU2 YMR315W YNK1
    View Details Qiu et al. (2008) ERV1 SOD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SOD1 Huh WK, et al. (2003)
    View Data SOD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] PSI-BLAST 812.70927 Cu,Zn superoxide dismutase, SOD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein phosphatase 2B binding
    		•  13.5719110466797 bayes_pls_golite062009
  • superoxide dismutase activity
    		•  12.1093323949609 bayes_pls_golite062009
  • oxidoreductase activity, acting on superoxide radicals as acceptor
    		•  12.1093323949609 bayes_pls_golite062009
  • chaperone binding
    		•  5.11696266714142 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  4.90125496493753 bayes_pls_golite062009
  • copper ion binding
    		•  4.51765925795625 bayes_pls_golite062009
  • protein phosphatase binding
    		•  3.26481550276071 bayes_pls_golite062009
  • phosphatase binding
    		•  3.1414149853516 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.451533032488 bayes_pls_golite062009
  • binding
    		•  2.28211284921339 bayes_pls_golite062009
  • protein binding
    		•  1.96660745768497 bayes_pls_golite062009
  • enzyme binding
    		•  1.82618630359051 bayes_pls_golite062009
  • cation binding
    		•  1.79413011653575 bayes_pls_golite062009
  • metal ion binding
    		•  1.79413011653575 bayes_pls_golite062009
  • ion binding
    		•  1.78699219376941 bayes_pls_golite062009
  • catalytic activity
    		•  1.09233965765942 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.658369569046781 bayes_pls_golite062009
  • metallochaperone activity
    		•  0.515959593535099 bayes_pls_golite062009
  • copper chaperone activity
    		•  0.412497194733789 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.32642292951469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.262312399748454 bayes_pls_golite062009
  • zinc ion binding
    		•  0.25600715352161 bayes_pls_golite062009
  • antioxidant activity
    		•  0.240491838042064 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle