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Protein Overview: SFB3

General Information:
Name(s) found: SFB3 / YHR098C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 929 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    peripheral to membrane of membrane fraction [IDALink to PubMed article][IPILink to PubMed article]
    COPII vesicle coat [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQQNILAAS VSALSLDEST VHTGGASSKK SRRPHRAYHN FSSGTVPTLG NSPYTTPQLN  60
   61 QQDGFQQPQA FTPKQFGGFN NGSGSVMSTP VMVSQERFGA SEASSPYGQS MLDMTAPQPT 120
  121 SHIVPTQRFE DQAQYLQRSF ETCRDSVPPL PTTQFYCVDQ GSCDPHLMSL SMYNIPESEH 180
  181 LRAATKLPLG LTIQPFSTLT PNDAEVPTIP LPMDGTPLRC RRCRAYANPK FQFTYDSSVI 240
  241 CNICRVKMQV PGEHFAPMGP NGQRSDLNEK SELLHGTVDF LVPSIYNAIQ EKELLPLHYV 300
  301 FLIDVSLLAN ENGSSLAMVE GVRSCIEYIS DFQPNCEVAI IVYDNKLRFF NLRPDLDNAQ 360
  361 EYIVSELDDV FLPFYNGLFV KPGNSMKIIN DTLIKISGYI STDKYSHVPQ VCYGSALQAA 420
  421 KLALDTVTGG QGGKIICSLN SLPTIGNGNL SLKRDNAHIA HVKCDNGFYK KLASDFLKSY 480
  481 ISLDLYVTNA GFIDMATVGH PVEMTSGILK YYPHFQQETD AFTLVNDMVT NVSNIVGYQA 540
  541 LLKVRCSTGL SVEQYYCDSS DNTDHDPIIP VLTRDTTLDV LLKYDSKIKT GTDVHFQTAL 600
  601 LYTDIDGVRK VRSINTSGAV SNNIREIFKF INQNPVMRIM IKDVIKTLGD CDFVKIRRLI 660
  661 DDKMVEILTQ YRGLVSSNSS TQLILPDSIK TLPAYMLAFE KSELMKPNAQ STRGNERIYD 720
  721 LLKYDSLNSA QLCYKLYPQI VPFHVLLEET DLTFYDANDK LLQINSSSIN NLSVRASHSN 780
  781 FINGGCYLIF QGDTIYLWFN ENTNRMLLQD LLSVDESLPV SQISLFSGTL PETGTSINQK 840
  841 ASNVIKNWQQ VVNKSSLPLV LLRPNVDQYY SNVMSQLLCE DKTVNRIESY DNYLVIMHKK 900
  901 IQEKLQKDDF IKVSTAATHE NIHQKFVQF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 CDC25 CKA2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 FPR3 GAS1 GCN3 GLC7 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TGL1 TMA19 TSR1 VMA4 YBR225W YER138C
    View Details Qiu et al. (2008) COG2 COG3 COP1 EMP24 ERP1 ERP2 ERV25 ERV46 SAR1 SEC13 SEC16 SEC21 SEC23 SEC24 SEC31 SFB2 SFB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SRO77 SFB3 2 Unpublished Fields Lab Data
    View Screen SNX41 SFB3 2 Unpublished Fields Lab Data
    View Screen ROM2 SFB3 2 Unpublished Fields Lab Data
    View Screen RAD51 SFB3 1 Unpublished Fields Lab Data
    View Screen THG1 SFB3 1 Hazbun TR, et al. (2003)
    View Screen SAM35 SFB3 1 Unpublished Fields Lab Data
    View Screen RPP0 SFB3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SFB3 Huh WK, et al. (2003)
    View Data SFB3 and SEC13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] PSI-BLAST 3.69897 Fibrinogen
    2 View Details [176..332] deduced N/A No confident structure predictions are available.
    3 View Details [333..650] MSA 1.049916 View MSA. No confident structure predictions are available.
    4 View Details [651..707] deduced N/A No confident structure predictions are available.
    5 View Details [708..929] MSA 3.051968 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.9315281375853 bayes_pls_golite062009
  • binding
    		•  1.90456497151578 bayes_pls_golite062009
  • transporter activity
    		•  1.30184925420876 bayes_pls_golite062009
  • collagen binding
    		•  0.568860931913098 bayes_pls_golite062009
  • integrin binding
    		•  0.56855067092085 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.464562340940318 bayes_pls_golite062009
  • protein complex binding
    		•  0.35582708645524 bayes_pls_golite062009
  • DNA binding
    		•  0.155617838235236 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0661625326929309 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.027305897174472 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0179622467180781 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0153681945260867 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle