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Protein Overview: SEC24

General Information:
Name(s) found: SEC24 / YIL109C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 926 amino acids

    Gene Ontology:
    Cellular Component: COPII vesicle coat [TASLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    autophagy [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHKKRVYP QAQLQYGQNA TPLQQPAQFM PPQDPAAAGM SYGQMGMPPQ GAVPSMGQQQ  60
   61 FLTPAQEQLH QQIDQATTSM NDMHLHNVPL VDPNAYMQPQ VPVQMGTPLQ QQQQPMAAPA 120
  121 YGQPSAAMGQ NMRPMNQLYP IDLLTELPPP ITDLTLPPPP LVIPPERMLV PSELSNASPD 180
  181 YIRSTLNAVP KNSSLLKKSK LPFGLVIRPY QHLYDDIDPP PLNEDGLIVR CRRCRSYMNP 240
  241 FVTFIEQGRR WRCNFCRLAN DVPMQMDQSD PNDPKSRYDR NEIKCAVMEY MAPKEYTLRQ 300
  301 PPPATYCFLI DVSQSSIKSG LLATTINTLL QNLDSIPNHD ERTRISILCV DNAIHYFKIP 360
  361 LDSENNEESA DQINMMDIAD LEEPFLPRPN SMVVSLKACR QNIETLLTKI PQIFQSNLIT 420
  421 NFALGPALKS AYHLIGGVGG KIIVVSGTLP NLGIGKLQRR NESGVVNTSK ETAQLLSCQD 480
  481 SFYKNFTIDC SKVQITVDLF LASEDYMDVA SLSNLSRFTA GQTHFYPGFS GKNPNDIVKF 540
  541 STEFAKHISM DFCMETVMRA RGSTGLRMSR FYGHFFNRSS DLCAFSTMPR DQSYLFEVNV 600
  601 DESIMADYCY VQVAVLLSLN NSQRRIRIIT LAMPTTESLA EVYASADQLA IASFYNSKAV 660
  661 EKALNSSLDD ARVLINKSVQ DILATYKKEI VVSNTAGGAP LRLCANLRMF PLLMHSLTKH 720
  721 MAFRSGIVPS DHRASALNNL ESLPLKYLIK NIYPDVYSLH DMADEAGLPV QTEDGEATGT 780
  781 IVLPQPINAT SSLFERYGLY LIDNGNELFL WMGGDAVPAL VFDVFGTQDI FDIPIGKQEI 840
  841 PVVENSEFNQ RVRNIINQLR NHDDVITYQS LYIVRGASLS EPVNHASARE VATLRLWASS 900
  901 TLVEDKILNN ESYREFLQIM KARISK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) EMP24 ERP1 ERP2 ERV25 ERV46 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31
    View Details Krogan NJ, et al. (2006) BUG1 GRH1 SEC23 SEC24 SFB2
    View Details Gavin AC, et al. (2006) SEC13 SEC16 SEC23 SEC24 SFB2
    View Details Qiu et al. (2008) EMP24 ERP1 ERP2 ERV25 ERV46 RET2 SAR1 SEC13 SEC16 SEC21 SEC23 SEC24 SEC31 SFB2 SFB3 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC24 and SEC13 Huh WK, et al. (2003)
    View Data SEC24 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] ORFEUS 13.79 No description for 1ldvA was found.
    2 View Details [280..339] deduced N/A No confident structure predictions are available.
    3 View Details [340..691] MSA 1.05192 View MSA. No confident structure predictions are available.
    4 View Details [692..778] deduced N/A No confident structure predictions are available.
    5 View Details [779..844] PSI-BLAST 2.69897 Severin, domain 2
    6 View Details [845..926] ORFEUS 9.91 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.9315281375853 bayes_pls_golite062009
  • binding
    		•  1.90456497151578 bayes_pls_golite062009
  • transporter activity
    		•  1.30184925420876 bayes_pls_golite062009
  • collagen binding
    		•  0.568860931913098 bayes_pls_golite062009
  • integrin binding
    		•  0.56855067092085 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.464562340940318 bayes_pls_golite062009
  • protein complex binding
    		•  0.35582708645524 bayes_pls_golite062009
  • DNA binding
    		•  0.155617838235236 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0661625326929309 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.027305897174472 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0179622467180781 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0153681945260867 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle