Protein Overview: SEC24

General Information:
Name(s) found:	SEC24 / YIL109C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731857\|sp\|P40482.1\|SEC24_YEAST RecName: Full=Protein transport protein SEC24; AltName: Full=Abnormal nuclear morphology 1 [NCBI NR] gi\|6322082\|ref\|NP_012157.1\| Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1 [NCBI NR] pir\|\|S48463 SEC24 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|558697\|emb\|CAA86271.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|51013227\|gb\|AAT92907.1\| YIL109C [Saccharomyces cerevisiae] [NCBI NR] gi\|24158938\|pdb\|1M2V\|B Chain B, Crystal Structure Of The Yeast Sec2324 HETERODIMER [NCBI NR] Protein transport protein SEC24 OS=Saccharomyces cerevisiae GN=SEC24 PE=1 SV=1 [Swiss-Prot] (P40482) Protein transport protein Sec24 (Abnormal nuclear morphology 1) [Swiss-Prot] SEC24 Component of COPII coat of ER-Golgi vesicles [mips] Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p [SGD] SEC24, Chr IX from 157382-160162, reverse complement [yeast_orfs2] Chr IX from 157382-160162, reverse complement [yeastorf3.fasta] Chr IX from 160162-157382, reverse complement [yeastorf5.fasta] SEC24 SGDID:S0001371, Chr IX from 160162-157382, reverse complement, Verified ORF [yeastflysequest.fasta] Sec24p [Saccharomyces cerevisiae]gi\|51013227\|gb\|AAT92907.1\| YIL109C [Saccharomyces cerevisiae]gi\|558697\|emb\|CAA86271.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626367\|pir\|\|S48463 SEC24 protein - yeast (Saccharomyces cerevisiae)gi\|731857\|s [nrdb_11152004_Chlamydomonas] SEC24 SGDID:S000001371, Chr IX from 160162-157382, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the bindin [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Chain B, Crystal Structure Of The Yeast Sec2324 HETERODIMER [nr-271106-contam.fasta] Protein transport protein SEC24 (Abnormal nuclear morphology 1) [nr-271106-contam.fasta] Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p; Sec24p [Sacchar [nr-271106-contam.fasta] YIL109C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SEC24 SGDID:S000001371, Chr IX from 160162-157382, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Protein transport protein SEC24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC24 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SEC24 SGDID:S000001371, Chr IX from 160165-157385, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p" [yeast-030211-contam.fasta] SEC24 SGDID:S000001371, Chr IX from 160165-157385, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YIL109C SGDID:S000001371, Chr IX from 160165-157385, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	926 amino acids
Gene Ontology:
Cellular Component:	COPII vesicle coat [TAS]
Biological Process:	ER to Golgi vesicle-mediated transport [TAS] autophagy [IMP]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHKKRVYP QAQLQYGQNA TPLQQPAQFM PPQDPAAAGM SYGQMGMPPQ GAVPSMGQQQ  60
   61 FLTPAQEQLH QQIDQATTSM NDMHLHNVPL VDPNAYMQPQ VPVQMGTPLQ QQQQPMAAPA 120
  121 YGQPSAAMGQ NMRPMNQLYP IDLLTELPPP ITDLTLPPPP LVIPPERMLV PSELSNASPD 180
  181 YIRSTLNAVP KNSSLLKKSK LPFGLVIRPY QHLYDDIDPP PLNEDGLIVR CRRCRSYMNP 240
  241 FVTFIEQGRR WRCNFCRLAN DVPMQMDQSD PNDPKSRYDR NEIKCAVMEY MAPKEYTLRQ 300
  301 PPPATYCFLI DVSQSSIKSG LLATTINTLL QNLDSIPNHD ERTRISILCV DNAIHYFKIP 360
  361 LDSENNEESA DQINMMDIAD LEEPFLPRPN SMVVSLKACR QNIETLLTKI PQIFQSNLIT 420
  421 NFALGPALKS AYHLIGGVGG KIIVVSGTLP NLGIGKLQRR NESGVVNTSK ETAQLLSCQD 480
  481 SFYKNFTIDC SKVQITVDLF LASEDYMDVA SLSNLSRFTA GQTHFYPGFS GKNPNDIVKF 540
  541 STEFAKHISM DFCMETVMRA RGSTGLRMSR FYGHFFNRSS DLCAFSTMPR DQSYLFEVNV 600
  601 DESIMADYCY VQVAVLLSLN NSQRRIRIIT LAMPTTESLA EVYASADQLA IASFYNSKAV 660
  661 EKALNSSLDD ARVLINKSVQ DILATYKKEI VVSNTAGGAP LRLCANLRMF PLLMHSLTKH 720
  721 MAFRSGIVPS DHRASALNNL ESLPLKYLIK NIYPDVYSLH DMADEAGLPV QTEDGEATGT 780
  781 IVLPQPINAT SSLFERYGLY LIDNGNELFL WMGGDAVPAL VFDVFGTQDI FDIPIGKQEI 840
  841 PVVENSEFNQ RVRNIINQLR NHDDVITYQS LYIVRGASLS EPVNHASARE VATLRLWASS 900
  901 TLVEDKILNN ESYREFLQIM KARISK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		EMP24 ERP1 ERP2 ERV25 ERV46 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31
View Details	Krogan NJ, et al. (2006)		BUG1 GRH1 SEC23 SEC24 SFB2
View Details	Gavin AC, et al. (2006)		SEC13 SEC16 SEC23 SEC24 SFB2
View Details	Qiu et al. (2008)		EMP24 ERP1 ERP2 ERV25 ERV46 RET2 SAR1 SEC13 SEC16 SEC21 SEC23 SEC24 SEC31 SFB2 SFB3 YOS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SEC24 and SEC13	Huh WK, et al. (2003)
View Data	SEC24	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..279]	ORFEUS	13.79	No description for 1ldvA was found.
2	View Details	[280..339]	deduced	N/A	No confident structure predictions are available.
3	View Details	[340..691]	MSA	1.05192	View MSA. No confident structure predictions are available.
4	View Details	[692..778]	deduced	N/A	No confident structure predictions are available.
5	View Details	[779..844]	PSI-BLAST	2.69897	Severin, domain 2
6	View Details	[845..926]	ORFEUS	9.91	Sec24

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: SEC24

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: