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Protein Overview: LCP5

General Information:
Name(s) found: LCP5 / YER127W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [TASLink to PubMed article]
    small nuclear ribonucleoprotein complex [TASLink to PubMed article]
    small nucleolar ribonucleoprotein complex [TASLink to PubMed article]
    Biological Process: rRNA modification [TASLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELNALLKD INGSLTATSE SLERLSGIYS NSATDEIPES NQLHEHLFYD AKKPAEKVSL  60
   61 LSLKNGSMLG YINSLLMLIG NRLDDECKDP SAMDARERSI QHRVVLERGV KPLEKKLAYQ 120
  121 LDKLTRAYVK MEKEYKDAEK RALEKSTLVN HSGNDDSEDD ESSEDEIAYR PNTSGIINTN 180
  181 KKSSAYRVEE TAKQENGEEN DDNETGVYKP PKITAVLPPQ QTHFEDRFDA REHKDRSNKS 240
  241 RMQAMEEYIR ESSDQPDWSA SIGADIVNHG RGGIKSLRDT EKERRVTSFE EDNFTRLNIT 300
  301 NKAEKRKQKQ RERNARMNVI GGEDFGIFSS KRKLEDSTSR RGAKKTRSAW DRAQRRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 ENP2 HCA4 KRE33 LCP5 RPS11A, RPS11B
    View Details Hazbun TR, et al. (2003) BFR2 ENP2 ESF1 HCA4 LCP5 NOP58 UTP9
    View Details Krogan NJ, et al. (2006) BFR2 FUN14 HCA4 KRE33 LCP5
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 GCN1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP14 NOP56 NOP58 NOP6 PNO1 PRE6 PRE9 PRP43 PWP2 RCL1 RML2 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C
    View Details Ho Y, et al. (2002) CKA1 CKA2 CKB1 CKB2 DIP2 ESL2 KRE33 LCP5 NAN1 NOP1 NOP56 PNO1 PRP40 PTC5 PWP2 RRP5 TFP1 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6
    View Details Qiu et al. (2008) ENP1 GAR1 IMP3 LCP5 PWP2 RRP9 SOF1 UTP13 UTP14 UTP15 UTP20 UTP22 UTP7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPP382 LCP5 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] MSA 1.011983 View MSA. No confident structure predictions are available.
    2 View Details [130..357] deduced N/A No confident structure predictions are available.
    3 View Details [255..357] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle