Protein Overview: HXT6

General Information:
Name(s) found:	HXT6 / YDR343C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6320550\|ref\|NP_010630.1\| High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; Hxt6p [Saccharomy [NCBI NR] gi\|1708367\|sp\|P39003.2\|HXT6_YEAST RecName: Full=High-affinity hexose transporter HXT6 [NCBI NR] gi\|1230670\|gb\|AAB64779.1\| Hxt6p: Hexose transporter (Swiss Prot. accession number P39003) [Saccharomyces cerevisiae] [NCBI NR] High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae GN=HXT6 PE=1 SV=2 [Swiss-Prot] HXT6 High-affinity hexose facilitator [mips] High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 [SGD] HXT6, Chr IV from 1159598-1161310, reverse complement [yeast_orfs2] Chr IV from 1159598-1161310, reverse complement [yeastorf3.fasta] Chr IV from 1159597-1161309, reverse complement [yeastorf4.fasta] Chr IV from 1161309-1159597, reverse complement [yeastorf5.fasta] (P39003) High-affinity hexose transporter HXT6 [4932.FASTACCERV.txt] HXT6 SGDID:S0002751, Chr IV from 1161310-1159598, reverse complement, Verified ORF [yeastflysequest.fasta] HXT6 SGDID:S0002751, Chr IV from 1161312-1159600, reverse complement, Verified ORF [10112005cervSGD.fasta] High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 [Saccharomyces cerevisiae]gi\|1230670\|gb\|AAB64 [nrdb_11152004_Chlamydomonas] HXT6 SGDID:S000002751, Chr IV from 1161312-1159600, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HXT6 SGDID:S000002751, Chr IV from 1161314-1159602, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of [yeast-contam.fasta] HXT6 SGDID:S000002751, Chr IV from 1161315-1159603, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Hxt6p: Hexose transporter (Swiss Prot. accession number P39003) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] High-affinity hexose transporter HXT6 [nr-271106-contam.fasta] High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; Hxt6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] HXT6 SGDID:S000002751, Chr IV from 1161315-1159603, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3" [yeast-bovrabprots.fasta] HXT6 SGDID:S000002751, Chr IV from 1161314-1159602, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3" [yeast-contam_custom.fasta] [chemostatdb.fasta] High-affinity hexose transporter HXT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT6 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HXT6 SGDID:S000002751, Chr IV from 1161320-1159608, Genome Release 64-1-1, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3" [yeast-030211-contam.fasta] HXT6 SGDID:S000002751, Chr IV from 1161320-1159608, Genome Release 64-2-1, reverse complement, Verified ORF, "High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YDR343C SGDID:S000002751, Chr IV from 1161320-1159608, Genome Release 64-1-1, reverse complement, Verified ORF, "High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	570 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] plasma membrane [ISS]
Biological Process:	hexose transport [TAS]
Molecular Function:	fructose transmembrane transporter activity [TAS] glucose transmembrane transporter activity [IDA][TAS] mannose transmembrane transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDAAIAEQ TPVEHLSAVD SASHSVLSTP SNKAERDEIK AYGEGEEHEP VVEIPKRPAS  60
   61 AYVTVSIMCI MIAFGGFVFG WDTGTISGFI NQTDFIRRFG MKHKDGTNYL SKVRTGLIVS 120
  121 IFNIGCAIGG IILSKLGDMY GRKVGLIVVV VIYIIGIIIQ IASINKWYQY FIGRIISGLG 180
  181 VGGIAVLSPM LISEVSPKHL RGTLVSCYQL MITAGIFLGY CTNFGTKNYS NSVQWRVPLG 240
  241 LCFAWALFMI GGMTFVPESP RYLAEVGKIE EAKRSIAVSN KVAVDDPSVL AEVEAVLAGV 300
  301 EAEKLAGNAS WGELFSSKTK VLQRLIMGAM IQSLQQLTGD NYFFYYGTTI FKAVGLSDSF 360
  361 ETSIVLGIVN FASTFVGIYV VERYGRRTCL LWGAASMTAC MVVYASVGVT RLWPNGQDQP 420
  421 SSKGAGNCMI VFACFYIFCF ATTWAPIPYV VVSETFPLRV KSKAMSIATA ANWLWGFLIG 480
  481 FFTPFITGAI NFYYGYVFMG CLVFMFFYVL LVVPETKGLT LEEVNTMWEE GVLPWKSASW 540
  541 VPPSRRGANY DAEEMAHDDK PLYKRMFSTK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		HXT6 HXT7
View Details	Ho Y, et al. (2002)		AAC3 ACO1 ADK1 ARP7 ART10 ATP3 AVO1 BCY1 BUL1 BZZ1 CAR2 CCL1 CPR6 DIG1 DIG2 EMI2 ESS1 FET4 GFA1 GLC7 GUS1 HAS1 HEF3 HOR2 HSP104 HXT6 HXT7 KOG1 KSS1 LAS17 LSB1 LSC1 LSP1 MDN1 MET18 MKT1 MSE1 MYO4 NAP1 NET1 NOP6 NSR1 PDC6 PEP1 PHO84 PIL1 PIM1 PKH2 PMA1 PMA2 PPZ2 PSR2 PUP2 PYC1 RAD3 REG1 RGC1 RHR2 RNQ1 RPA135 RPB3 RPB5 RPN1 RPN10 RPO21 RPO26 RPT3 RSE1 RSP5 RVB1 RVS167 SDS22 SEN1 SES1 SIW14 SLA1 SNF4 SPT5 STE12 STE7 TEC1 TFG1 TFP1 THI22 TIM21 TOM1 UBI4 UTP22 VRP1 YBL036C YDR239C YGR130C YHR033W YKR018C YNR065C
View Details	Qiu et al. (2008)		HXT4 HXT6 HXT7

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	YNL313C	No Comments	Hazbun TR, et al. (2003)
View Run	YMR185W	No Comments	Hazbun TR, et al. (2003)
View Run	MIA40	No Comments	Hazbun TR, et al. (2003)
View Run	GWT1	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YLR224W	HXT6	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	HXT6	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..257] [306..517]	PSI-BLAST	504.0103	No description for 1ja5A_ was found.
2	View Details	[258..305] [518..570]	PSI-BLAST	504.0103	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.74077413704789	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar binding	0.285073104957756	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2