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Protein Overview: PKH2

General Information:
Name(s) found: PKH2 / YOL100W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1081 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: MAPKKK cascade involved in cell wall biogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFDKDNSMS PRPLLPSDEQ KLNINLLTKK EKFSHLDPHY DAKATPQRST SNRNVGDLLL  60
   61 EKRTAKPMIQ KALTNTDNFI EMYHNQQRKN LDDDTIKEVM INDENGKTVA STNDGRYDND 120
  121 YDNNDINDQK TLDNIAGSPH MEKNRNKVKI EHDSSSQKPI AKESSKAQKN IIKKGIKDFK 180
  181 FGSVIGDGAY STVMLATSID TKKRYAAKVL NKEYLIRQKK VKYVSIEKTA LQKLNNSPSV 240
  241 VRLFSTFQDE SSLYFLLEYA PNGDFLSLMK KYGSLDETCA RYYAAQIIDA IDYLHSNGII 300
  301 HRDIKPENIL LDGEMKIKLT DFGTAKLLNP TNNSVSKPEY DLSTRSKSFV GTAEYVSPEL 360
  361 LNDSFTDYRC DIWAFGCILF QMIAGKPPFK ATNEYLTFQK VMKVQYAFTP GFPLIIRDLV 420
  421 KKILVKNLDR RLTISQIKEH HFFKDLNFKD GSVWSKTPPE IKPYKINAKS MQAMPSGSDR 480
  481 KLVKKSVNTL GKSHLVTQRS ASSPSVEETT HSTLYNNNTH ASTESEISIK KRPTDERTAQ 540
  541 ILENARKGIN NRKNQPGKRT PSGAASAALA ASAALTKKTM QSYPTSSSKS SRSSSPATTS 600
  601 RPGTYKRTSS TESKPFAKSP PLSASVLSSK VPMPPYTPPM SPPMTPYDTY QMTPPYTTKQ 660
  661 QDYSDTAIAA PKPCISKQNV KNSTDSPLMN KQDIQWSFYL KNINEHVLRT EKLDFVTTNY 720
  721 DILEKKMLKL NGSLLDPQLF GKPRHTFLSQ VARSGGEVTG FRNDPTMTAY SKTEDTYYSK 780
  781 NIIDLQLLED DYRIEGGDLS ELLTNRSGEG YKCNQNSSPM KDDDKSESNN KGSSVFSGKI 840
  841 KKLFHPTSAA ETLSSSDEKT KYYKRTIVMT SFGRFLVFAK RRQPNPVTNL KYELEYDINL 900
  901 RQQGTKIKEL IIPLEMGTNH IVVIQTPYKS FLLSTDKKTT SKLFTVLKKI LNSNTNKIEK 960
  961 ELLQRNQKVI ERRTSSSGRA IPKDLPTSKS PSPKPRTHSQ SPSISKHNSF SESINSAKSN1020
 1021 RSSRIFETFI NAKEQNSKKH AAPVPLTSKL VNGLPKRQVT VGLGLNTGTN FKNSSAKSKR1080
 1081 S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) HXT6 HXT7 LSP1 PIL1 PKH2 TIM21

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PKH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 15.522879 C2 domain from protein kinase c (beta)
    2 View Details [133..228]
    [243..259]
    [464..499]    		 PSI-BLAST 573.9897 cAMP-dependent PK, catalytic subunit
    3 View Details [229..242]
    [260..463]    		 PSI-BLAST 573.9897 cAMP-dependent PK, catalytic subunit
    4 View Details [500..815] ORFEUS 13.24 RBP1
    5 View Details [816..1081] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • phospholipid binding
    		•  0.98776359922762 bayes_pls_golite062009
  • transporter activity
    		•  0.698425581375283 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  0.688833750465289 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.172018617171784 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  0.242410242748222 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle