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View Structure Prediction Details

Protein: PKH2
Organism: Saccharomyces cerevisiae
Length: 1081 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PKH2.

Description E-value Query
Range		 Subject
Range
PKH2 - Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls en...
PKH2_YEAST - Serine/threonine-protein kinase PKH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKH...
 0.0 [1..1081] [1..1081]
gi|2822146 - gi|2822146|gb|AAB97933.1| Protein kinase C beta (5' partial) splice form_1 [Homo sapiens]
 0.0 [11..509] [3..489]
KPCB_RABIT - Protein kinase C beta type OS=Oryctolagus cuniculus GN=PRKCB PE=2 SV=3
 0.0 [11..509] [180..666]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [11..509] [180..666]
KPCB_BOVIN - Protein kinase C beta type OS=Bos taurus GN=PRKCB PE=2 SV=3
 0.0 [11..509] [180..665]
KPCB_MOUSE - Protein kinase C beta type OS=Mus musculus GN=Prkcb PE=1 SV=3
sp|P68403-2|KPCB_RAT - Isoform Beta-II of Protein kinase C beta type OS=Rattus norvegicus GN=Prkcb
gi|117616654 - gi|117616654|gb|ABK42345.1| protein kinase C beta2 [synthetic construct]
 0.0 [11..509] [180..665]
gi|206189 - gi|206189|gb|AAA41875.1| protein kinase C type II
 0.0 [11..509] [180..665]

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Predicted Domain #1
Region A:
Residues: [1-132] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYFDKDNSMS PRPLLPSDEQ KLNINLLTKK EKFSHLDPHY DAKATPQRST SNRNVGDLLL  60
   61 EKRTAKPMIQ KALTNTDNFI EMYHNQQRKN LDDDTIKEVM INDENGKTVA STNDGRYDND 120
  121 YDNNDINDQK TL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 1a25A_
Description: C2 domain from protein kinase c (beta)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.77482286467294 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
phospholipid binding 0.98776359922762 bayes_pls_golite062009
transporter activity 0.698425581375283 bayes_pls_golite062009
calcium-dependent phospholipid binding 0.688833750465289 bayes_pls_golite062009
profilin binding 0.32399339703241 bayes_pls_golite062009
substrate-specific transporter activity 0.172018617171784 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [133-228] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNIAGSPHME KNRNKVKIEH DSSSQKPIAK ESSKAQKNII KKGIKDFKFG SVIGDGAYST  60
   61 VMLATSIDTK KRYAAKVLNK EYLIRQKKVK YVSIEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [243-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFSTFQDESS LYFLLEY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [464-499] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKINAKSMQA MPSGSDRKLV KKSVNTLGKS HLVTQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 573.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.04467222534257 bayes_pls_golite062009
kinase activity 4.85903980916957 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
MAP kinase kinase activity 0.610230065465794 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [229-242] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TALQKLNNSP SVVR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [260-463] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APNGDFLSLM KKYGSLDETC ARYYAAQIID AIDYLHSNGI IHRDIKPENI LLDGEMKIKL  60
   61 TDFGTAKLLN PTNNSVSKPE YDLSTRSKSF VGTAEYVSPE LLNDSFTDYR CDIWAFGCIL 120
  121 FQMIAGKPPF KATNEYLTFQ KVMKVQYAFT PGFPLIIRDL VKKILVKNLD RRLTISQIKE 180
  181 HHFFKDLNFK DGSVWSKTPP EIKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 573.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [500-815] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASSPSVEET THSTLYNNNT HASTESEISI KKRPTDERTA QILENARKGI NNRKNQPGKR  60
   61 TPSGAASAAL AASAALTKKT MQSYPTSSSK SSRSSSPATT SRPGTYKRTS STESKPFAKS 120
  121 PPLSASVLSS KVPMPPYTPP MSPPMTPYDT YQMTPPYTTK QQDYSDTAIA APKPCISKQN 180
  181 VKNSTDSPLM NKQDIQWSFY LKNINEHVLR TEKLDFVTTN YDILEKKMLK LNGSLLDPQL 240
  241 FGKPRHTFLS QVARSGGEVT GFRNDPTMTA YSKTEDTYYS KNIIDLQLLE DDYRIEGGDL 300
  301 SELLTNRSGE GYKCNQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.24
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [816-1081] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPMKDDDK SESNNKGSSV FSGKIKKLFH PTSAAETLSS SDEKTKYYKR TIVMTSFGRF  60
   61 LVFAKRRQPN PVTNLKYELE YDINLRQQGT KIKELIIPLE MGTNHIVVIQ TPYKSFLLST 120
  121 DKKTTSKLFT VLKKILNSNT NKIEKELLQR NQKVIERRTS SSGRAIPKDL PTSKSPSPKP 180
  181 RTHSQSPSIS KHNSFSESIN SAKSNRSSRI FETFINAKEQ NSKKHAAPVP LTSKLVNGLP 240
  241 KRQVTVGLGL NTGTNFKNSS AKSKRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle