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Protein Overview: SIW14

General Information:
Name(s) found: SIW14 / YNL032W [SGD]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein amino acid dephosphorylation [ISSLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    response to stress [IGILink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLYQAKNDE GSDPKSSSKI DDLIENEAEI IRLIKEDGKL LIDNGDGRDI HNIIQEDKLL  60
   61 SVEFNEVLKR FHGEEKSDIP RKEFDEDEDD GYDSNEHHQK TIEVMNTLNH VINKEVIPPE 120
  121 NFSHVVGEIY RSSFPRQENF SFLHERLKLK SILVLIPEEY PQENLNFLKL TGIKLYQVGM 180
  181 SGNKEPFVNI PSHLLTKALE IVLNPANQPI LIHCNRGKHR TGCLIGCIRK LQNWSLTMIF 240
  241 DEYRRFAFPK ARALDQQFIE MYDDDEIKRI ASKNNWLPLQ W

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OCA1 OCA2 OCA4 OCA5 SIW14
    View Details Krogan NJ, et al. (2006) OCA1 OCA2 SIW14
    View Details Gavin AC, et al. (2006) OCA1 OCA4 OCA5 SIW14
    View Details Ho Y, et al. (2002) EMI2 HXT6 OCA1 SIW14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIW14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] deduced N/A No confident structure predictions are available.
    2 View Details [85..179]
    [197..218]    		 PSI-BLAST 31.69897 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
    3 View Details [180..196]
    [219..281]    		 PSI-BLAST 31.69897 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  6.6585143972081 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.44546424348532 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.56007278295923 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.95004535887255 bayes_pls_golite062009
  • hydrolase activity
    		•  1.5596484415033 bayes_pls_golite062009
  • protein binding
    		•  1.28180613509993 bayes_pls_golite062009
  • binding
    		•  1.27238793273026 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.05085928819585 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.541577955624444 bayes_pls_golite062009
  • actin binding
    		•  0.174917691236515 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0776644624761281 bayes_pls_golite062009
  • kinase activity
    		•  0.0715870881653981 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle