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Protein Overview: OCA1

General Information:
Name(s) found: OCA1 / YNL099C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKVGEYED VPEDESRLTE ENVSVPEEEV EDEDEEEDDD DDHIYINEET ESGREKVLVS  60
   61 HAPQERIVPP LNFCPVERYL YRSGQPSPVN FPFLLNLKLK TIIWLSNEEP QDTLLEFCDT 120
  121 HRINLQFAAI NPDAGEDDNP WDGLTEHSII NVLQTIVTQE NYPLLVCCGM GRHRTGTVIG 180
  181 CLRRIMGWNL ASVSEEYRRF TGSRGGRILV ELLIEAFDTN LVKIDKNKAP SWLLTALE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OCA1 OCA2 OCA4 OCA5 SIW14
    View Details Krogan NJ, et al. (2006) OCA1 OCA2 SIW14
    View Details Gavin AC, et al. (2006) OCA1 OCA4 OCA5 SIW14
    View Details Ho Y, et al. (2002) OCA1 OCA2 SIW14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OCA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 35.69897 VH1-related dual-specificity phosphatase, VHR

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  6.6585143972081 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.44546424348532 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.56007278295923 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • hydrolase activity
    		•  4.08088661270715 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.95004535887255 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.05085928819585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.778925490811536 bayes_pls_golite062009
  • DNA binding
    		•  0.744259483210066 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0776644624761281 bayes_pls_golite062009
  • kinase activity
    		•  0.0715870881653981 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle