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Protein Overview: PRP28

General Information:
Name(s) found: PRP28 / YDR243C [SGD]
Description(s) found:
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  • gi|817829|emb|CAA89729.1| Prp28p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|666103|emb|CAA40255.1| pre-mRNA splicing factor RNA helicase PRP28 (helicase CA8) [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6320449|ref|NP_010529.1| RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site; Prp28p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1172596|sp|P23394.2|PRP28_YEAST RecName: Full=Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; AltName: Full=Helicase CA8 [NCBI NR]
  • pir||A39624 probable helicase (EC 3.6.1.-) PRP28 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 OS=Saccharomyces cerevisiae GN=PRP28 PE=1 SV=2 [Swiss-Prot]
  • (P23394) Pre-mRNA splicing factor RNA helicase PRP28 (Helicase CA8) [Swiss-Prot]
  • PRP28 Pre-mRNA splicing factor RNA helicase of DEAD box family [mips]
  • RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site [SGD]
  • PRP28, Chr IV from 948509-950275, reverse complement [yeast_orfs2]
  • Chr IV from 948509-950275, reverse complement [yeastorf3.fasta]
  • Chr IV from 950275-948509, reverse complement [yeastorf5.fasta]
  • PRP28 SGDID:S0002651, Chr IV from 950276-948510, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PRP28 SGDID:S0002651, Chr IV from 950278-948512, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Prp28p [Saccharomyces cerevisiae]gi|817829|emb|CAA89729.1| Prp28p [Saccharomyces cerevisiae]gi|666103|emb|CAA40255.1| pre-mRNA splicing factor RNA helicase PRP28 (helicase CA8) [Saccharomyces cerevisiae]gi|1172596|sp|P23394|PR28_YEAST Pre-mRNA splicing [nrdb_11152004_Chlamydomonas]
  • PRP28 SGDID:S000002651, Chr IV from 950278-948512, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PRP28 SGDID:S000002651, Chr IV from 950280-948514, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" [yeast-contam.fasta]
  • PRP28 SGDID:S000002651, Chr IV from 950281-948515, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 (Helicase CA8) [nr-271106-contam.fasta]
  • Prp28p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • pre-mRNA splicing factor RNA helicase PRP28 (helicase CA8) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site; Prp28p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP28 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PRP28 SGDID:S000002651, Chr IV from 950284-948518, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" [yeast-030211-contam.fasta]
  • PRP28 SGDID:S000002651, Chr IV from 950284-948518, Genome Release 64-2-1, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family; involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site" [20141208_orf_trans.fasta]
  • YDR243C SGDID:S000002651, Chr IV from 950284-948518, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: U5 snRNP [IPILink to PubMed article]
    spliceosomal complex [TASLink to PubMed article]
    Biological Process: RNA splicing [IEA]
    mRNA processing [IEA]
    cis assembly of pre-catalytic spliceosome [TAS]
    Molecular Function: ATP-dependent RNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARPIDVSQL IAGINKKKGL DENTSGKISK PRFLNKQERS KQERLKENEE SLTPTQSDSA  60
   61 KVEIKKVNSR DDSFFNETND KKRNPSKQNG SKFHFSWNES EDTLSGYDPI VSTRAIDLLW 120
  121 KGKTPKNAAE SSYMGKHWTE KSLHEMNERD WRILKEDYAI VTKGGTVENP LRNWEELNII 180
  181 PRDLLRVIIQ ELRFPSPTPI QRITIPNVCN MKQYRDFLGV ASTGSGKTLA FVIPILIKMS 240
  241 RSPPRPPSLK IIDGPKALIL APTRELVQQI QKETQKVTKI WSKESNYDCK VISIVGGHSL 300
  301 EEISFSLSEG CDILVATPGR LIDSLENHLL VMKQVETLVL DEADKMIDLG FEDQVTNILT 360
  361 KVDINADSAV NRQTLMFTAT MTPVIEKIAA GYMQKPVYAT IGVETGSEPL IQQVVEYADN 420
  421 DEDKFKKLKP IVAKYDPPII IFINYKQTAD WLAEKFQKET NMKVTILHGS KSQEQREHSL 480
  481 QLFRTNKVQI MIATNVAARG LDIPNVSLVV NFQISKKMDD YIHRIGRTGR AANEGTAVSF 540
  541 VSAAEDESLI RELYKYVRKH DPLNSNIFSE AVKNKYNVGK QLSNEIIY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HSH155 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TOS4 UTP21 YML6
    View Details Ho Y, et al. (2002) ARO1 ARP2 CAT5 CPA1 IME4 PRB1 PRP28 RNQ1 SWM1 TCB3 URA7
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CDC5 CEF1 CLF1 CUS1 CUS2 CWC2 CWC21 CWC22 CWC23 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP28 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] deduced N/A No confident structure predictions are available.
    2 View Details [140..402] PSI-BLAST 503.0 Putative DEAD box RNA helicase
    3 View Details [403..588] PSI-BLAST 503.0 Putative DEAD box RNA helicase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle