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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Apg12. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 38 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC1
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial transport
  • aerobic respiration
  • ATP:ADP antiporter activity
  • AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • ADE5,7
  • cytoplasm
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • purine base metabolic process
  • phosphoribosylamine-glycine ligase activity
  • phosphoribosylformylglycinamidine cyclo-ligase activity
  • AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ARC1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • tRNA aminoacylation for protein translation
  • tRNA export from nucleus
  • tRNA binding
  • ARO1
  • cytoplasm
  • aromatic amino acid family biosynthetic process
  • shikimate kinase activity
  • 3-dehydroquinate dehydratase activity
  • 3-phosphoshikimate 1-carboxyvinyltransferase activity
  • 3-dehydroquinate synthase activity
  • shikimate 5-dehydrogenase activity
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • ATG11
  • extrinsic to membrane
  • peroxisome degradation
  • telomere maintenance
  • protein targeting to vacuole
  • molecular_function
  • ATG12
  • membrane fraction
  • autophagy
  • protein targeting to vacuole
  • protein tag
  • ATG17
  • cytoplasm
  • autophagy
  • telomere maintenance
  • kinase activator activity
  • CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • CPA2
  • carbamoyl-phosphate synthase complex
  • arginine biosynthetic process
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • FET4
  • integral to plasma membrane
  • plasma membrane
  • low-affinity iron ion transport
  • intracellular copper ion transport
  • copper ion import
  • iron ion transmembrane transporter activity
  • copper ion transmembrane transporter activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GFA1
  • cellular_component
  • cell wall chitin biosynthetic process
  • glutamine-fructose-6-phosphate transaminase (isomerizing) activity
  • GUS1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • glutamyl-tRNA aminoacylation
  • glutamate-tRNA ligase activity
  • IPP1
  • cytosol
  • phosphate metabolic process
  • inorganic diphosphatase activity
  • PPX1
  • cytoplasm
  • mitochondrial matrix
  • cytosol
  • plasma membrane
  • polyphosphate metabolic process
  • exopolyphosphatase activity
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • PTC7
  • mitochondrion
  • biological_process
  • REP1
  • nucleus
  • 2-micrometer plasmid partitioning
  • molecular_function
  • REX2
  • mitochondrion
  • RNA processing
  • 3'-5' exonuclease activity
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEC18
  • cytoplasm
  • extrinsic to plasma membrane
  • vacuole inheritance
  • ER to Golgi vesicle-mediated transport
  • vacuole fusion, non-autophagic
  • ATPase activity
  • TCB1
  • mitochondrion
  • biological_process
  • lipid binding
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TYR1
  • cytoplasm
  • tyrosine metabolic process
  • prephenate dehydrogenase activity
  • YHR020W
  • ribosome
  • tRNA aminoacylation for protein translation
  • proline-tRNA ligase activity
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • YNL208W
  • mitochondrion
  • ribosome
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle 3.7088E-13 38 23 8 6292
    proteasome accessory complex 3.7088E-13 38 23 8 6292
    proteasome complex 2.5658E-10 38 48 8 6292
    proteasome regulatory particle, lid subcomplex 1.5082E-9 38 10 5 6292
    proteasome regulatory particle, base subcomplex 1.6654E-5 38 9 3 6292
    methionyl glutamyl tRNA synthetase complex 2.115E-4 38 4 2 6292
    protein complex 4.7044E-3 38 1137 14 6292
    plasma membrane enriched fraction 6.0394E-3 38 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular catabolic process 4.3961E-7 38 415 13 6292
    cellular protein catabolic process 5.424E-7 38 171 9 6292
    protein catabolic process 1.263E-6 38 189 9 6292
    modification-dependent protein catabolic process 3.1018E-6 38 156 8 6292
    ubiquitin-dependent protein catabolic process 3.1018E-6 38 156 8 6292
    catabolic process 3.3518E-6 38 496 13 6292
    proteolysis involved in cellular protein catabolic process 3.5786E-6 38 159 8 6292
    modification-dependent macromolecule catabolic process 4.5116E-6 38 164 8 6292
    proteolysis 1.2406E-5 38 188 8 6292
    cellular macromolecule catabolic process 2.025E-5 38 265 9 6292
    macromolecule catabolic process 4.6178E-5 38 294 9 6292
    amine metabolic process 7.8854E-5 38 243 8 6292
    cellular metabolic process 9.7975E-5 38 3033 30 6292
    cellular amino acid metabolic process 1.5618E-4 38 199 7 6292
    cellular protein metabolic process 2.4145E-4 38 1074 16 6292
    metabolic process 2.4595E-4 38 3157 30 6292
    cellular amine metabolic process 3.0704E-4 38 222 7 6292
    protein metabolic process 4.6916E-4 38 1136 16 6292
    cellular amino acid and derivative metabolic process 5.3158E-4 38 243 7 6292
    tRNA aminoacylation for protein translation 9.7866E-4 38 33 3 6292
    tRNA aminoacylation 9.7866E-4 38 33 3 6292
    amino acid activation 9.7866E-4 38 33 3 6292
    autophagy 1.9835E-3 38 42 3 6292
    organic acid metabolic process 3.3247E-3 38 333 7 6292
    oxoacid metabolic process 3.3247E-3 38 333 7 6292
    carboxylic acid metabolic process 3.3247E-3 38 333 7 6292
    arginine metabolic process 4.0408E-3 38 16 2 6292
    cellular ketone metabolic process 4.1145E-3 38 346 7 6292
    cellular process 4.7634E-3 38 4426 34 6292
    low-affinity iron ion transport 6.0394E-3 38 1 1 6292
    tyrosine metabolic process 6.0394E-3 38 1 1 6292
    aromatic amino acid family metabolic process 9.0157E-3 38 24 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.5607E-5 38 54 5 6292
    ATP:ADP antiporter activity 1.0615E-4 38 3 2 6292
    peptidase activity, acting on L-amino acid peptides 2.3888E-4 38 95 5 6292
    solute:solute antiporter activity 9.7204E-4 38 8 2 6292
    antiporter activity 1.245E-3 38 9 2 6292
    transferase activity, transferring nitrogenous groups 5.113E-3 38 18 2 6292
    transaminase activity 5.113E-3 38 18 2 6292
    peptidase activity 5.5603E-3 38 192 5 6292
    3-dehydroquinate dehydratase activity 6.0394E-3 38 1 1 6292
    3-dehydroquinate synthase activity 6.0394E-3 38 1 1 6292
    exopolyphosphatase activity 6.0394E-3 38 1 1 6292
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity 6.0394E-3 38 1 1 6292
    phosphoribosylformylglycinamidine cyclo-ligase activity 6.0394E-3 38 1 1 6292
    shikimate 5-dehydrogenase activity 6.0394E-3 38 1 1 6292
    phosphoribosylamine-glycine ligase activity 6.0394E-3 38 1 1 6292
    prephenate dehydrogenase activity 6.0394E-3 38 1 1 6292
    shikimate kinase activity 6.0394E-3 38 1 1 6292
    ornithine-oxo-acid transaminase activity 6.0394E-3 38 1 1 6292
    3-phosphoshikimate 1-carboxyvinyltransferase activity 6.0394E-3 38 1 1 6292
    ATP binding 9.0157E-3 38 24 2 6292
    adenyl ribonucleotide binding 9.7626E-3 38 25 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle