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Protein Overview: TIF35

General Information:
Name(s) found: TIF35 / YDR429C [SGD]
Description(s) found:
Found 30 descriptions.
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  • eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 274 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 3 complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: translational initiation [IDALink to PubMed article]
    Molecular Function: translation initiation factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVAPEEII ENADGSRSII TYKIEDGVKY KITQKVKEVK VLEKVHKSVA ERKNWHKYGS  60
   61 EKGSPAGPSA VTARLGEEVE LRLSRNWKQA EEERIQKEKA SLTKTGLQCR LCGNDHMTMN 120
  121 CPFKTILSEL SALEDPATNE GGVEAASEEK AGQVGGAGSI PGQYVPPSRR AGARDPSSDA 180
  181 YRDSRERDDM CTLKIMQVNE NADENSLREE LLFPFAPIPR VSVVRNKETG KSRGLAFVTF 240
  241 SSEEVAEQAL RFLDGRGYMN LILRVEWSKP KVKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 GCD11 HCR1 NIP1 PRT1 RPG1 SUI1 TIF34 TIF35 TIF5
    View Details (MIPS) Mewes HW, et al. (2004) GCD10 NIP1 PRT1 RPG1 SUI1 TIF34 TIF35
    View Details Krogan NJ, et al. (2006) ADE8 CHZ1 ECM2 HCR1 HEM12 KAP122 NIP1 PRT1 RPG1 SUI1 SYH1 TIF34 TIF35 TIF5 YOR052C
    View Details Gavin AC, et al. (2006) FUN12 HCR1 NIP1 PRT1 RLI1 RPG1 TIF34 TIF35 TIF5
    View Details Gavin AC, et al. (2002) ASC1 ATG9 CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 CLU1 FUN12 GLT1 HCR1 HHF1, HHF2 HOT1 IST2 ISW1 ISW2 KTR5 LSG1 NIP1 NOG1 NOP7 PRT1 RET1 RIC1 RLI1 RPG1 RVB2 SPT16 SPT5 SSA4 SUA7 SUI1 SUI2 SUI3 SUP45 TIF34 TIF35 TIF5 UTP22 UTP6 VPS1 YGL036W YTA7
    View Details Ho Y, et al. (2002) ARG4 ATP3 AYR1 BEM2 COP1 COR1 CPR6 DUF1 EDE1 ERG27 FOL2 GPT2 HTB2 LHS1 LIA1 MAE1 NIP1 OM45 PCT1 PDA1 PET10 PET9 PIL1 POR1 PRE10 PRO3 RET2 RNR2 RPG1 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 SES1 SRV2 SUI1 TIF34 TIF35 TPA1 UBI4 YNL181W
    View Details Qiu et al. (2008) CLU1 FUN12 GCD11 HCR1 NIP1 PRT1 RPG1 RPL4B SUI1 SUI2 SUI3 TIF34 TIF35 TIF5 YGR054W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CCE1 TIF35 1 Unpublished Fields Lab Data
    View Screen CTF13 TIF35 1 Unpublished Fields Lab Data
    View Screen RAS2 TIF35 1 Unpublished Fields Lab Data
    View Screen TOM22 TIF35 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TIF35 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [65..183] PSI-BLAST 78.0 Sex-lethal protein
    3 View Details [184..274] PSI-BLAST 78.0 Sex-lethal protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mRNA binding
    		•  4.52007814408702 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51665560478175 bayes_pls_golite062009
  • RNA binding
    		•  4.50438526063124 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • translation initiation factor activity
    		•  3.27900316559423 bayes_pls_golite062009
  • structural molecule activity
    		•  2.78501986457503 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.7776932219095 bayes_pls_golite062009
  • DNA binding
    		•  1.65208390030564 bayes_pls_golite062009
    		• 1.49431666307335 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.90573796517364 bayes_pls_golite062009
  • RNA cap binding
    		•  0.847034036194541 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • transcription factor activity
    		•  0.795084003256395 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.32812362201346 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.304235325881492 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle