Protein Overview: BDF2

General Information:
Name(s) found:	BDF2 / YDL070W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74583636\|sp\|Q07442.1\|BDF2_YEAST RecName: Full=Bromodomain-containing factor 2 [NCBI NR] gi\|6320132\|ref\|NP_010213.1\| Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with [NCBI NR] pir\|\|S67605 hypothetical protein YDL070w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1431082\|emb\|CAA98636.1\| BDF2 [Saccharomyces cerevisiae] [NCBI NR] Bromodomain-containing factor 2 OS=Saccharomyces cerevisiae GN=BDF2 PE=1 SV=1 [Swiss-Prot] BDF2 Bromodomain protein involved in transcription initiation at TATA-containing promoters [mips] Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p [SGD] BDF2, Chr IV from 331024-332940 [yeast_orfs2] Chr IV from 331024-332940 [yeastorf3.fasta] >Q07442 (Q07442) ORF YDL070W [4932.FASTACCERV.txt] BDF2 SGDID:S0002228, Chr IV from 331025-332941, Verified ORF [yeastflysequest.fasta] Bdf2p [Saccharomyces cerevisiae]gi\|1431082\|emb\|CAA98636.1\| BDF2 [Saccharomyces cerevisiae]gi\|2131324\|pir\|\|S67605 hypothetical protein YDL070w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] (Q07442) BDF2 protein [cerv4932.FASTAC] BDF2 SGDID:S000002228, Chr IV from 331025-332941, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal regi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Bromodomain-containing factor 2 [nr-271106-contam.fasta] Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; Bdf2p [Saccharomyces [nr-271106-contam.fasta] BDF2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] BDF2 SGDID:S000002228, Chr IV from 331025-332941, Uncharacterized ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-termin [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] BDF2 SGDID:S000002228, Chr IV from 331025-332941, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] BDF2 SGDID:S000002228, Chr IV from 331025-332941, Uncharacterized ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p" [SGDyeast.20101221.fasta] Bromodomain-containing factor 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BDF2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] BDF2 SGDID:S000002228, Chr IV from 331024-332940, Genome Release 64-1-1, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p" [yeast-030211-contam.fasta] BDF2 SGDID:S000002228, Chr IV from 331024-332940, Genome Release 64-2-1, Verified ORF, "Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YDL070W SGDID:S000002228, Chr IV from 331024-332940, Genome Release 64-1-1, Verified ORF, "Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	638 amino acids
Gene Ontology:
Cellular Component:	nucleus [TAS]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRTNMDTRH AHSALLAAPQ SATANSRSSN SSSESSSNKN NINVGVGDDS GNVSAVSIDD  60
   61 GPHFRDIFHY GHEENYKLAS SGITNLNSSS HAHQTLSPIS ISNASTPESF PEHPLGLERE 120
  121 TEPALEAEME AEELPPHQSK YLLSSIKATK RLKDARPFLK PVDPIALNIP HYFNYVQTPM 180
  181 DLSLIETKLQ GNVYHSVEQV TSDFKTMVDN CLNFNGPESS ISSMAKRIQK YFEKKLSAMP 240
  241 PRVLPASALK KTSRNRKKNE DMDSPLVIRR SVSTTNDNIG ESGNREGVSG GRPKRTIHPP 300
  301 KSKDLFDIYE NSKPKSKTLQ KKFRTCLKIL KVLMSKKNSD INFPFLQPVD PIALNLPNYF 360
  361 DVVKNPMDLG TISNNLMNWK YKTIDQFVDD LNLVFYNCFQ FNPEGNEVHS MGKKLKELFN 420
  421 FHWLENQDIL NEIETDSDLE EDNYSSSYSS DDEYDDEDIN ENDITNPAIQ YLEQKLKKME 480
  481 VELQQLKRQE LSKLSKERKR KHLGKTLLRR KAMKHSVDDL KKSITDKINE LSDLEMNGMI 540
  541 RIIKNSLPAD EILTSNEDEI EIDLDILDEA TIARIYERYF EKKNNNNSKR KLSGNYSTAP 600
  601 TNKKKKTLKF LEKDEIINNN NYSDSEEDSS DSSDSDSD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		BDF1 BDF2
View Details	Gavin AC, et al. (2002)		BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BIR1	sample bir 1 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GLC7	BDF2	2	Uetz P, et al. (2000)
View Screen	IMP4	BDF2	2	Unpublished Fields Lab Data
View Screen	KAP104	BDF2	1	Unpublished Fields Lab Data
View Screen	PRP42	BDF2	1	Unpublished Fields Lab Data
View Screen	ADH2	BDF2	1	Unpublished Fields Lab Data
View Screen	SMC5	BDF2	1	Hazbun TR, et al. (2003)
View Screen	COG4	BDF2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	BDF2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..121]	deduced	N/A	No confident structure predictions are available.
2	View Details	[122..242]	Pfam	29.552842	Bromodomain No confident structure predictions are available.
3	View Details	[243..315]	deduced	N/A	Confident ab initio structure predictions are available.
4	View Details	[316..445]	PSI-BLAST	131.533179	GCN5
5	View Details	[446..502]	deduced	N/A	Confident ab initio structure predictions are available.
6	View Details	[503..638]	MSA	5.053991	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2