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Protein Overview: RGC1

General Information:
Name(s) found: RGC1 / YPR115W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1083 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDYFTFPKQ ENGGISKQPA TPGSTRSSSR NLELPKNYRS FGGSSDELAS MYSADSQYLM  60
   61 DMIPDSLTLK NEPASGNTQM NGPDGKENKD IKLDEYILPK TDPRSPYYIN MPIPKKLPKS 120
  121 EGKARAKQKV NRADPSDLDV ENIYETSGEF VREYPTDILI DRFHKWKKIL KSLIAYFREA 180
  181 AYSQEQIARI NYQMKNAVKF AFLTDLEDET NKLVDPSISK LPTKKPQPVP LAAQKLDSKY 240
  241 DTDVEQPQSI QSVPSEEVAS ASSGFMKFGS GSIQDIQVIL KKYHLSLGSQ QYKISKEILA 300
  301 YIIPKLTDLR KDLTTKMKEI KELNGDFKTN IGEHIKITSR LLNKYIASVK LLDEASTSGD 360
  361 KQGEKLKPKH DPYLLKLQLD LQLKRQLLEE NYLREAFLNL QSAALQLEKI VYSKIQSALQ 420
  421 RYSALIDSEA RLMIKNLCHE LQQGILSRPP AVEWDNFVSH HPTCLMNLKS TDPPPQPRRL 480
  481 SDIVYPNMKS PLAKCIRVGY LLKKTESSKS FTKGYFVLTT NYLHEFKSSD FFLDSKSPRS 540
  541 KNKPVVEQSD ISRVNKDGTN AGSHPSSKGT QDPKLTKRRK GLSSSNLYPI SSLSLNDCSL 600
  601 KDSTDSTFVL QGYASYHSPE DTCTKESSTT SDLACPTKTL ASNKGKHQRT PSALSMVSVP 660
  661 KFLKSSSVPK EQKKAKEEAN INKKSICEKR VEWTFKIFSA SLEPTPEESK NFKKWVQDIK 720
  721 ALTSFNSTQE RSNFIEEKIL KSRNHNNGKS SQRSKNSTYI TPVDSFVNLS EKVTPSSSVT 780
  781 TLNTRKRANR PRYIDIPKSA NMNAGAMNSV YRSKVNTPAI DENGNLAIVG ETKNSAPQNG 840
  841 MSYTIRTPCK SPYSPYTGEG MLYNRSADNL MASSSRKASA PGEVPQIAVS NHGDEAIIPA 900
  901 SAYSDSSHKS SRASSVASIH NQRVDFYPSP LMNLPGVSPS CLALDGNANG YFGIPLNCNS 960
  961 EARRGSDLSP FEMESPLFEE NRTQNCSGSR KSSACHIPHQ CGPRKEGNDS RLIYGNEKGA1020
 1021 SQSRLTLKEP LTSKGVEAPY SSLKKTYSAE NVPLTSTVSN DKSLHSRKEG STNTVPATSA1080
 1081 SSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Gavin AC, et al. (2002) ACE2 ALT2 BCK1 CDC11 DRE2 ECM30 ENP2 IML1 MNL1 MTR4 MYO2 RGC1 SEC3 UBP15 YBL044W YJR098C YNL313C
    View Details Ho Y, et al. (2002) ARP7 DIG1 DIG2 FET4 GFA1 GUS1 HAS1 HXT6 KSS1 MKT1 MSE1 NAP1 PHO84 PIM1 PMA1 PYC1 RGC1 RPA135 RPN10 SEN1 STE12 STE7 TEC1 UBI4 YDR239C YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HUL5 RGC1 1 Unpublished Fields Lab Data
    View Screen SDO1 RGC1 1 Hazbun TR, et al. (2003)
    View Screen EST1 RGC1 1 Unpublished Fields Lab Data
    View Screen SPP382 RGC1 1 Hazbun TR, et al. (2003)
    View Screen APC5 RGC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RGC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..475] deduced N/A No confident structure predictions are available.
    2 View Details [476..747] Pfam 6.958607 PH domain No confident structure predictions are available.
    3 View Details [748..1083] deduced N/A No confident structure predictions are available.
    4 View Details [469..805] FFAS03 0.982 Insulin receptor substrate 1, IRS-1
    5 View Details [806..966] deduced N/A No confident structure predictions are available.
    6 View Details [967..1083] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.92972815841164 bayes_pls_golite062009
  • protein binding
    		•  1.26119545864643 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0325416327974032 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle