Protein Overview: INP2

General Information:
Name(s) found:	INP2 / YMR163C [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene [SGD]
Organism:	Saccharomyces cerevisiae
Length:	705 amino acids
Gene Ontology:
Cellular Component:	peroxisome [IDA] integral to peroxisomal membrane [IDA] cytoplasm [IDA]
Biological Process:	peroxisome inheritance [IEP][IGI][IMP][IPI]
Molecular Function:	protein anchor [IEP][IMP][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ EFYSTWRKPS  60
   61 LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI ISRIFMQQPF GVTHQFFEEF 120
  121 RYSIITSHFL NDMNHYRLSL HLDQSIMNFH KSSTLLKNVP PKSVPFMATK YGKLAVAEDK 180
  181 KLYFRQNFNY LSMIITSYRV LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL 240
  241 ICYKTLLKVR KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV 300
  301 FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD LDGKLYRLKL 360
  361 LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV QLKKKYNPIG TFQNIVSLLR 420
  421 GLHSLLSTVL VSLNDHKQIL YAFPEETSTN TGCERANVCS FSKNDKLFQA LNYLKMIENN 480
  481 LLAIDIRNGI TENDRNIIED KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK 540
  541 GRKSPRSSSV QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV 600
  601 DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE LLRKAQASMS 660
  661 VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL LGNDS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
View Details	Qiu et al. (2008)		INP1 INP2 PEX13 PEX17 PEX28 PEX29 PEX30 PEX31 PEX7

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HMT1	INP2	1	Unpublished Fields Lab Data
View Screen	SDP1	INP2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	INP2	Huh WK, et al. (2003)
View Data	INP2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..160]	deduced	N/A	No confident structure predictions are available.
2	View Details	[161..447]	ORFEUS	7.29	Hemolysin E (HlyE, ClyA, SheA)
3	View Details	[448..705]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.73

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2