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Protein Overview: PRP39

General Information:
Name(s) found: PRP39 / YML046W [SGD]
Description(s) found:
Found 23 descriptions.
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  • U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: commitment complex [IGILink to PubMed article]
    U1 snRNP [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA 5'-splice site recognition [IGILink to PubMed article]
    Molecular Function: pre-mRNA 5'-splice site binding [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDETNFTIE DIEPRPDALR GLDTQFLQDN TALVQAYRGL DWSDISSLTQ MVDVIEQTVV  60
   61 KYGNPNDSIK LALETILWQI LRKYPLLFGF WKRFATIEYQ LFGLKKSIAV LATSVKWFPT 120
  121 SLELWCDYLN VLCVNNPNET DFIRNNFEIA KDLIGKQFLS HPFWDKFIEF EVGQKNWHNV 180
  181 QRIYEYIIEV PLHQYARFFT SYKKFLNEKN LKTTRNIDIV LRKTQTTVNE IWQFESKIKQ 240
  241 PFFNLGQVLN DDLENWSRYL KFVTDPSKSL DKEFVMSVFD RCLIPCLYHE NTWMMYIKWL 300
  301 TKKNISDEVV VDIYQKANTF LPLDFKTLRY DFLRFLKRKY RSNNTLFNNI FNETVSRYLK 360
  361 IWPNDILLMT EYLCMLKRHS FKNSLDQSPK EILEKQTSFT KILETSITNY INNQIDAKVH 420
  421 LQTLINDKNL SIVVVELIKT TWLVLKNNMQ TRKYFNLYQK NILIKNSVPF WLTYYKFEKS 480
  481 NVNFTKLNKF IRELGVEIYL PTTVMNDILT DYKTFYLTHS NIVTYESSII DSNTFDPILY 540
  541 PELKMSNPKY DPVLNTTANV DWHKKTEWKE AGHIGITTER PQISNSIIEC NSGTLIQKPI 600
  601 SLPNFRNLEK INQVKINDLY TEEFLKEGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CBC2 DIB1 HSH155 LEA1 LUC7 MUD1 NAM8 PRP31 PRP39 PRP4 PRP40 PRP42 PRP6 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SMX3 SNP1 SNU114 SNU56 SNU71 STO1 YHC1
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2006) LUC7 MUD1 NAM8 PRP39 PRP40 PRP42 SNP1 SNU56 SNU71 YHC1
    View Details Gavin AC, et al. (2002) AAR2 AIR2 BRR1 BUD31 BUR2 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 KAP95 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSH4 MSL1 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SCP160 SEN1 SGV1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 SRO9 SRP1 STO1 SYF1 THO2 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6 YRA2
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CDC5 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM7 LSM8 LUC7 MAK5 MSL1 MSL5 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RRN10 PRP39 1 Unpublished Fields Lab Data
    View Screen RAD6 PRP39 1 Unpublished Fields Lab Data
    View Screen COF1 PRP39 1 Unpublished Fields Lab Data
    View Screen UBC7 PRP39 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP39 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..209] PSI-BLAST 18.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [210..270] PSI-BLAST 18.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [271..353] PSI-BLAST 18.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [354..411] PSI-BLAST 7.0 Cyclophilin 40; Cyclophilin 40 isomerase domain
    6 View Details [412..546] PSI-BLAST 7.0 Cyclophilin 40; Cyclophilin 40 isomerase domain
    7 View Details [547..629] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  2.76684454218635 bayes_pls_golite062009
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.96129657517284 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62783430593918 bayes_pls_golite062009
  • DNA binding
    		•  1.62663906748938 bayes_pls_golite062009
  • transcription factor activity
    		•  0.934706586922936 bayes_pls_golite062009
  • signal sequence binding
    		•  0.8574224889202 bayes_pls_golite062009
  • transcription factor binding
    		•  0.441518464573089 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.19094857768269 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle