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Protein Overview: RGR1

General Information:
Name(s) found: RGR1 / YLR071C [SGD]
Description(s) found:
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  • gi|6323100|ref|NP_013172.1| Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation; Rgr1p [Sacch [NCBI NR]
  • gi|51013335|gb|AAT92961.1| YLR071C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|31077171|sp|P19263.2|MED14_YEAST RecName: Full=Mediator of RNA polymerase II transcription subunit 14; AltName: Full=Mediator complex subunit 14; AltName: Full=Glucose repression regulatory protein 1 [NCBI NR]
  • gi|2133085|pir||S64903 regulatory protein RGR1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1360426|emb|CAA97628.1| RGR1 [Saccharomyces cerevisiae] [NCBI NR]
  • (P19263) Mediator complex subunit RGR1 (Glucose repression regulatory protein) [Swiss-Prot]
  • Mediator of RNA polymerase II transcription subunit 14 OS=Saccharomyces cerevisiae GN=RGR1 PE=1 SV=2 [Swiss-Prot]
  • RGR1 DNA-directed RNA polymerase II holoenzyme subunit [mips]
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation [SGD]
  • RGR1, Chr XII from 275379-278627, reverse complement [yeast_orfs2]
  • Chr XII from 275379-278627, reverse complement [yeastorf3.fasta]
  • Chr XII from 278627-275379, reverse complement [yeastorf5.fasta]
  • RGR1 SGDID:S0004061, Chr XII from 278627-275379, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, HO repression, RME1 repression and sporulation [Saccharomyces cerevisiae]gi|51013335 [nrdb_11152004_Chlamydomonas]
  • RGR1 SGDID:S000004061, Chr XII from 278627-275379, reverse complement, Verified ORF, "Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RGR1 SGDID:S000004061, Chr XII from 278627-275379, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • YLR071C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, HO repression, RME1 repression and sporulation; Rgr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RNA polymerase II mediator complex subunit 14 (Glucose repression regulatory protein 1) [nr-271106-contam.fasta]
  • RGR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • regulatory protein RGR1 - yeast (Saccharomyces cerevisiae) [nr-271106-contam.fasta]
  • RGR1 SGDID:S000004061, Chr XII from 278627-275379, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" [yeast-bovrabprots.fasta]
  • RGR1 SGDID:S000004061, Chr XII from 278627-275379, reverse complement, Verified ORF, "Component of RNA polymerase II holoenzyme/mediator complex; affects chromatin structure and transcriptional regulation of diverse genes; required for glucose repression, HO repression, RME1 repression and sporulation" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Mediator of RNA polymerase II transcription subunit 14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGR1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RGR1 SGDID:S000004061, Chr XII from 278626-275378, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" [yeast-030211-contam.fasta]
  • RGR1 SGDID:S000004061, Chr XII from 278626-275378, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" [20141208_orf_trans.fasta]
  • YLR071C SGDID:S000004061, Chr XII from 278626-275378, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1082 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    mediator complex [IDA][IEA]
    Biological Process: transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: RNA polymerase II transcription mediator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTIGSPQM LANEERLSNE MHALKNRSEQ NGQEQQGPVK NTQLHGPSAT DPETTATQKE  60
   61 SLEMVPKDTS AATMTSAPPP ALPHVEINQV SLALVIRNLT VFTMKELAQY MKTNVHTQAN 120
  121 EPNSAKKIRF LQLIIFLRTQ FLKLYVLVKW TRTIKQNNFH VLIDLLNWFR TTNMNVNNCI 180
  181 WALKSSLNSM TNAKLPNVDL VTALEVLSLG RPNLPTHNFK LSGVSNSMDM VDGMAKVPIG 240
  241 LILQRLKDLN LTVSIKIALM NIPKPLNSYH IKNGRIYFTV PNEFEIQLST VNRQSPLFFV 300
  301 DLKLLFNTEA EQTVSAVTEA TSTNGDSENN EENSSSNGNN LPLNKPRLEK LINEILLKSN 360
  361 DPLLSLYNFL HKYVLTLQLY MVHREFLKLA NGGKFSKSNL IHNYDSKKST ITVRYWLNGK 420
  421 MDSKGKITIG IQRTTESLIL KWDNQSASRA KNMPVIYNNI VSNIEGILDE IMFNHARIIR 480
  481 SELLARDIFQ EDEENSDVLL FQLPTTCVSM APIQLKIDLL SGQFYFRNPT PLLSNYASKI 540
  541 NRAEGPEELA RILQQLKLDK IIHVLTTMFE NTGWSCSRII KIDKPIRTQV NTGGESVVKK 600
  601 EDNKYAIAGN STTNSDVSLL LQRDLFIRLP HWPLNWYLIL SIISSKTSCV VEKRIGKIVS 660
  661 QRGKWNLKYL DNSNVMTVKL ESITYQKIMI LQRTILNRII NHMLIDSLNQ LEIRNKICSS 720
  721 EMINEQKLPQ YIIQGSNTND NISIITLELE SFLEGSKALN SILESSMFLR IDYSNSQIRL 780
  781 YAKFKRNTMM IQCQIDKLYI HFVQEEPLAF YLEESFTNLG IIVQYLTKFR QKLMQLVVLT 840
  841 DVVERLHKNF ESENFKIIAL QPNEISFKYL SNNDEDDKDC TIKISTNDDS IKNLTVQLSP 900
  901 SNPQHIIQPF LDNSKMDYHF IFSYLQFTSS LFKALKVILN ERGGKFHESG SQYSTMVNIG 960
  961 LHNLNEYQIV YYNPQAGTKI TICIELKTVL HNGRDKIQFH IHFADVAHIT TKSPAYPMMH1020
 1021 QVRNQVFMLD TKRLGTPESV KPANASHAIR LGNGVACDPS EIEPILMEIH NILKVDSNSS1080
 1081 SS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSE2 GAL11 MED1 MED11 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2 SSN3 YAP1
    View Details (MIPS) Mewes HW, et al. (2004) CSE2 DMC1 GAL11 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 TAF14
    View Details Krogan NJ, et al. (2006) CSE2 DSS1 GAL11 GPT2 IRC11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SIN4 SOH1 SRB2 SRB4 SRB5 SRB6 SRB7 SSN3 SSN8 THI72
    View Details Gavin AC, et al. (2006) CSE2 GAL11 MED1 MED11 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2
    View Details Gavin AC, et al. (2002) ADA2 ADH1 BLM10 CCT4 CDC6 COG3 CSE1 CSE2 DAM1 DBP9 DHH1 DUG1 ECM29 ENO2 EST3 FAB1 FBA1 FKS1 GAL11 GCN1 GCN20 GCN5 GFA1 IDH2 INO4 KAP123 KAP95 KTR3 LYS12 MDS3 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MIR1 MLH2 MLP1 MRPL6 NUD1 NUT1 NUT2 PDA1 PDB1 PGD1 PGK1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSE1 PUP3 RGR1 ROX3 RPG1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPO21 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRP12 SAM1 SCL1 SEC7 SIN4 SLC1 SLX9 SPA2 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SRV2 SSE2 SSN2 SSN3 SSN8 TAF6 TIF1, TIF2 UBP6 ULP1 YFL006W YHR020W YIL077C YMR310C YRA1
    View Details Ho Y, et al. (2002) RGR1 YMR1
    View Details Qiu et al. (2008) ADA2 CSE2 DMC1 GAL11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 ROX3 SGF29 SGF73 SIN4 SOH1 SRB2 SRB4 SRB5 SRB6 SRB7 TAF10 TAF12 TAF14 TAF3 TAF5 TAF6 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RIX1 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RGR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] deduced N/A No confident structure predictions are available.
    2 View Details [225..443] MSA 2.008975 View MSA. No confident structure predictions are available.
    3 View Details [444..1082] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle