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Protein Overview: YMR1

General Information:
Name(s) found: YMR1 / YJR110W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 688 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [IMPLink to PubMed article]
    inositol lipid-mediated signaling [IMPLink to PubMed article]
    phosphoinositide dephosphorylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: phosphatidylinositol-3-phosphatase activity [IDALink to PubMed article][IMPLink to PubMed article]
    phosphatase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI YGVHKNPGST  60
   61 LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK DYAVFSLDFG GDLHLQARKV 120
  121 YDSILNLTVL SNITQLYAFI YISNNLERKL PSPDSWDIYD PIKEFRRQGL DSKDETCPWR 180
  181 LSTVNEHYEF CPTYPSKLFV PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ 240
  241 PLPGLINQRS IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN 300
  301 YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD LNLPLEQNLI 360
  361 RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG WDRTSQVVSL LEICLDPFYR 420
  421 TFEGFMILVE KDWCSFGHRF LERSGHLNSD IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD 480
  481 DYAEDDEGGE DETNLINLSR ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL 540
  541 FEFNERFLRR LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI 600
  601 QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH KRDSVPISVD 660
  661 KKSKEHSNSD GGKGLNLSIF GFDMFNRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) RKM1 YMR1
    View Details Ho Y, et al. (2002) RGR1 YMR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YMR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] MSA 1.045972 View MSA. No confident structure predictions are available.
    2 View Details [171..688] MSA 5.05091 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphatase activity
    		•  7.03758345564381 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.82821455971597 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  6.3275802559101 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.83769298632658 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  4.98117543861822 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  4.03975183132282 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.71515178944974 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.71515178944974 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  2.60529675907066 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.5359729064152 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  2.05577133553311 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
    		•  1.72084618199574 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.68447406212301 bayes_pls_golite062009
  • hydrolase activity
    		•  1.64178855997223 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  1.51576958903553 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • kinase activity
    		•  0.541255358115631 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.532875179381704 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.502994448655937 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.359793029026564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • transferase activity
    		•  0.05073595579848 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle