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Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. Catalysis of the removal of one of the three phosphate groups of a phosphatidylinositol trisphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
Acc: GO:0016314
Aspect: Molecular Function
Desc: Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate.
Synonyms:
  • 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity
  • MMAC1
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016314 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle